Sadikot, R. T. & Blackwell, T. S. in Advanced Protocols in Oxidative Stress I Vol. 477 (ed. Armstrong, D.) 383–394 (Humana, 2008).
Syed, A. J. & Anderson, J. C. Applications of bioluminescence in biotechnology and beyond. Chem. Soc. Rev. 50, 5668–5705 (2021).
Sadikot, R. T. & Blackwell, T. S. Bioluminescence imaging. Proc. Am. Thorac. Soc. 2, 537–540 (2005).
Schramm, S. et al. Mechanically assisted bioluminescence with natural luciferase. Angew. Chem. Int. Ed. 59, 16485–16489 (2020).
Sacco, A., Doyonnas, R., Kraft, P., Vitorovic, S. & Blau, H. M. Self-renewal and expansion of single transplanted muscle stem cells. Nature 456, 502–506 (2008).
Jones, K. A. et al. Orthogonal luciferase–luciferin pairs for bioluminescence imaging. J. Am. Chem. Soc. 139, 2351–2358 (2017).
Alsawaftah, N., Farooq, A., Dhou, S. & Majdalawieh, A. F. Bioluminescence imaging applications in cancer: a comprehensive review. IEEE Rev. Biomed. Eng. 14, 307–326 (2020).
Yeh, H.-W. & Ai, H.-W. Development and applications of bioluminescent and chemiluminescent reporters and biosensors. Annu. Rev. Anal. Chem. 12, 129–150 (2019).
Prescher, J. A. & Contag, C. H. Guided by the light: visualizing biomolecular processes in living animals with bioluminescence. Curr. Opin. Chem. Biol. 14, 80–89 (2010).
Kumar, V. et al. Recent advances in fluorescent and colorimetric chemosensors for the detection of chemical warfare agents: a legacy of the 21st century. Chem. Soc. Rev. 52, 663–704 (2023).
Zhou, Y. & Yoon, J. Recent progress in fluorescent and colorimetric chemosensors for detection of amino acids. Chem. Soc. Rev. 41, 52–67 (2012).
Zhou, Y., Zhang, J. F. & Yoon, J. Fluorescence and colorimetric chemosensors for fluoride-ion detection. Chem. Rev. 114, 5511–5571 (2014).
Vega-Avila, E. & Pugsley, M. K. An overview of colorimetric assay methods used to assess survival or proliferation of mammalian cells. Proc. West. Pharmacol. Soc. 54, 10–14 (2011).
Lee, J.-S., Ulmann, P. A., Han, M. S. & Mirkin, C. A. A DNA-gold nanoparticle-based colorimetric competition assay for the detection of cysteine. Nano Lett. 8, 529–533 (2008).
Medley, C. D. et al. Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells. Anal. Chem. 80, 1067–1072 (2008).
Wen, S.-H. et al. Colorimetric assay conversion to highly sensitive electrochemical assay for bimodal detection of arsenate based on cobalt oxyhydroxide nanozyme via arsenate absorption. Anal. Chem. 91, 6487–6497 (2019).
Wignarajah, S. et al. Colorimetric assay for the detection of typical biomarkers for periodontitis using a magnetic nanoparticle biosensor. Anal. Chem. 87, 12161–12168 (2015).
Ravalin, M. et al. A single-component luminescent biosensor for the SARS-CoV-2 spike protein. J. Am. Chem. Soc. 144, 13663–13672 (2022).
Griss, R. et al. Bioluminescent sensor proteins for point-of-care therapeutic drug monitoring. Nat. Chem. Biol. 10, 598–603 (2014).
Ni, Y., Arts, R. & Merkx, M. Ratiometric bioluminescent sensor proteins based on intramolecular split luciferase complementation. ACS Sens. 4, 20–25 (2019).
van der Veer, H. J. et al. Glow-in-the-dark infectious disease diagnostics using CRISPR-Cas9-based split luciferase complementation. ACS Cent. Sci. 9, 657–667 (2023).
Yu, Q. et al. Semisynthetic sensor proteins enable metabolic assays at the point of care. Science 361, 1122–1126 (2018).
Ni, Y. et al. A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays. Nat. Commun. 12, 4586 (2021).
Yu, Q. et al. A biosensor for measuring NAD+ levels at the point of care. Nat. Metab. 1, 1219–1225 (2019).
Smirnova, D. V. & Ugarova, N. N. Firefly luciferase‐based fusion proteins and their applications in bioanalysis. Photochem. Photobiol. 93, 436–447 (2017).
Thor, D., Le Duc, D., Strotmann, R. & Schöneberg, T. Luciferase activity under direct ligand-dependent control of a muscarinic acetylcholine receptor. BMC Biotechnol. 9, 46 (2009).
Hall, M. P. et al. Toward a point-of-need bioluminescence-based immunoassay utilizing a complete shelf-stable reagent. Anal. Chem. 93, 5177–5184 (2021).
Elledge, S. K. et al. Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Nat. Biotechnol. 39, 928–935 (2021).
Xue, L., Yu, Q., Griss, R., Schena, A. & Johnsson, K. Bioluminescent antibodies for point-of-care diagnostics. Angew. Chem. Int. Ed. Engl. 56, 7112–7116 (2017).
Dixon, A. S. et al. NanoLuc complementation reporter optimized for accurate measurement of protein interactions in cells. ACS Chem. Biol. 11, 400–408 (2016).
Fraga, H., Fernandes, D., Fontes, R. & Esteves da Silva, J. C. Coenzyme A affects firefly luciferase luminescence because it acts as a substrate and not as an allosteric effector. FEBS J. 272, 5206–5216 (2005).
Hemmati, R. et al. Luciferin‐regenerating enzyme mediates firefly luciferase activation through direct effects of D‐cysteine on luciferase structure and activity. Photochem. Photobiol. 91, 828–836 (2015).
Dijkema, F. M. et al. Flash properties of Gaussia luciferase are the result of covalent inhibition after a limited number of cycles. Protein Sci. 30, 638–649 (2021).
Wang, L. et al. Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples. Nat. Biomed. Eng. 6, 276–285 (2022).
Agarwal, D. K. et al. Highly sensitive and ultra-rapid antigen-based detection of SARS-CoV-2 using nanomechanical sensor platform. Biosens. Bioelectron. 195, 113647 (2022).
Bokelmann, L. et al. Point-of-care bulk testing for SARS-CoV-2 by combining hybridization capture with improved colorimetric LAMP. Nat. Commun. 12, 1467 (2021).
Cutlan, R., De Rose, S., Isupov, M. N., Littlechild, J. A. & Harmer, N. J. Using enzyme cascades in biocatalysis: highlight on transaminases and carboxylic acid reductases. Biochim. Biophys. Acta 1868, 140322 (2020).
Kang, W. et al. Modular enzyme assembly for enhanced cascade biocatalysis and metabolic flux. Nat. Commun. 10, 4248 (2019).
Wu, S. et al. Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis. Nat. Commun. 7, 11917 (2016).
Zhang, Y., Ge, J. & Liu, Z. Enhanced activity of immobilized or chemically modified enzymes. ACS Catal. 5, 4503–4513 (2015).
Hervás, M., López, M. Á. & Escarpa, A. Electrochemical microfluidic chips coupled to magnetic bead-based ELISA to control allowable levels of zearalenone in baby foods using simplified calibration. Analyst 134, 2405–2411 (2009).
Lin, C.-T. et al. Hand-powered centrifugal microfluidic disc with magnetic chitosan bead-based ELISA for antibody quantitation. Sens. Actuators B 316, 128003 (2020).
Warmerdam, A., Boom, R. M. & Janssen, A. E. β-Galactosidase stability at high substrate concentrations. SpringerPlus 2, 402 (2013).
Suvarli, N. et al. Immobilization of β-galactosidase by encapsulation of enzyme-conjugated polymer nanoparticles inside hydrogel microparticles. Front. Bioeng. Biotechnol. 9, 818053 (2022).
Blomhoff, H. K., Blomhoff, R. & Christensen, T. B. Enhanced stability of β-galactosidase in parenchymal and nonparenchymal liver cells by conjugation with dextran. Biochim. Biophys. Acta 757, 202–208 (1983).
Benito, A., Feliu, J. X. & Villaverde, A. β-Galactosidase enzymatic activity as a molecular probe to detect specific antibodies. J. Biol. Chem. 271, 21251–21256 (1996).
Torgov, M. Y., Alley, S. C., Cerveny, C. G., Farquhar, D. & Senter, P. D. Generation of an intensely potent anthracycline by a monoclonal antibody−β-galactosidase conjugate. Bioconjug. Chem. 16, 717–721 (2005).
Feng, Y., Chang, X., Wang, W. & Ma, R. Stabilities of immobilized β-galactosidase of Aspergillus sp. AF for the optimal production of galactooligosaccharides from lactose. Artif. Cells Blood Substit. Immobil. Biotechnol. 38, 43–51 (2010).
Wehrman, T. S., von Degenfeld, G., Krutzik, P. O., Nolan, G. P. & Blau, H. M. Luminescent imaging of β-galactosidase activity in living subjects using sequential reporter-enzyme luminescence. Nat. Methods 3, 295–301 (2006).
Sellmyer, M. A. et al. Visualizing cellular interactions with a generalized proximity reporter. Proc. Natl Acad. Sci. USA 110, 8567–8572 (2013).
Porterfield, W. B., Jones, K. A., McCutcheon, D. C. & Prescher, J. A. A ‘caged’ luciferin for imaging cell–cell contacts. J. Am. Chem. Soc. 137, 8656–8659 (2015).
Zhang, Y. & Hess, H. Toward rational design of high-efficiency enzyme cascades. ACS Catal. 7, 6018–6027 (2017).
Li, J., Chen, L., Du, L. & Li, M. Cage the firefly luciferin!–a strategy for developing bioluminescent probes. Chem. Soc. Rev. 42, 662–676 (2013).
Jung, Y. K., Park, H. G. & Kim, J.-M. Polydiacetylene (PDA)-based colorimetric detection of biotin–streptavidin interactions. Biosens. Bioelectron. 21, 1536–1544 (2006).
Serrano-Plana, J. et al. Enantioselective hydroxylation of benzylic C (sp3)–H bonds by an artificial iron hydroxylase based on the biotin–streptavidin technology. J. Am. Chem. Soc. 142, 10617–10623 (2020).
Shrivastava, A. & Gupta, V. B. Methods for the determination of limit of detection and limit of quantitation of the analytical methods. Chron. Young Sci. 2, 21–25 (2011).
Armbruster, D. A. & Pry, T. Limit of blank, limit of detection and limit of quantitation. Clin. Biochem. Rev. 29, S49–S52 (2008).
Establishing the Performance Characteristics of In Vitro Diagnostic Devices for the Detection or Detection and Differentiation of Influenza Viruses—Guidance for Industry and FDA Staff (FDA, 2011); https://www.fda.gov/regulatory-information/search-fda-guidance-documents/establishing-performance-characteristics-in-vitro-diagnostic-devices-detection-or-detection-and
Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring (WHO, 2021); https://www.who.int/publications/i/item/9789240031593
Updated Recommendations on HIV Prevention, Infant Diagnosis, Antiretroviral Initiation and Monitoring (WHO, 2021); https://iris.who.int/bitstream/handle/10665/340190/9789240022232-eng.pdf?sequence=1
Stone, M. et al. Comparison of detection limits of fourth- and fifth-generation combination HIV antigen-antibody, p24 antigen, and viral load assays on diverse HIV isolates. J. Clin. Microbiol. 56, e02045-17 (2018).
Reyes, S. et al. An intact cell bioluminescence-based assay for the simple and rapid diagnosis of urinary tract infection. Int. J. Mol. Sci. 21, 5015–5028 (2020).
Liu, B.-F. et al. Microfluidic chip toward cellular ATP and ATP-conjugated metabolic analysis with bioluminescence detection. Anal. Chem. 77, 573–578 (2005).
Kim, S. B., Takenaka, Y. & Torimura, M. A bioluminescent probe for salivary cortisol. Bioconjug. Chem. 22, 1835–1841 (2011).
Nishihara, R. et al. Pseudo-luciferase activity of the SARS-CoV-2 spike protein for Cypridina luciferin. ACS Cent. Sci. 10, 283–290 (2024).