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Tuberculosis after allogeneic hematopoietic stem cell transplantation: a decade nationwide case-control retrospective study in low-incidence country

  • Global Tuberculosis Report 2022. Accessed August 30, 2023. https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022.

  • Gratwohl A, Brand R, Frassoni F, Rocha V, Niederwieser D, Reusser P, et al. Cause of death after allogeneic haematopoietic stem cell transplantation (HSCT) in early leukaemias: an EBMT analysis of lethal infectious complications and changes over calendar time. Bone Marrow Transpl. 2005;36:757–769. https://doi.org/10.1038/sj.bmt.1705140.

    Article 
    CAS 

    Google Scholar
     

  • Tomblyn M, Chiller T, Einsele H, Gress R, Sepkowitz K, Storek J, et al. Guidelines for Preventing Infectious Complications among Hematopoietic Cell Transplantation Recipients: a global perspective. Biol Blood Marrow Transpl. 2009;15:1143–1238. https://doi.org/10.1016/j.bbmt.2009.06.019.

    Article 
    CAS 

    Google Scholar
     

  • Cheng MP, Kusztos AE, Bold TD, Ho VT, Glotzbecker BE, Hsieh C, et al. Risk of latent tuberculosis reactivation after hematopoietic cell transplantation. Clin Infect Dis. 2019;69:869–872. https://doi.org/10.1093/cid/ciz048.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kapoor J, Mirgh SP, Khushoo V, Mehta P, Ahmed R, Bansal N, et al. Study of clinical characteristics, risk factors and outcomes for tuberculosis post-allogeneic stem cell transplant: never count it out. Ther Adv Infect Dis. 2021;8:204993612110086 https://doi.org/10.1177/20499361211008674.

    Article 

    Google Scholar
     

  • Zeng QZ, Zhang YY, Wu YJ, Zhang ZY, Zhang JN, Fu HX, et al. Frequency, risk factors, and outcome of active tuberculosis following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transpl. 2020;26:1203–9. https://doi.org/10.1016/j.bbmt.2020.02.018.

    Article 
    CAS 

    Google Scholar
     

  • de Oliveira Rodrigues M, de Almeida Testa LH, dos Santos ACF, Zanetti LP, da Silva Ruiz L, de Souza MP, et al. Latent and active tuberculosis infection in allogeneic hematopoietic stem cell transplant recipients: a prospective cohort study. Bone Marrow Transpl. 2021;56:2241–7. https://doi.org/10.1038/s41409-021-01329-3.

    Article 
    CAS 

    Google Scholar
     

  • Lee HJ, Lee DG, Choi SM, Park SH, Cho SY, Choi JK, et al. The demanding attention of tuberculosis in allogeneic hematopoietic stem cell transplantation recipients: High incidence compared with general population. PLoS ONE. 2017;12:e0173250. https://doi.org/10.1371/journal.pone.0173250.

  • Fan WC, Liu CJ, Hong YC, Feng JY, Su WJ, Chien SH, et al. Long-term risk of tuberculosis in haematopoietic stem cell transplant recipients: a 10-year nationwide study. Int J Tuberc Lung Dis. 2015;19:58–64. https://doi.org/10.5588/ijtld.14.0301.

    Article 
    PubMed 

    Google Scholar
     

  • Liu YC, Wu CJ, Ko PS, Chien SH, Fan NW, Wang HY, et al. Mycobacterial infections in adult recipients of allogeneic hematopoietic stem cell transplantation: a cohort study in a high-endemic area. J Microbiol Immunol Infect. 2020;53:274–82. https://doi.org/10.1016/j.jmii.2018.07.001.

    Article 
    PubMed 

    Google Scholar
     

  • Bergeron A, Mikulska M, Greef JD, Bondeelle L, Franquet T, Herrmann JL, et al. Mycobacterial infections in adults with haematological malignancies and haematopoietic stem cell transplants: guidelines from the 8th European Conference on Infections in Leukaemia. Lancet Infect Dis. 2022;0. https://doi.org/10.1016/S1473-3099(22)00227-4.

  • de Léotoing L, Barbier F, Dinh A, Breilh D, Chaize G, Vainchtock A, et al. French hospital discharge database (PMSI) and bacterial resistance: Is coding adapted to hospital epidemiology? Méd Mal Infect. 2018;48:465–73. https://doi.org/10.1016/j.medmal.2018.03.007.

    Article 
    PubMed 

    Google Scholar
     

  • Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transpl. 1995;15:825–8.

    CAS 

    Google Scholar
     

  • Shulman HM, Sullivan KM, Weiden PL, McDonald GB, Striker GE, Sale GE, et al. Chronic graft-versus-host syndrome in man. Am J Med. 1980;69:204–17. https://doi.org/10.1016/0002-9343(80)90380-0.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lee SJ, Vogelsang G, Flowers MED. Chronic graft-versus-host disease. Biol Blood Marrow Transpl. 2003;9:215–33. https://doi.org/10.1053/bbmt.2003.50026.

    Article 
    CAS 

    Google Scholar
     

  • Guidelines on the management of latent tuberculosis infection. Accessed June 22, 2023. https://www.who.int/publications-detail-redirect/9789241548908.

  • Yang A, Shi J, Luo Y, Ye Y, Tan Y, Huang H, et al. Allo-HSCT recipients with invasive fungal disease and ongoing immunosuppression have a high risk for developing tuberculosis. Sci Rep. 2019;9:20402. https://doi.org/10.1038/s41598-019-56013-w.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peer V, Schwartz N, Green MS Gender differences in tuberculosis incidence rates—A pooled analysis of data from seven high-income countries by age group and time period. Front Public Health. 2023;10. https://doi.org/10.3389/fpubh.2022.997025.

  • Zhang N, Wu J, Wang Q, Liang Y, Li X, Chen G, et al. Global burden of hematologic malignancies and evolution patterns over the past 30 years. Blood Cancer J. 2023;13:1–13. https://doi.org/10.1038/s41408-023-00853-3.

    Article 

    Google Scholar
     

  • Agrawal N, Aggarwal M, Kapoor J, Ahmed R, Shrestha A, Kaushik M, et al. Incidence and clinical profile of tuberculosis after allogeneic stem cell transplantation. Transpl Infect Dis. 2018;20:e12794. https://doi.org/10.1111/tid.12794.

    Article 

    Google Scholar
     

  • Maschmeyer G, De Greef J, Mellinghoff SC, Nosari A, Thiebaut-Bertrand A, Bergeron A, et al. Infections associated with immunotherapeutic and molecular targeted agents in hematology and oncology. A position paper by the European Conference on Infections in Leukemia (ECIL). Leukemia. 2019;33:844–62. https://doi.org/10.1038/s41375-019-0388-x.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bumbacea D, Arend SM, Eyuboglu F, Fishman JA, Goletti D, Ison MG, et al. The risk of tuberculosis in transplant candidates and recipients: a TBNET consensus statement. Eur Respir J. 2012;40:990–1013. https://doi.org/10.1183/09031936.00000712.

    Article 
    PubMed 

    Google Scholar
     

  • de la Cámara R, Martino R, Granados E, Rodríguez-Salvanés FJ, Rovira M, Cabrera R, et al. Tuberculosis after hematopoietic stem cell transplantation: incidence, clinical characteristics and outcome. Bone Marrow Transpl. 2000;26:291–8. https://doi.org/10.1038/sj.bmt.1702506.

    Article 

    Google Scholar
     

  • Gras J, De Castro N, Montlahuc C, Champion L, Scemla A, Matignon M, et al. Clinical characteristics, risk factors, and outcome of tuberculosis in kidney transplant recipients: A multicentric case-control study in a low-endemic area. Transpl Infect Dis. 2018;20:e12943. https://doi.org/10.1111/tid.12943.

    Article 
    PubMed 

    Google Scholar
     

  • Sartori NS, Picon P, Papke A, Neyeloff JL, da Silva Chakr RM. A population-based study of tuberculosis incidence among rheumatic disease patients under anti-TNF treatment. PLoS ONE. 2019;14:e0224963 https://doi.org/10.1371/journal.pone.0224963.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gómez-Reino JJ, Carmona L, Valverde VR, Mola EM, Montero MD. BIOBADASER Group. Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to a significant increase in tuberculosis risk: a multicenter active-surveillance report. Arthritis Rheum. 2003;48:2122–7. https://doi.org/10.1002/art.11137.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gupta RK, Rice B, Brown AE, Thomas HL, Zenner D, Anderson L, et al. Does antiretroviral therapy reduce HIV-associated tuberculosis incidence to background rates? A national observational cohort study from England, Wales, and Northern Ireland. Lancet HIV. 2015;2:e243–e251. https://doi.org/10.1016/S2352-3018(15)00063-6.

    Article 
    PubMed 

    Google Scholar
     

  • Winter JR, Stagg HR, Smith CJ, Brown AE, Lalor MK, Lipman M, et al. Injecting drug use predicts active tuberculosis in a national cohort of people living with HIV. AIDS. 2017;31:2403–13. https://doi.org/10.1097/QAD.0000000000001635.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Karo B, Haas W, Kollan C, Gunsenheimer-Bartmeyer B, Hamouda O, et al. Tuberculosis among people living with HIV/AIDS in the German ClinSurv HIV Cohort: long-term incidence and risk factors. BMC Infect Dis. 2014;14:148. https://doi.org/10.1186/1471-2334-14-148.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Turkova A, Chappell E, Judd A, Goodall RL, Welch SB, Foster C, et al. Prevalence, incidence, and associated risk factors of tuberculosis in children with HIV living in the UK and Ireland (CHIPS): a cohort study. Lancet HIV. 2015;2:e530–e539. https://doi.org/10.1016/S2352-3018(15)00200-3.

    Article 
    PubMed 

    Google Scholar
     

  • Martin-Iguacel R, Llibre JM, Pedersen C, Obel N, Stærke NB, Åhsberg J, et al. Tuberculosis incidence and mortality in people living with human immunodeficiency virus: a Danish nationwide cohort study. Clin Microbiol Infect. 2022;28:570–9. https://doi.org/10.1016/j.cmi.2021.07.036.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Abgrall S, Del Giudice P, Melica G, Costagliola D. FHDH-ANRS CO4. HIV-associated tuberculosis and immigration in a high-income country: incidence trends and risk factors in recent years. AIDS Lond Engl. 2010;24:763–71. https://doi.org/10.1097/QAD.0b013e3283366747.

    Article 

    Google Scholar
     

  • Lannoy LHde, Cortez-Escalante JJ, Evangelista MdoSN, Romero GAS. Tuberculosis incidence and risk factors among patients living with HIV/AIDS in public health service institutions in Brasilia, Federal District. Rev Soc Bras Med Trop. 2008;41:549–55. https://doi.org/10.1590/S0037-86822008000600001.

    Article 
    PubMed 

    Google Scholar
     

  • Al-Anazi K, Al-Jasser A, Evans D. Infections caused by Mycobacterium tuberculosis in patients with hematological disorders and in recipients of hematopoietic stem cell transplant, a twelve-year retrospective study. Ann Clin Microbiol Antimicrob. 2007;6:16 https://doi.org/10.1186/1476-0711-6-16.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kwon DE, Han SH, Han KD, La Y, Lee KH. Incidence rate of active tuberculosis in solid organ transplant recipients: data from a nationwide population cohort in a high-endemic country. Transpl Infect Dis. 2021;23:e13729. https://doi.org/10.1111/tid.13729.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Helleberg M, Cho D, Ekenberg C, Sørensen S, Rix M, Gustafsson F, et al. Tuberculosis among patients undergoing solid organ transplantation or dialysis in a low-endemic country, 2004–17. Tuberc Res Treat. 2020;2020:1–7. https://doi.org/10.1155/2020/7636975.

    Article 

    Google Scholar
     

  • Torre-Cisneros J, Doblas A, Aguado JM, San Juan R, Blanes M, Montejo M, et al. Tuberculosis after solid-organ transplant: incidence, risk factors, and clinical characteristics in the RESITRA (Spanish Network of Infection in Transplantation) Cohort. Clin Infect Dis. 2009;48:1657–65. https://doi.org/10.1086/599035.

    Article 
    PubMed 

    Google Scholar
     

  • Natori Y, Ferreira VH, Nellimarla S, Husain S, Rotstein C, Humar A, et al. Incidence, outcomes, and long-term immune response to tuberculosis in organ transplant recipients. Transplantation. 2019;103:210–5. https://doi.org/10.1097/TP.0000000000002340.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Liu J, Yan J, Wan Q, Ye Q, Huang Y. The risk factors for tuberculosis in liver or kidney transplant recipients. BMC Infect Dis. 2014;14:387. https://doi.org/10.1186/1471-2334-14-387.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Garces Ambrossi G, Jakubowski A, Feinstein MB, Weinstock DM. Active tuberculosis limited to foreign-born patients after allogeneic hematopoietic stem cell transplant. Bone Marrow Transpl. 2005;36:741–3. https://doi.org/10.1038/sj.bmt.1705129.

    Article 
    CAS 

    Google Scholar
     

  • Litvoc MN, Leal FE, Ferreira DB, Ferreira Lopes MIB, Capuani L, Rocha VG, et al. High tuberculosis density incidence rate in matched unrelated allogeneic stem cell transplantation recipients in the State of São Paulo, Brazil. Mediterr J Hematol Infect Dis. 2023;15:e2023037 https://doi.org/10.4084/MJHID.2023.037.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yoo JW, Jo KW, Kim SH, Lee SO, Kim JJ, Park SK, et al. Incidence, characteristics, and treatment outcomes of mycobacterial diseases in transplant recipients. Transpl Int. 2016;29:549–58. https://doi.org/10.1111/tri.12752.

    Article 
    PubMed 

    Google Scholar
     

  • Park SH, Choi SM, Lee DG, Choi JH, Yoo JH, Lee JW, et al. Current trends of infectious complications following hematopoietic stem cell transplantation in a single center. J Korean Med Sci. 2006;21:199–207. https://doi.org/10.3346/jkms.2006.21.2.199.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yoo JH, Lee DG, Choi SM, Choi JH, Park YH, Kim YJ, et al. Infectious complications and outcomes after allogeneic hematopoietic stem cell transplantation in Korea. Bone Marrow Transpl. 2004;34:497–504. https://doi.org/10.1038/sj.bmt.1704636.

    Article 

    Google Scholar
     

  • Lee J, Lee MH, Kim WS, Kim K, Park SH, Lee SH, et al. Tuberculosis in hematopoietic stem cell transplant recipients in Korea. Int J Hematol. 2004;79:185–8. https://doi.org/10.1532/IJH97.A10219.

    Article 
    PubMed 

    Google Scholar
     

  • George B, Mathews V, Srivastava A, Chandy M. Infections among allogeneic bone marrow transplant recipients in India. Bone Marrow Transpl. 2004;33:311–5. https://doi.org/10.1038/sj.bmt.1704347.

    Article 
    CAS 

    Google Scholar
     

  • Erdstein AA, Daas P, Bradstock KF, Robinson T, Hertzberg MS. Tuberculosis in allogeneic stem cell transplant recipients: still a problem in the 21st century. Transpl Infect Dis. 2004;6:142–6. https://doi.org/10.1111/j.1399-3062.2004.00068.x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Moon SM, Lee SO, Choi SH, Kim YS, Woo JH, Yoon DH, et al. Comparison of the QuantiFERON-TB Gold In-Tube test with the tuberculin skin test for detecting latent tuberculosis infection prior to hematopoietic stem cell transplantation. Transpl Infect Dis. 2013;15:104–9. https://doi.org/10.1111/j.1399-3062.2012.00765.x.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kumar R, Naithani R, Mishra P, Mahapatra M, Seth T, Dolai TK, et al. Allogeneic hematopoietic SCT performed in non-HEPA filter rooms: initial experience from a single center in India. Bone Marrow Transpl. 2009;43:115–9. https://doi.org/10.1038/bmt.2008.307.

    Article 
    CAS 

    Google Scholar
     

  • Ullah K, Raza S, Ahmed P, atti TM, Ikram A, Chaudhry QU, et al. Pulmonary tuberculosis in allogeneic stem cell transplant recipients. JPMA J Pak Med Assoc. 2007;57:567–9.

    PubMed 

    Google Scholar
     

  • Maeda T, Kusumi E, Kami M, Kawabata M, Le Pavoux A, Hara S, et al. Disseminated tuberculosis following reduced-intensity cord blood transplantation for adult patients with hematological diseases. Bone Marrow Transpl. 2005;35:91–97. https://doi.org/10.1038/sj.bmt.1704740.

    Article 
    CAS 

    Google Scholar
     

  • Ahmed P, Anwar M, Khan B, Altaf C, Ullah K, Raza S, et al. Role of isoniazid prophylaxis for prevention of tuberculosis in haemopoietic stem cell transplant recipients. J Pak Med Assoc. 2005;55. https://pubmed.ncbi.nlm.nih.gov/16302471/.

  • Ku SC, Tang JL, Hsueh PR, Luh KT, Yu CJ, Yang PC, et al. Pulmonary tuberculosis in allogeneic hematopoietic stem cell transplantation. Bone Marrow Transpl. 2001;27:1293–7. https://doi.org/10.1038/sj.bmt.1703092.

    Article 
    CAS 

    Google Scholar
     

  • Budak-Alpdogan T, Tangün Y, Kalayoglu-Besisik S, Ratip S, Akan H, Baslar Z, et al. The frequency of tuberculosis in adult allogeneic stem cell transplant recipients in Turkey. Biol Blood Marrow Transpl. 2000;6:370–4. https://doi.org/10.1016/S1083-8791(00)70013-9.

    Article 
    CAS 

    Google Scholar
     

  • Aljurf M, Gyger M, Alrajhi A, Sahovic E, Chaudhri N, Musa M, et al. Mycobacterium tuberculosis infection in allogeneic bone marrow transplantation patients. Bone Marrow Transpl. 1999;24:551–4. https://doi.org/10.1038/sj.bmt.1701930.

    Article 
    CAS 

    Google Scholar
     

  • Ip MSM, Yuen KY, Woo PCY, Luk WK, Tsang KW, Lam WK, et al. Risk factors for pulmonary tuberculosis in bone marrow transplant recipients. Am J Respir Crit Care Med. 1998;158:1173–7. https://doi.org/10.1164/ajrccm.158.4.9712072.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Roy V, Weisdorf D. Mycobacterial infections following bone marrow transplantation: a 20-year retrospective review. Bone Marrow Transpl. 1997;19:467–70. https://doi.org/10.1038/sj.bmt.1700686.

    Article 
    CAS 

    Google Scholar
     

  • Benito N, García-Vázquez E, Horcajada JP, González J, Oppenheimer F, Cofán F, et al. Clinical features and outcomes of tuberculosis in transplant recipients as compared with the general population: a retrospective matched cohort study. Clin Microbiol Infect. 2015;21:651–8. https://doi.org/10.1016/j.cmi.2015.03.010.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li T, Zhang B, Du X, Pei S, Jia Z, Zhao Y. Recurrent pulmonary tuberculosis in China, 2005 to 2021. JAMA Netw Open. 2024;7:e2427266 https://doi.org/10.1001/jamanetworkopen.2024.27266.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pai M, Denkinger CM, Kik SV, Rangaka MX, Zwerling A, Oxlade O, et al. Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev. 2014;27:3–20. https://doi.org/10.1128/CMR.00034-13.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mert D, Ozer M, Merdin A, İskender G, Uncu Ulu B, Kizil Çakar M, et al. Latent tuberculosis in adult hematopoietic stem cell transplantation recipients: clinical experience from a previously endemic population. Medicine. 2022;101:e31786 https://doi.org/10.1097/MD.0000000000031786.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bourlon C, Camacho-Hernández R, Fierro-Angulo OM, Acosta-Medina AA, Bourlon MT, Niembro-Ortega MD, et al. Latent tuberculosis in hematopoietic stem cell transplantation: diagnostic and therapeutic strategies to prevent disease activation in an endemic population. Biol Blood Marrow Transpl. 2020;26:1350–4. https://doi.org/10.1016/j.bbmt.2020.03.013.

    Article 

    Google Scholar
     

  • Lee YM, Lee SO, Choi SH, Kim YS, Woo JH, Kim DY, et al. A prospective longitudinal study evaluating the usefulness of the interferon-gamma releasing assay for predicting active tuberculosis in allogeneic hematopoietic stem cell transplant recipients. J Infect. 2014;69:165–73. https://doi.org/10.1016/j.jinf.2014.02.019.

    Article 
    PubMed 

    Google Scholar
     

  • Castro-Lima VAC, Santos APT, Musqueira PT, Maluf NZ, Ramos JF, Mariano L, et al. Prevalence of latent Mycobacterium tuberculosis infection in hematopoietic stem cell transplantation comparing tuberculin skin test and interferon-gamma release assay. Eur J Clin Microbiol Infect Dis. 2023;42:899–902. https://doi.org/10.1007/s10096-023-04613-w.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mahmoudi S, Pourakbari B, Sadeghi RH, Hamidieh AA, Safari Sharari A, Salajegheh P, et al. High prevalence of latent tuberculosis in hematopoietic stem cell transplant recipients: a first report. Pediatr Transpl. 2020;24:e13770. https://doi.org/10.1111/petr.13770.

    Article 

    Google Scholar
     

  • Akı ŞZ, Sucak GT, Tunçcan ÖG, Köktürk N, Şenol E. The incidence of tuberculosis infection in hematopoietic stem cell transplantation recipients: a retrospective cohort study from a center in Turkey. Transpl Infect Dis. 2018;20:e12912. https://doi.org/10.1111/tid.12912.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Compagno M, Navarra A, Campogiani L, Coppola L, Rossi B, Iannetta M, et al. Latent tuberculosis infection in haematopoietic stem cell transplant recipients: a retrospective Italian cohort study in Tor Vergata University Hospital, Rome. Int J Environ Res Public Health. 2022;19:10693 https://doi.org/10.3390/ijerph191710693.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lewalle P, Pochon C, Michallet M, Turlure P, Brissot E, Paillard C, et al. Prophylaxie des infections post-allogreffe: recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC). Bull Cancer. 2019;106:S23–S34. https://doi.org/10.1016/j.bulcan.2018.08.017.

    Article 
    PubMed 

    Google Scholar
     

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