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The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target TIM-1 to limit Zika virus infection

  • Liu Z-Y, Shi W-F, Qin C-F. The evolution of Zika virus from Asia to the Americas. Nat Rev Microbiol. 2019;17:131–9.

    CAS 
    PubMed 

    Google Scholar
     

  • Pierson TC, Diamond MS. The emergence of Zika virus and its new clinical syndromes. Nature. 2018;560:573–81.

    CAS 
    PubMed 

    Google Scholar
     

  • Lessler J, Chaisson LH, Kucirka LM, Bi Q, Grantz K, Salje H, et al. Assessing the global threat from Zika virus. Science. 2016;353:aaf8160.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mehand MS, Al-Shorbaji F, Millett P, Murgue B. The WHO R&D Blueprint: 2018 review of emerging infectious diseases requiring urgent research and development efforts. Antiviral Res. 2018;159:63–67.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV. Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int. 2002;62:237–44.

    CAS 
    PubMed 

    Google Scholar
     

  • Ichimura T, Bonventre JV, Bailly V, Wei H, Hession CA, Cate RL, et al. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J Biol Chem. 1998;273:4135–42.

    CAS 
    PubMed 

    Google Scholar
     

  • Li M, Ablan SD, Miao C, Zheng YM, Fuller MS, Rennert PD, et al. TIM-family proteins inhibit HIV-1 release. Proc Natl Acad Sci USA. 2014;111:E3699–3707.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bailly V, Zhang Z, Meier W, Cate R, Sanicola M, Bonventre JV, et al. Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem. 2002;277:39739–48.

    CAS 
    PubMed 

    Google Scholar
     

  • Bod L, Kye YC, Shi J, Torlai Triglia E, Schnell A, Fessler J, et al. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature. 2023;619:348–56.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Giraldo MI, Xia H, Aguilera-Aguirre L, Hage A, van Tol S, Shan C, et al. Envelope protein ubiquitination drives entry and pathogenesis of Zika virus. Nature. 2020;585:414–9.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu J, Quan Y, Tong H, Zhu Y, Shi X, Liu Y, et al. Insights into mosquito-borne arbovirus receptors. Cell Insight. 2024;3:100196.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, et al. Biology of Zika Virus Infection in Human Skin Cells. J Virol. 2015;89:8880–96.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu W, Tao J, Cao H, Zheng W, Zhang B, Zhang Y, et al. The HAVCR1-centric host factor network drives Zika virus vertical transmission. Cell Rep. 2025;44:115464.

    CAS 
    PubMed 

    Google Scholar
     

  • Kondratowicz AS, Lennemann NJ, Sinn PL, Davey RA, Hunt CL, Moller-Tank S, et al. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci USA. 2011;108:8426–31.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jemielity S, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, et al. TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLoS Pathog. 2013;9:e1003232.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin H, Li S, Shu HB. The membrane-associated MARCH E3 ligase family: emerging roles in immune regulation. Front Immunol. 2019;10:1751.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zheng C. The emerging roles of the MARCH ligases in antiviral innate immunity. Int J Biol Macromol. 2021;171:423–7.

    CAS 
    PubMed 

    Google Scholar
     

  • Chen R, Li M, Zhang Y, Zhou Q, Shu HB. The E3 ubiquitin ligase MARCH8 negatively regulates IL-1beta-induced NF-kappaB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. Proc Natl Acad Sci USA. 2012;109:14128–33.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin H, Gao D, Hu MM, Zhang M, Wu XX, Feng L, et al. MARCH3 attenuates IL-1beta-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI. Proc Natl Acad Sci USA. 2018;115:12483–8.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin H, Feng L, Cui KS, Zeng LW, Gao D, Zhang LX, et al. The membrane-associated E3 ubiquitin ligase MARCH3 downregulates the IL-6 receptor and suppresses colitis-associated carcinogenesis. Cell Mol Immunol. 2021;18:2648–59.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zeng LW, Feng L, Liu R, Lin H, Shu HB, Li S. The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation. Cell Mol Immunol. 2022;19:1117–29.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu R, Zeng LW, Li HF, Shi JG, Zhong B, Shu HB, et al. PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity. Cell Res. 2023;33:923–39.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Umthong S, Timilsina U, D’Angelo MR, Salka K, Stavrou S. MARCH2, a T cell specific factor that restricts HIV-1 infection. PLoS Pathog. 2024;20:e1012330.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Feng L, Li C, Zeng LW, Gao D, Sun YH, Zhong L, et al. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Ralpha. Sig Transduct Target Ther. 2022;7:21.

    CAS 

    Google Scholar
     

  • Gao D, Yi XM, Feng L, Li S, Shu HB. MARCH8 mediates K27-linked polyubiquitination of IL-7 receptor alpha to negatively regulate IL-7-triggered T cell homeostasis. J Immunol. 2024;213:1467–78.

    CAS 
    PubMed 

    Google Scholar
     

  • Sanjana NE, Shalem O, Zhang F. Improved vectors and genome-wide libraries for CRISPR screening. Nat Methods. 2014;11:783–4.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 2014;343:84–87.

    CAS 
    PubMed 

    Google Scholar
     

  • Chathuranga K, Kim TH, Lee H, Park JS, Kim JH, Chathuranga WAG, et al. Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2. EMBO J. 2020;39:e105139.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nakamura N. The role of the transmembrane RING finger proteins in cellular and organelle function. Membranes. 2011;1:354–93.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tabata T, Petitt M, Puerta-Guardo H, Michlmayr D, Wang C, Fang-Hoover J, et al. Zika virus targets different primary human placental cells, suggesting two routes for vertical transmission. Cell Host Microbe. 2016;20:155–66.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dejarnac O, Hafirassou ML, Chazal M, Versapuech M, Gaillard J, Perera-Lecoin M, et al. TIM-1 ubiquitination mediates dengue virus entry. Cell Rep. 2018;23:1779–93.

    CAS 
    PubMed 

    Google Scholar
     

  • Wang J, Jiang B, Wang K, Dai J, Dong C, Wang Y, et al. A cathelicidin antimicrobial peptide from Hydrophis cyanocinctus inhibits Zika virus infection by downregulating expression of a viral entry factor. J Biol Chem. 2022;298:102471.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fukuda H, Nakamura N, Hirose S. MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II. Journal Biochem. 2006;139:137–45.

    CAS 

    Google Scholar
     

  • Dukhovny A, Lamkiewicz K, Chen Q, Fricke M, Jabrane-Ferrat N, Marz M, et al. A CRISPR activation screen identifies genes that protect against Zika virus infection. Journal Virol. 2019;93:e00211–19.

    CAS 

    Google Scholar
     

  • Yang C, Xu H, Yang D, Xie Y, Xiong M, Fan Y, et al. A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury. Nat Commun. 2023;14:4261.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Umetsu SE, Lee WL, McIntire JJ, Downey L, Sanjanwala B, Akbari O, et al. TIM-1 induces T cell activation and inhibits the development of peripheral tolerance. Nat Immunol. 2005;6:447–54.

    CAS 
    PubMed 

    Google Scholar
     

  • de Souza AJ, Oriss TB, O’Malley KJ, Ray A, Kane LP. T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc Natl Acad Sci USA. 2005;102:17113–8.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang J, Qiao L, Hou Z, Luo G. TIM-1 promotes Hepatitis C virus cell attachment and infection. J Virol. 2017;91:e01583–16.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang X, Liang C, Wang H, Guo Z, Rong H, Pan J, et al. T-cell immunoglobulin and mucin domain 1 (TIM-1) is a functional entry factor for tick-borne encephalitis virus. Mbio. 2022;13:e0286021.

    PubMed 

    Google Scholar
     

  • Yi X-M, Lei Y-L, Li M, Zhong L, Li S. The monkeypox virus-host interplays. Cell Insight. 2024;3:100185.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao C, Chen J, Liu Z, Liang H, Chen X, Cheng L, et al. Activation of nicotinic acetylcholine receptor alpha7 subunit limits Zika viral infection via promoting autophagy and ferroptosis. Mol Ther. 2024;32:2641–61.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Reed LJ, Muench H. A simple method of estimating fifty per cent endpoints12. Am J Epidemiol. 1938;27:493–7.


    Google Scholar
     

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