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The antirheumatic drug sulfasalazine ameliorates acute renal failure (ARF) induced by polymyxin B

  • Falagas ME, Kasiakou SK. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis. 2005;40:1333–41.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect. 2012;18:268–81.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Davis SD, Iannetta A, Wedgwood RJ. Activity of colistin against Pseudomonas aeruginosa: inhibition by calcium. J Infect Dis. 1971;124:610–2.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gupta S, Govil D, Kakar PN, Prakash O, Arora D, Das S, et al. Colistin and polymyxin B: a re-emergence. Indian J Crit Care Med. 2009;13:49–53.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kallel H, Hamida CB, Ksibi H, Bahloul M, Hergafi L, Chaari A, et al. Suspected acute interstitial nephritis induced by colistin. J Nephrol. 2005;18:323–6.

    PubMed 

    Google Scholar
     

  • Avedissian SN, Liu J, Rhodes NJ, Lee A, Pais GM, Hauser AR, et al. A Review of the Clinical Pharmacokinetics of Polymyxin B. Antibiotics (Basel). 2019;8:31.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yokosawa T, Yamada M, Noguchi T, Suzuki S, Hirata Y, Matsuzawa A. Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation. J Antibiot (Tokyo). 2019;72:848–52.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kagi T, Naganuma R, Inoue A, Noguchi T, Hamano S, Sekiguchi Y, et al. The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages. J Antibiot (Tokyo). 2022;75:29–39.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kagi T, Inoue A, Noguchi T, Suzuki W, Takano S, Otani K, et al. The NLRP3 Inflammasome Is a Major Cause of Acute Renal Failure Induced by Polypeptide Antibiotics. J Immunol. 2024;212:1807–18.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jo EK, Kim JK, Shin DM, Sasakawa C. Molecular mechanisms regulating NLRP3 inflammasome activation. Cell Mol Immunol. 2016;13:148–59.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Huang Z, Yu M, Tong S, Jia K, Liu R, Wang H, et al. Tissue-specific expression of the NOD-like receptor protein 3 in BALB/c mice. J Vet Sci. 2014;15:173–7.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tsai PY, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, et al. Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radic Biol Med. 2011;51:744–54.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mantovani A, Dinarello CA, Molgora M, Garlanda C. Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Immunity. 2019;50:778–95.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Noguchi T, Sekiguchi Y, Kudoh Y, Naganuma R, Kagi T, Nishidate A, et al. Gefitinib initiates sterile inflammation by promoting IL-1beta and HMGB1 release via two distinct mechanisms. Cell Death Dis. 2021;12:49.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sekiguchi Y, Takano S, Noguchi T, Kagi T, Komatsu R, Tan M, et al. The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases. J Immunol. 2023;210:795–806.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kagi T, Noguchi T, Matsuzawa A. Mechanisms of gefitinib-induced interstitial pneumonitis: why and how the TKI perturbs innate immune systems?. Oncotarget. 2021;12:1321–2.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kagi T, Tan M, Suzuki W, Otani K, Suzuki S, Hirata Y, et al. Benzalkonium chloride initiates proinflammatory responses via NLRP3 inflammasome activation. J Toxicol Sci. 2025;50:11–21.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kim HY, Choi YJ, Kim SK, Kim H, Jun DW, Yoon K, et al. Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome. Commun Biol. 2021;4:824.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gan HT, Chen YQ, Ouyang Q. Sulfasalazine inhibits activation of nuclear factor-κB in patients with ulcerative colitis. J Gastroen Hepatol. 2005;20:1016–24.

    Article 
    CAS 

    Google Scholar
     

  • Liu X, Zhang Y, Zhuang L, Olszewski K, Gan B. NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation. Genes Dis. 2021;8:731–45.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

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