“Saturday Night Live” took a swing at Kristi Noem this weekend … zeroing in on her husband’s alleged secret life in a headline-grabbing Weekend Update segment.

Cast member Sarah Sherman appeared as Bryon Noem, decked out in tight pink biker shorts and exaggerated fake breasts … a clear jab at a Daily Mail report claiming the former South Dakota governor’s husband dabbled in a so-called “bimbofication” fetish.

Sherman didn’t hold back … joking to Michael Che … “My eyes are up here, my nipples are out here,” and daring anyone to kink shame her on national TV.

The sketch also dragged Kristi into the mix — referencing her past controversy over shooting her dog — when another cast member popped in portraying her with a rifle, quipping … “Did someone say puppies?”

The bit was inspired by a report published last week alleging Bryon snapped photos of himself in women’s clothing with oversized fake breasts and chatted with adult performers about their surgically enhanced bodies — even allegedly saying he wanted “huge, huge ridiculous boobs.”

Kristi’s camp responded to the report, telling the New York Post she’s “devastated,” adding in a statement, “The family was blindsided by this, and they ask for privacy and prayers at the time.”