Melissa Barrera just slaughtered the “Scream” franchise … because the actress went scorched earth on the series after she was fired for comments on the Gaza War.

In an interview with Variety … Melissa didn’t hold back when she was asked about the success of the most recent flick … which was panned by critics — but made a boatload of money. MB straight up accused Paramount of inflating the box office numbers … saying there’s no way the film did so well.

As you know … Melissa was booted from “Scream 7” and left her talent agent after friction from her pro-Palestinian messages on social media when the war broke out … comparing Gaza to a concentration camp.

And the actress didn’t stop there in the interview, she twisted the knife on cast members who returned to the franchise after she got the boot … basically saying they should be ashamed. Returning OGs included Mason Gooding, Neve Campbell, and Matthew Lillard.

Melissa says she may be done with “Scream,” but it’s not done with her … because after every Tony-nominated performance of “Titanique” on Broadway — she was asked by fans to sign mainly “Scream” merch.