A shocking new twist has unraveled in the disappearance of “TODAY” host Savannah Guthrie‘s kidnapped mother Nancy Guthrie — Nancy’s son-in-law allegedly may become a suspect.

Thomas Cion — the husband of Savannah’s sister Annie — “may be a prime suspect” in the shocking case, according to Ashleigh Banfield … though we don’t know why. Ashleigh reported the stunning possibility on Tuesday’s episode of “Drop Dead Serious” and cited a source with “impeccable credentials.”

The veteran journalist also reported Annie’s car has been towed and is being used as evidence in the ongoing investigation … and that all the cameras at Nancy’s Tucson, Arizona home were smashed in.

This is yet another bombshell development in the riveting case — on Tuesday, reports that blood was found in Nancy’s residence circulated, and video from her front steps show a trail of blood drops leading from her door.

TMZ also obtained a ransom note — which is currently unverified — that we forwarded to detectives.

The devastating situation has had audiences’ eyes peeled since 84-year-old Nancy was first reported missing on Sunday. She was last seen Saturday night by family … and authorities believe she was taken against her will.