Wang, Y. et al. Traditional Chinese medicine in the treatment of chronic kidney diseases: Theories, applications, and mechanisms. Front. Pharmacol. 13, 917975 (2022).
Fu, R. et al. The Yin and Yang of traditional Chinese and Western medicine. Med. Res. Rev. 41, 3182–3200 (2021).
Ni, L. et al. Combating COVID-19 with integrated traditional Chinese and western medicine in China. Acta Pharm. Sin B 10, 1149–1162 (2020).
Zhao, W. et al. Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi-active components combination. Med. Res. Rev. 43, 1778–1808 (2023).
Li, J. et al. High degree of pharmacokinetic compatibility exists between the five-herb medicine XueBiJing and antibiotics comedicated in sepsis care. Acta Pharm. Sin B 9, 1035–1049 (2019).
Liu, S. et al. Effect of an Herbal-Based injection on 28-Day mortality in patients with sepsis: The EXIT-SEP randomized clinical trial. JAMA Intern. Med. 183, 647–655 (2023).
Guo, J., Zhu, J., Wang, Q., Wang, J. & Jia, Y. Comparative efficacy of seven kinds of Chinese medicine injections in acute lung injury and acute respiratory distress syndrome: A network Meta-analysis of randomized controlled trials. Front. Pharmacol. 12, 627751 (2021).
Su, Y., Zhang, Y., Yuan, H. & Shen, C. Efficacy of Xuebijing combined with ulinastatin in the treatment of traumatic sepsis and effects on inflammatory factors and immune function in patients. Front. Surg. 9, 899753 (2022).
Yao, R. Q. et al. Influence of Xuebijing injection and its component paeoniflorin on immune function and survival rate of septic rats. Zhonghua Shao Shang Za Zhi 36, 658–664 (2020).
Lin, C. et al. TLR4 biased small molecule modulators. Pharmacol. Ther. 228, 107918 (2021).
Wang, Y. et al. Small-molecule modulators of Toll-like receptors. Acc. Chem. Res. 53, 1046–1055 (2020).
Wang, Y. et al. Toll-like receptor 4-mediated endoplasmic reticulum stress induces intestinal paneth cell damage in mice following CLP-induced sepsis. Sci. Rep. 12, 15256 (2022).
Liu, M. W., Wang, Y. H., Qian, C. Y. & Li, H. Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating toll-interacting protein expression in rats with sepsis. Int. J. Mol. Med. 34, 1492–1504 (2014).
Kang, X. F. et al. Xuebijing injection protects sepsis induced myocardial injury by mediating TLR4/NF-kappaB/IKKalpha and JAK2/STAT3 signaling pathways. Aging (Albany NY) 15, 8501–8517 (2023).
Osterhout, J. A. et al. A preoptic neuronal population controls fever and appetite during sickness. Nature 606, 937–944 (2022).
Li, W. et al. Anti-depressive-like behaviors of APN KO mice involve Trkb/BDNF signaling related neuroinflammatory changes. Mol. Psychiatry 27, 1047–1058 (2022).
Takatani, Y. et al. Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration. Lab. Invest. 98, 629–639 (2018).
Zhang, J., Zhang, Q., Liu, G. & Zhang, N. Therapeutic potentials and mechanisms of the Chinese traditional medicine Danshensu. Eur. J. Pharmacol. 864, 172710 (2019).
Fu, Y. et al. Salvianolic acid B attenuates liver fibrosis by targeting Ecm1 and inhibiting hepatocyte ferroptosis. Redox Biol. 69, 103029 (2024).
Liu, J. et al. Novel ligustilide derivatives target quorum sensing system LasR/LasB and relieve inflammatory response against Pseudomonas aeruginosa infection. Eur. J. Med. Chem. 263, 115972 (2024).
Yan, K. et al. Safflower yellow and its main component HSYA alleviate diet-Induced obesity in mice: Possible involvement of the increased antioxidant enzymes in liver and adipose tissue. Front. Pharmacol. 11, 482 (2020).
Wang, X. T. et al. Paeoniflorin and hydroxysafflor yellow A in Xuebijing injection attenuate sepsis-Induced cardiac dysfunction and inhibit proinflammatory cytokine production. Front. Pharmacol. 11, 614024 (2020).
Li, S. et al. Suxiao Jiuxin pill attenuates acute myocardial ischemia via regulation of coronary artery tone. Front. Pharmacol. 14, 1104243 (2023).
Gao, J. et al. A prospective multicenter clinical study of Xuebijing injection in the treatment of sepsis and multiple organ dysfunction syndrome. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 27, 465–470 (2015).
Luan, X., Zhang, X., Nie, M. & Zhao, Y. Traditional Chinese medicine integrated responsive microneedles for systemic sclerosis treatment. Research (Wash D C) 6, 0141 (2023).
Li, B. et al. Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling. J. Pharm. Anal. 14, 100915 (2024).
Wang, J., Luo, C., Luo, M., Zhou, S. & Kuang, G. Targets and mechanisms of Xuebijing in the treatment of acute kidney injury associated with sepsis: A network pharmacology-based study. Curr. Comput. Aided Drug Des. 20, 752–763 (2024).
Li, H. et al. Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling. Innovation (Camb) 2, 100111 (2021).
Chou, T. C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol. Rev. 58, 621–681 (2006).
