Dheda, K., Barry, C. E. & Maartens, G. Tuberculosis. Lancet 387, 1211–1226 (2016).
Pai, M. et al. Tuberculosis. Nat. Rev. Dis. Primers 2, 16076 (2016).
Getahun, H., Matteelli, A., Chaisson Richard, E. & Raviglione, M. Latent Mycobacterium tuberculosis infection. N. Engl. J. Med. 372, 2127–2135 (2015).
Global Tuberculosis Report 2022 https://www.who.int/publications/i/item/9789240061729 (World Health Organization, 2022).
Fenaroli, F. et al. Enhanced permeability and retention-like extravasation of nanoparticles from the vasculature into tuberculosis granulomas in zebrafish and mouse models. ACS Nano 12, 8646–8661 (2018).
Prabhu, P. et al. Mannose-conjugated chitosan nanoparticles for delivery of rifampicin to Osteoarticular tuberculosis. Drug Deliv. Transl. Res. 11, 1509–1519 (2021).
Khawbung, J. L., Nath, D. & Chakraborty, S. Drug resistant tuberculosis: a review. Comp. Immunol. Microb. 74, 101574 (2021).
Hoagland, D. T., Liu, J., Lee, R. B. & Lee, R. E. New agents for the treatment of drug-resistant Mycobacterium tuberculosis. Adv. Drug Deliv. Rev. 102, 55–72 (2016).
Diacon Andreas, H. et al. Multidrug-resistant tuberculosis and culture conversion with bedaquiline. N. Engl. J. Med. 371, 723–732 (2014).
Conradie, F. et al. Treatment of highly drug-resistant pulmonary tuberculosis. N. Engl. J. Med. 382, 893–902 (2020).
Zhang, Z. et al. The fast-growing field of photo-driven theranostics based on aggregation-induced emission. Chem. Soc. Rev. 51, 1983–2030 (2022).
Feng, G., Zhang, G. Q. & Ding, D. Design of superior phototheranostic agents guided by Jablonski diagrams. Chem. Soc. Rev. 49, 8179–8234 (2020).
Li, X., Lovell, J. F., Yoon, J. & Chen, X. Clinical development and potential of photothermal and photodynamic therapies for cancer. Nat. Rev. Clin. Oncol. 17, 657–674 (2020).
Hu, W., Prasad, P. N. & Huang, W. Manipulating the dynamics of dark excited states in organic materials for phototheranostics. Acc. Chem. Res. 54, 697–706 (2021).
Yang, Z. & Chen, X. Semiconducting perylene diimide nanostructure: multifunctional phototheranostic nanoplatform. Acc. Chem. Res. 52, 1245–1254 (2019).
Li, H., Kim, Y., Jung, H., Hyun, J. Y. & Shin, I. Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy. Chem. Soc. Rev. 51, 8957–9008 (2022).
Cheng, P. & Pu, K. Molecular imaging and disease theranostics with renal-clearable optical agents. Nat. Rev. Mater. 6, 1095–1113 (2021).
Zhen, X. et al. Macrotheranostic probe with disease-activated near-infrared fluorescence, photoacoustic, and photothermal signals for imaging-guided therapy. Angew. Chem. Int. Ed. 57, 7804–7808 (2018).
Cai, Y. et al. Organic dye based nanoparticles for cancer phototheranostics. Small 14, 1704247 (2018).
Wang, F., Zhong, Y., Bruns, O., Liang, Y. & Dai, H. In vivo NIR-II fluorescence imaging for biology and medicine. Nat. Photonics 18, 535–547 (2024).
Wang, F. et al. In vivo non-invasive confocal fluorescence imaging beyond 1,700 nm using superconducting nanowire single-photon detectors. Nat. Nanotechnol. 17, 653–660 (2022).
Chen, Y., Wang, S. & Zhang, F. Near-infrared luminescence high-contrast in vivo biomedical imaging. Nat. Rev. Bioeng. 1, 60–78 (2023).
Zhao, H. et al. Near-infrared II fluorescence-guided glioblastoma surgery targeting monocarboxylate transporter 4 combined with photothermal therapy. eBioMedicine 106, 10524 (2024).
Yan, D. et al. An all-rounder for NIR-II phototheranostics: well-tailored 1064 nm-excitable molecule for photothermal combating of orthotopic breast cancer. Angew. Chem. Int. Ed. 63, e202401877 (2024).
Chen, Y., Yang, Y. & Zhang, F. Noninvasive in vivo microscopy of single neutrophils in the mouse brain via NIR-II fluorescent nanomaterials. Nat. Protoc. 19, 2386–2407 (2024).
Caspar, J. V. & Meyer, T. J. Application of the energy gap law to nonradiative, excited-state decay. J. Phys. Chem. 87, 952–957 (1983).
Wei, Y.-C. et al. Overcoming the energy gap law in near-infrared OLEDs by exciton–vibration decoupling. Nat. Photonics 14, 570–577 (2020).
Ding, Q. et al. Diverse interactions between AIEgens and biomolecules/organisms: advancing from strategic design to precision theranostics. Chem 10, 2031–2073 (2024).
Wang, H. et al. Aggregation-induced emission (AIE), life and health. ACS Nano 17, 14347–14405 (2023).
Kenry & Liu, B. Enhancing the theranostic performance of organic photosensitizers with aggregation-induced emission. Acc. Mater. Res. 3, 721–734 (2022).
Kang, M. et al. Aggregation‐enhanced theranostics: AIE sparkles in biomedical field. Aggregate 1, 80–106 (2020).
Mei, J., Leung, N. L., Kwok, R. T., Lam, J. W. & Tang, B. Z. Aggregation-induced emission: together we shine, united we soar! Chem. Rev. 115, 11718–11940 (2015).
Gui, Y. et al. Thiophene π-bridge manipulation of NIR-II AIEgens for multimodal tumor phototheranostics. Angew. Chem. Int. Ed. 63, e202318609 (2024).
Xu, C. et al. Molecular motion and nonradiative decay: towards efficient photothermal and photoacoustic systems. Angew. Chem. Int. Ed. 61, e202204604 (2022).
Yan, D. et al. Adding flying wings: butterfly-shaped NIR-II AIEgens with multiple molecular rotors for photothermal combating of bacterial biofilms. J. Am. Chem. Soc. 145, 25705–25715 (2023).
Gao, H. et al. Boosting photoacoustic effect via intramolecular motions amplifying thermal-to-acoustic conversion efficiency for adaptive image-guided cancer surgery. Angew. Chem. Int. Ed. 60, 21047–21055 (2021).
Fang, R. H., Kroll, A. V., Gao, W. & Zhang, L. Cell membrane coating nanotechnology. Adv. Mater. 30, 1706759 (2018).
Hu, C.-M. J. et al. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc. Natl Acad. Sci. USA 108, 10980–10985 (2011).
Zeng, Z. & Pu, K. Improving cancer immunotherapy by cell membrane-camouflaged nanoparticles. Adv. Funct. Mater. 30, 2004397 (2020).
Li, J. et al. Cell membrane coated semiconducting polymer nanoparticles for enhanced multimodal cancer phototheranostics. ACS Nano 12, 8520–8530 (2018).
Krishnan, N. et al. A modular approach to enhancing cell membrane-coated nanoparticle functionality using genetic engineering. Nat. Nanotechnol. 19, 345–353 (2024).
Li, Z., Tang, B. Z. & Wang, D. Bioinspired AIE nanomedicine: a burgeoning technology for fluorescence bioimaging and phototheranostics. Adv. Mater. 36, 2406047 (2024).
Dai, J. et al. Red blood cell membrane-camouflaged nanoparticles loaded with AIEgen and Poly(I : C) for enhanced tumoral photodynamic-immunotherapy. Natl Sci. Rev. 8, nwab03 (2021).
Cui, J. et al. ‘Trojan horse’ phototheranostics: fine-engineering NIR-II AIEgen camouflaged by cancer cell membrane for homologous-targeting multimodal imaging-guided phototherapy. Adv. Mater. 35, 2302639 (2023).
Li, B. et al. Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles. Nat. Nanotechnol. 19, 834–845 (2024).
Jiang, Z. M. et al. Development of genetically engineered iNKT cells expressing TCRs specific for the M. tuberculosis 38-kDa antigen. J. Transl. Med. 13, 141 (2015).
Shi, C. et al. Lipophilic AIEgens as the ‘trojan horse’ with discrepant efficacy in tracking and treatment of mycobacterial infection. Adv. Healthc. Mater. 13, 2301746 (2023).
Fan, S. et al. Photothermal and host immune activated therapy of cutaneous tuberculosis using macrophage targeted mesoporous polydopamine nanoparticles. Mater. Today Bio 28, 101232 (2024).
Coler, R. N. et al. The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial. npj Vaccines 3, 34 (2018).
Wang, H. et al. NIR-II AIE luminogen-based erythrocyte-like nanoparticles with granuloma-targeting and self-oxygenation characteristics for combined phototherapy of tuberculosis. Adv. Mater. 36, 2406143 (2024).
Xu, Z. et al. Nanofiber-mediated sequential photothermal antibacteria and macrophage polarization for healing MRSA-infected diabetic wounds. J. Nanobiotechnol. 19, 404 (2021).
Faa, G., Gerosa, C., Fanni, D., Lachowicz, J. I. & Nurchi, V. M. Gold-old drug with new potentials. Curr. Med. Chem. 25, 75–84 (2018).
Mosser, D. M. & Edwards, J. P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958–969 (2008).
Kawai, T. & Akira, S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34, 637–650 (2011).
Wang, W. et al. Macrophage-derived biomimetic nanoparticles for light-driven theranostics toward Mpox. Matter 7, 1187–1206 (2024).
Gawne, P. J., Ferreira, M., Papaluca, M., Grimm, J. & Decuzzi, P. New opportunities and old challenges in the clinical translation of nanotheranostics. Nat. Rev. Mater. 8, 783–798 (2023).
Okuda, Y., Lakshmikantham, M. V. & Cava, M. P. A new route to 1,3-disubstituted benzo[c]thiophenes. J. Org. Chem. 56, 6024–6026 (1991).
Yan, D. et al. Multimodal imaging-guided photothermal immunotherapy based on a versatile NIR-II aggregation-induced emission luminogen. Angew. Chem. Int. Ed. 61, e202202614 (2022).
Wang, M. et al. A versatile 980 nm absorbing aggregation-induced emission luminogen for NIR-II imaging-guided synergistic photo-immunotherapy against advanced pancreatic cancer. Adv. Funct. Mater. 32, 2205371 (2022).
