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IgA-driven neutrophil activation underlies severe dengue disease after primary Zika virus infection in humans

  • Bhatt, S. et al. The global distribution and burden of dengue. Nature 496, 504–507 (2013).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Paz-Bailey, G., Adams, L. E., Deen, J., Anderson, K. B. & Katzelnick, L. C. Dengue. Lancet 403, 667–682 (2024).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Katzelnick, L. C. et al. Antibody-dependent enhancement of severe dengue disease in humans. Science 358, 929–932 (2017).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Katzelnick, L. C. et al. Zika virus infection enhances future risk of severe dengue disease. Science 369, 1123–1128 (2020).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zambrana, J. V. et al. Primary exposure to Zika virus is linked with increased risk of symptomatic dengue virus infection with serotypes 2, 3, and 4, but not 1. Sci. Transl. Med. 16, 2199 (2024).


    Google Scholar
     

  • Estofolete, C. F. et al. Influence of previous Zika virus infection on acute dengue episode. PLoS Negl. Trop. Dis. 17, e0011710 (2023).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yamanaka, A. et al. Antibody-dependent enhancement representing in vitro infective progeny virus titer correlates with the viremia level in dengue patients. Sci. Rep. 11, 12354 (2021).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Waggoner, J. J. et al. Antibody-dependent enhancement of severe disease is mediated by serum viral load in pediatric dengue virus infections. J. Infect. Dis. 221, 1846–1854 (2020).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bournazos, S. et al. Antibody fucosylation predicts disease severity in secondary dengue infection. Science 372, 1102–1105 (2021).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yamin, R. et al. Human FcγRIIIa activation on splenic macrophages drives dengue pathogenesis in mice. Nat. Microbiol 8, 1468–1479 (2023).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gordon, A. et al. The Nicaraguan Pediatric Dengue Cohort Study: incidence of inapparent and symptomatic dengue virus infections, 2004–2010. PLoS Negl. Trop. Dis. 7, e2462 (2013).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bos, S. et al. Serotype-specific epidemiological patterns of inapparent versus symptomatic primary dengue virus infections: a 17-year cohort study in Nicaragua. Lancet Infect. Dis. 25, 346–356 (2025).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Perciani, C. T., Peixoto, P. S., Dias, W. O., Kubrusly, F. S. & Tanizaki, M. M. Improved method to calculate the antibody avidity index. J. Clin. Lab. Anal. 21, 201–206 (2007).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shackelford, P. G., Granoff, D. M., Madassery, J. V., Scott, M. G. & Nahm, M. H. Clinical and immunologic characteristics of healthy children with subnormal serum concentrations of IgG2. Pediatr. Res 27, 16–21 (1990).

    PubMed 

    Google Scholar
     

  • Plebani, A. et al. Serum IgG subclass concentrations in healthy subjects at different age: age normal percentile charts. Eur. J. Pediatr. 149, 164–167 (1989).

    PubMed 

    Google Scholar
     

  • Steffen, U. et al. IgA subclasses have different effector functions associated with distinct glycosylation profiles. Nat. Commun. 11, 120 (2020).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mayer-Hain, S. et al. Systemic activation of neutrophils by immune complexes is critical to IgA vasculitis. J. Immun. 209, 1048–1058 (2022).

    PubMed 

    Google Scholar
     

  • Pillebout, E. IgA vasculitis and IgA nephropathy: same disease? J. Clin. Med. 10, 2310 (2021).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aroca-Crevillén, A., Vicanolo, T., Ovadia, S. & Hidalgo, A. Neutrophils in physiology and pathology. Annu Rev. Pathol. 19, 227–259 (2024).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dias, A. G. et al. Antibody Fc characteristics and effector functions correlate with protection from symptomatic dengue virus type 3 infection. Sci. Transl. Med. 14, 3151 (2022).


    Google Scholar
     

  • Strich, J. R. et al. Fostamatinib inhibits neutrophils extracellular traps induced by COVID-19 patient plasma: a potential therapeutic. J. Infect. Dis. 223, 981–984 (2021).

    PubMed 

    Google Scholar
     

  • Narvaez, F. et al. Dengue severity by serotype and immune status in 19 years of pediatric clinical studies in Nicaragua. PLoS Negl. Trop. Dis. 19, e0012811 (2025).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Colbert, J. A. et al. Ultrasound measurement of gallbladder wall thickening as a diagnostic test and prognostic indicator for severe dengue in pediatric patients. Pediatr. Infect. Dis. J. 26, 850–852 (2007).

    PubMed 

    Google Scholar
     

  • Ferreira, B. D. C. & Correia, D. Ultrasound assessment of hepatobiliary and splenic changes in patients with dengue and warning signs during the acute and recovery phases. J. Ultrasound Med 38, 2015–2024 (2019).

    PubMed 

    Google Scholar
     

  • Srikiatkhachorn, A. et al. Natural history of plasma leakage in dengue hemorrhagic fever. Pediatr. Infect. Dis. J. 26, 283–290 (2007).

    PubMed 

    Google Scholar
     

  • Ruchusatsawat, K. et al. Long-term circulation of Zika virus in Thailand: an observational study. Lancet Infect. Dis. 19, 439–446 (2019).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Monteiro, R. C. & Suzuki, Y. Are there animal models of IgA nephropathy? Semin. Immunopathol. 43, 639–648 (2021).

    PubMed 

    Google Scholar
     

  • Seminario, G. et al. The Latin American Society for Immunodeficiencies Registry. J. Clin. Immunol. 45, 28 (2024).

    PubMed 

    Google Scholar
     

  • Wang, Z. et al. Enhanced SARS-CoV-2 neutralization by dimeric IgA. Sci. Transl. Med. 13, 1555 (2021).


    Google Scholar
     

  • Wegman, A. D. et al. DENV-specific IgA contributes protective and non-pathologic function during antibody-dependent enhancement of DENV infection. PLoS Pathog. 19, e1011616 (2023).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Upadhaya, B. K. et al. Transient IgA nephropathy with acute kidney injury in a patient with dengue fever. Saudi J. Kidney Dis. Transpl. 21, 521–5 (2010).

    PubMed 

    Google Scholar
     

  • Bachal, R. et al. Higher levels of dengue-virus-specific IgG and IgA during pre-defervescence associated with primary dengue hemorrhagic fever. Arch. Virol. 160, 2435–2443 (2015).

    PubMed 

    Google Scholar
     

  • Chia, P. Y., Teo, A. & Yeo, T. W. Association of neutrophil mediators with dengue disease severity and cardiac impairment in adults. J. Infect. Dis. 226, 1974–1984 (2022).

    PubMed 

    Google Scholar
     

  • Loke, P. et al. Gene expression patterns of dengue virus-infected children from Nicaragua reveal a distinct signature of increased metabolism. PLoS Negl. Trop. Dis. 4, e710 (2010).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Recker, M. et al. Markers of prolonged hospitalisation in severe dengue. PLoS Negl. Trop. Dis. 18, e0011922 (2024).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Robinson, M. et al. A 20-gene set predictive of progression to severe dengue. Cell Rep. 26, 1104–1111 (2019).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu, Y. E. et al. An 8-gene machine learning model improves clinical prediction of severe dengue progression. Genome Med. 14, 33 (2022).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Duggal, S. et al. Dengue virus infection in mice induces bone marrow myeloid cell differentiation and generates Ly6Glow immature neutrophils with modulated functions. J. Leukoc. Biol. 115, 130–148 (2024).

    PubMed 

    Google Scholar
     

  • Stacey, H. D. et al. IgA potentiates NETosis in response to viral infection. Proc. Natl Acad. Sci. USA 118, e2101497118 (2021).

  • Gimpel, A.-K. et al. IgA complexes induce neutrophil extracellular trap formation more potently than IgG complexes. Front. Immunol. 12, 761816 (2021).

    PubMed 

    Google Scholar
     

  • Allen, K. C. et al. SARS-CoV-2 immune complex–mediated neutrophil activation. Open Forum Infect. Dis. 12, ofaf199 (2025).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Knackstedt, S. L. et al. Neutrophil extracellular traps drive inflammatory pathogenesis in malaria. Sci. Immunol. 4, 336 (2019).


    Google Scholar
     

  • Passelli, K. et al. The c-MET receptor tyrosine kinase contributes to neutrophil-driven pathology in cutaneous leishmaniasis. PLoS Pathog. 18, e1010247 (2022).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Biering, S. B. et al. Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. Science 371, 194–200 (2021).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Modhiran, N. et al. A broadly protective antibody that targets the flavivirus NS1 protein. Science 371, 190–194 (2021).

    PubMed 

    Google Scholar
     

  • Németh, T., Sperandio, M. & Mócsai, A. Neutrophils as emerging therapeutic targets. Nat. Rev. Drug Discov. 19, 253–275 (2020).

    PubMed 

    Google Scholar
     

  • Pan American Health Organization. Dengue and Dengue Hemorrhagic Fever in the Americas: Guidelines for Prevention and Control Report No. 548 (PAHO, 1997).

  • Gordon, A. et al. The Nicaraguan pediatric influenza cohort study: design, methods, use of technology, and compliance. BMC Infect. Dis. 15, 504 (2015).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kuan, G. et al. The Nicaraguan Pediatric Dengue Cohort Study: study design, methods, use of information technology, and extension to other infectious diseases. Am. J. Epidemiol. 170, 120–129 (2009).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Narvaez, F. et al. Evaluation of the traditional and revised WHO classifications of dengue disease severity. PLoS Negl. Trop. Dis. 5, e1397 (2011).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Balmaseda, A. et al. Comparison of four serological methods and two reverse transcription-PCR assays for diagnosis and surveillance of Zika virus infection. J. Clin. Microbiol. 56, e01785-17 (2018).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Waggoner, J. J. et al. Single-reaction, multiplex, real-time RT-PCR for the detection, quantitation, and serotyping of dengue viruses. PLoS Negl. Trop. Dis. 7, e2116 (2013).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Waggoner, J. J. et al. Single-reaction multiplex reverse transcription PCR for detection of Zika, chikungunya, and dengue viruses. Emerg. Infect. Dis. 22, 1295–1297 (2016).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gordon, A. et al. Prior dengue virus infection and risk of Zika: a pediatric cohort in Nicaragua. PLoS Med. 16, e1002726 (2019).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cohen, J. Statistical Power Analysis for the Behavioral Sciences (Lawrence Erlbaum Associates, 2013).

  • Dias, A. G. et al. Anti-dengue virus antibodies that elicit complement-mediated lysis of Zika virion correlate with protection from severe dengue disease. Cell Rep. 44, 115613 (2025).

    PubMed 

    Google Scholar
     

  • Kudlacek, S. T. et al. Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies. Sci. Adv. 7, 4084–4099 (2021).


    Google Scholar
     

  • Cardona-Ospina, J. A. Antibody profiling and regularization model for pre-secondary DENV2 sera post-primary ZIKV infection—Pediatric Dengue Cohort Study. Zenodo https://doi.org/10.5281/zenodo.14837883 (2025).

  • Cardona-Ospina, J. A. Avidity index analysis and regularization model for pre-DENV2 sera post-primary ZIKV infection. Zenodo https://doi.org/10.5281/zenodo.14837889 (2025).

  • Cardona-Ospina, J. A. Post-Zika anti-NS1 serum IgA drives increased neutrophil functions in severe dengue disease. Zenodo https://doi.org/10.5281/zenodo.14837915 (2025).

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