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Factors influencing SARS-CoV-2 placental antibody transfer and neonatal transmission. A prospective, cohort study and review of available literature

  • Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Bio Med Atenei Parmensis. 2020;91:157–60.


    Google Scholar
     

  • COVID-19 Epidemiological Update. Edition 177. World Health Organization. 2025. https://www.who.int/publications/m/item/covid-19-epidemiological-update-edition-177. Accessed 1 Jun 2025.

  • Liu S, Zhong J, Zhang D. Transplacental transfer of maternal antibody against SARS-CoV-2 and its influencing factors: a review. Vaccines. 2022;10:1083.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • WHO Health Emergencies Programme. COVID-19 vaccination, World data. World Health Organization. 2025. https://data.who.int/dashboards/covid19/vaccines. Accessed 1 Jun 2025.

  • Male V. SARS-CoV-2 infection and COVID-19 vaccination in pregnancy. Nat Rev Immunol. 2022;22:277–82.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Candel-Pau J, Suqué-Tusell D, Maya-Enero S, Ramon-Iglesias C, Valle-del-Barrio B, López-Vílchez MÁ. Do timing and severity of gestational COVID-19 impact perinatal and neonatal outcomes? J Perinatol. 2025;45:1423–30.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Smith ER, Oakley E, Grandner GW, Rukundo G, Farooq F, Ferguson K, et al. Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis. Am J Obstet Gynecol. 2023;228:161–77.

    Article 
    PubMed 

    Google Scholar
     

  • Wastnedge EAN, Reynolds RM, Van Boeckel SR, Stock SJ, Denison FC, Maybin JA, et al. Pregnancy and COVID-19. Physiol Rev. 2021;101:303–18.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Grupo de Trabajo Técnico de Vacunación COVID-19, de la Ponencia de Programa y Registro de Vacunaciones. Estrategia de vacunación frente a COVID-19 en España. Actualización 8. Ministerio de Sanidad del Gobierno de España, 2021. https://www.sanidad.gob.es/areas/promocionPrevencion/vacunaciones/covid19/Actualizaciones_Estrategia_Vacunacion/docs/COVID-19_Actualizacion8_EstrategiaVacunacion.pdf. Accessed 1 Jun 2025.

  • Vercoutere A, Zina MJ, Telis M, Goffard J-C, Boulvain M, De Doncker L, et al. Seroprevalence and placental transfer of SARS-CoV-2 antibodies in unvaccinated pregnant women. BMC Infect Dis. 2024;24:509.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peng Z, Zhang J, Shi Y, Yi M. Research progress in vertical transmission of SARS-CoV-2 among infants born to mothers with COVID-19. Future Virol. 2022;17:211–4.

    Article 
    CAS 

    Google Scholar
     

  • Martinez-Portilla RJ. Vertical transmission of coronavirus disease 2019. Am J Obstet Gynecol. 2021;224:328–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kotlyar AM, Grechukhina O, Chen A, Popkhadze S, Grimshaw A, Tal O, et al. Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021;224:35–53. e3.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mourad M, Jacob T, Sadovsky E, Bejerano S, Simone GS-D, Bagalkot TR, et al. Placental response to maternal SARS-CoV-2 infection. Sci Rep. 2021;11:14390.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • On behalf of the Harvard Neonatal-Perinatal Fellowship COVID-19 Working Group, Barrero-Castillero A, Beam KS, Bernardini LB, Ramos EGC, Davenport PE, et al. COVID-19: neonatal–perinatal perspectives. J Perinatol. 2021;41:940–51.

    Article 

    Google Scholar
     

  • Maeda MDFY, Brizot MDL, Gibelli MABC, Ibidi SM, Carvalho WBD, Hoshida MS, et al. Vertical transmission of SARS-CoV2 during pregnancy: a high-risk cohort. Prenat Diagnosis. 2021;41:998–1008.

    Article 
    CAS 

    Google Scholar
     

  • Allotey J, Kew T, Fernández-García S, Gaetano-Gil A, Yap M, Sheikh J, et al. SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission: living systematic review and meta-analysis. BMJ. 2022;376:e067696.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lucot-Royer L, Nallet C, Vouga M, Puyraveau M, Mauny F, Marty-Quinternet S, et al. Analysis of the transplacental transmission of SARS CoV-2 virus and antibody transfer according to the gestational age at maternal infection. Sci Rep. 2024;14:3458.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Craina M, Iacob D, Dima M, Bernad S, Silaghi C, Moza A, et al. Clinical, laboratory, and imaging findings of pregnant women with possible vertical transmission of SARS-CoV-2—case series. IJERPH. 2022;19:10916.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Conti MG, Terreri S, Piano Mortari E, Albano C, Natale F, Boscarino G, et al. Immune response of neonates born to mothers infected with SARS-CoV-2. JAMA Netw Open. 2021;4:e2132563.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zerbo O, Ray GT, Fireman B, Layefsky E, Goddard K, Lewis E, et al. Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life. Nat Commun. 2023;14:894.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Poon LC, Leung BW, Ma T, Yu FNY, Kong CW, Lo TK, et al. Relationship between viral load, infection-to-delivery interval and mother-to-child transfer of anti-SARS-CoV -2 antibodies. Ultrasound Obstet Gyne. 2021;57:974–8.

    Article 
    CAS 

    Google Scholar
     

  • Capretti MG, Marsico C, Gabrielli L, Vocale C, Arcuri S, Simonazzi G, et al. Infants born following SARS-CoV-2 infection in pregnancy. Pediatrics. 2022;150:e2022056206.

    Article 
    PubMed 

    Google Scholar
     

  • Otero S, Miller ES, Sunderraj A, Shanes ED, Sakowicz A, Goldstein JA, et al. Maternal antibody response and transplacental transfer following severe acute respiratory syndrome Coronavirus 2 infection or vaccination in pregnancy. Clin Infect Dis. 2023;76:220–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Beharier O, Plitman Mayo R, Raz T, Nahum Sacks K, Schreiber L, Suissa-Cohen Y, et al. Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine. J Clin Investig. 2021;131:e150319.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nir O, Schwartz A, Toussia-Cohen S, Leibovitch L, Strauss T, Asraf K, et al. Maternal-neonatal transfer of SARS-CoV-2 immunoglobulin G antibodies among parturient women treated with BNT162b2 messenger RNA vaccine during pregnancy. Am J Obstet Gynecol MFM. 2022;4:100492.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rottenstreich A, Zarbiv G, Oiknine-Djian E, Vorontsov O, Zigron R, Kleinstern G, et al. Timing of SARS-CoV-2 vaccination during the third trimester of pregnancy and transplacental antibody transfer: a prospective cohort study. Clin Microbiol Infect. 2022;28:419–25.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Rottenstreich A, Zarbiv G, Oiknine-Djian E, Vorontsov O, Zigron R, Kleinstern G, et al. Kinetics of maternally derived anti–severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in infants in relation to the timing of antenatal vaccination. Clin Infect Dis. 2023;76:e274–e279.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zambrano H, Anchundia K, Aviles D, Andaluz R, Calderon N, Torres E, et al. Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region. Placenta. 2021;115:146–50.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Farahani M, Alirezaie B, Padyab M, Esna-Ashari F, Bahador D, Shahbazi R, et al. Transplacental transfer efficiency of SARS-CoV-2-specific IgG antibodies in iranian seropositive mothers: a monocentric study in Karaj, Iran. Arch Clin Infect Dis. 2023;18. https://doi.org/10.5812/archcid-139871.

  • Nielsen SY, Petersen LH, Murra M, Hvidman L, Helmig RB, Møller JK, et al. Transplacental transfer of SARS-CoV-2 antibodies: a cohort study. Eur J Clin Microbiol Infect Dis. 2023;42:277–85.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, et al. Assessment of maternal and neonatal cord blood SARS-CoV-2 antibodies and placental transfer ratios. JAMA Pediatr. 2021;175:594.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Enengl S, Pecks U, Oppelt P, Stelzl P, Trautner PS, Shebl O, et al. Antibody response and maternofetal antibody transfer in SARS-CoV-2-positive pregnant women: a multicenter observational study. Geburtshilfe Frauenheilkd. 2022;82:501–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cambou MC, Liu CM, Mok T, Fajardo-Martinez V, Paiola SG, Ibarrondo FJ, et al. Longitudinal evaluation of antibody persistence in mother-infant dyads after severe acute respiratory syndrome Coronavirus 2 infection in pregnancy. J Infect Dis. 2023;227:236–45.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sharmin E, Khan AI, Ahmed SF. Clinical assessment of transplacental transfer of maternal SARS-CoV-2 IgG antibodies against spike and nucleocapsid proteins: a chemiluminescence microparticle immunoassay study. PLoS One. 2025;20:e0336516.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Atyeo C, Pullen KM, Bordt EA, Fischinger S, Burke J, Michell A, et al. Compromised SARS-CoV-2-specific placental antibody transfer. Cell. 2021;184:628–42. e10.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sturrock S, Cavell B, Alexander F, Apostolakis K, Barro C, Daniel O, et al. Maternal and placental antibody responses in SARS-CoV-2 vaccination and natural infection during pregnancy. Pediatr Infect Dis J. 2025;44:S32–S37.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lopez PA, Nziza N, Chen T, Shook LL, Burns MD, Demidkin S, et al. Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants. iScience. 2024;27:109273.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mugo AG, Koech A, Cantrell L, Mukhanya M, Mwaniki I, Mutunga J, et al. Placental transfer of SARS-CoV-2 antibodies in mother-neonate pairs: a prospective nested cohort study. BMC Infect Dis. 2025;25. https://doi.org/10.1186/s12879-025-11225-6.

  • Shook LL, Atyeo CG, Yonker LM, Fasano A, Gray KJ, Alter G, et al. Durability of anti-spike antibodies in infants after maternal COVID-19 vaccination or natural infection. JAMA Netw Open. 2022;327:1087–108.

    CAS 

    Google Scholar
     

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