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Cognitive behavioral therapy for antiretroviral therapy adherence and treatment outcomes among people living with HIV: a systematic review and meta-analysis

  • Global Summary of the HIV/AIDS Epidemic 2020 (WHO, 2020); http://www.who.int/hiv/data/en/.

  • Panos, G. et al. Mortality and morbidity of HIV infected patients receiving HAART: a cohort study. Curr. HIV Res. 6, 257–260 (2008).

    Article 
    PubMed 

    Google Scholar
     

  • Cheung, C. C. et al. Reductions in all-cause and cause-specific mortality among HIV-infected individuals receiving antiretroviral therapy in British Columbia, Canada: 2001–2012. HIV Med. 17, 694–701 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mills, E. J. et al. Adherence to HAART: a systematic review of developed and developing nation patient-reported barriers and facilitators. PLoS Med. 3, e438 (2006).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ortego, C. et al. Adherence to highly active antiretroviral therapy (HAART): a meta-analysis. AIDS Behav. 15, 1381–1396 (2011).

    Article 
    PubMed 

    Google Scholar
     

  • O’Neil, C. R. et al. Factors associated with antiretroviral medication adherence among HIV-positive adults accessing highly active antiretroviral therapy (HAART) in British Columbia, Canada. J. Int. Assoc. Physicians AIDS Care 11, 134–141 (2012).

    Article 

    Google Scholar
     

  • Kim, J., Lee, E., Park, B.-J., Bang, J. H. & Lee, J. Y. Adherence to antiretroviral therapy and factors affecting low medication adherence among incident HIV-infected individuals during 2009–2016: a nationwide study. Sci. Rep. 8, 3133 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sethi, A. K., Celentano, D. D., Gange, S. J., Moore, R. D. & Gallant, J. E. Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance. Clin. Infect. Dis. 37, 1112–1118 (2003).

    Article 
    PubMed 

    Google Scholar
     

  • Haguihara, T. et al. Factors associated with mortality in HIV patients failing antiretroviral therapy, in Salvador, Brazil. Braz. J. Infect. Dis. 23, 160–163 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lenzi, L., Wiens, A. & Pontarolo, R. Evaluation of adverse events associated with antiretroviral therapy and the relationship to treatment adherence. Int. J. Clin. Pharmacol. Ther. 51, 141–146 (2013).

    Article 
    PubMed 

    Google Scholar
     

  • Zhang, L. et al. Side effects, adherence self-efficacy, and adherence to antiretroviral treatment (ART): a mediation analysis in a Chinese sample. AIDS Care 28, 919–926 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Minwagaw, M. T., Akenie, B. B., Tewabe, D. S., Tegegne, A. S. & Beyene, T. B. Predictors of poor adherence to CART and treatment failure at second-line regimens among adults in public hospitals of Amhara Region, north-western Ethiopia: a retrospective cohort study. Patient Prefer. Adherence 15, 2855–2864 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Starace, F. et al. Depression Is a risk factor for suboptimal adherence to highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 31, S136–S139 (2002).

    Article 
    PubMed 

    Google Scholar
     

  • Socías, M. E. & Milloy, M.-J. Substance use and adherence to antiretroviral therapy: what is known, and what is unknown. Curr. Infect. Dis. Rep. 20, 36 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bukenya, D., Mayanja, B. N., Nakamanya, S., Muhumuza, R. & Seeley, J. What causes non-adherence among some individuals on long term antiretroviral therapy? Experiences of individuals with poor viral suppression in Uganda. AIDS Res. Ther. 16, 2 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Adeniran, A., Odugbemi, B. A., Fisher, O. O. & Atilola, O. Determinants of adherence among patients on highly active anti-retroviral therapy in Lagos State, Nigeria. West Afr. J. Med. 38, 520–525 (2021).

    PubMed 

    Google Scholar
     

  • Easthall, C., Song, F. & Bhattacharya, D. A meta-analysis of cognitive-based behaviour change techniques as interventions to improve medication adherence. BMJ Open 3, e002749 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wenzel, A. Basic strategies of cognitive behavioral therapy. Psychiatr. Clin. North Am. 40, 597–609 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • Safren, S. A. et al. A randomized controlled trial of cognitive behavioral therapy for adherence and depression (CBT-AD) in patients with uncontrolled type 2 diabetes. Diabetes Care 37, 625–633 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Szentagotai, A. & David, D. The efficacy of cognitive–behavioral therapy in bipolar disorder: a quantitative meta-analysis. J. Clin. Psychiatry 71, 66–72 (2010).

    Article 
    PubMed 

    Google Scholar
     

  • Abbas, Q. et al. Brief cognitive behavior therapy for stigmatization, depression, quality of life, social support and adherence to treatment among patients with HIV/AIDS: a randomized control trial. BMC Psychiatry 23, 539 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Junkins, A. et al. Feasibility, acceptability, and preliminary impact of telemedicine-administered cognitive behavioral therapy for adherence and depression among African American women living with HIV in the rural South. J. Health Psychol. 26, 2730–2742 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Lamb, K. M., Nogg, K. A., Safren, S. A. & Blashill, A. J. Mechanism of change in cognitive behavioral therapy for body image and self-care on ART adherence among sexual minority men living with HIV. AIDS Behav. 22, 2711–2717 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Madhombiro, M. et al. Psychological interventions for alcohol use disorders in people living with HIV/AIDS: a systematic review. Syst. Rev. 8, 244 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Knight, L., Mukumbang, F. C. & Schatz, E. Behavioral and cognitive interventions to improve treatment adherence and access to HIV care among older adults in sub-Saharan Africa: an updated systematic review. Syst. Rev. 7, 114 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kanters, S. et al. Interventions to improve adherence to antiretroviral therapy: a systematic review and network meta-analysis. Lancet HIV 4, e31–e40 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • Bhatta, D. N., Liabsuetrakul, T. & McNeil, E. B. Social and behavioral interventions for improving quality of life of HIV infected people receiving antiretroviral therapy: a systematic review and meta-analysis. Health Qual. Life Outcomes 15, 80 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yu, Y. et al. The benefits of psychosocial interventions for mental health in men who have sex with men living with HIV: a systematic review and meta-analysis. BMC Psychiatry 22, 440 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Asrat, B., Schneider, M., Ambaw, F. & Lund, C. Effectiveness of psychological treatments for depressive symptoms among people living with HIV/AIDS in low- and middle-income countries: a systematic review and meta-analysis. J. Affect. Disord. 270, 174–187 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Scott-Sheldon, L. A. J. et al. Mindfulness-based interventions for adults living with HIV/AIDS: a systematic review and meta-analysis. AIDS Behav. 23, 60–75 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shi, Y. et al. Effects of cognitive behavioral therapy on people living with HIV and depression: a systematic review and meta-analysis. Psychol. Health Med. 24, 578–594 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Qin, K., Zeng, J., Liu, L. & Cai, Y. Effects of cognitive behavioral therapy on improving depressive symptoms and increasing adherence to antiretroviral medication in people with HIV. Front. Psychiatry 13, 990994 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Antoni, M. H. et al. Randomized clinical trial of cognitive behavioral stress management on human immunodeficiency virus viral load in gay men treated with highly active antiretroviral therapy. Psychosom. Med. 68, 143–151 (2006).

    Article 
    PubMed 

    Google Scholar
     

  • Blashill, A. J. et al. Cognitive behavioral therapy for body image and self-care (CBT-BISC) in sexual minority men living with HIV: a randomized controlled trial. Health Psychol. 36, 937–946 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bogart, L. M. et al. Pilot randomized controlled trial of an intervention to improve coping with intersectional stigma and medication adherence among HIV-positive Latinx sexual minority men. AIDS Behav. 25, 1647–1660 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Brown, L. K. et al. Effective treatment of depressive disorders in medical clinics for adolescents and young adults living with HIV: a controlled trial. J. Acquir. Immune Defic. Syndr. 71, 38–46 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Carrico, A. W. et al. Reductions in depressed mood and denial coping during cognitive behavioral stress management with HIV-positive gay men treated with HAART. Ann. Behav. Med. 31, 155–164 (2006).

    Article 
    PubMed 

    Google Scholar
     

  • Chattopadhyay, S. et al. Cognitive behavioral therapy improves adherence to antiretroviral therapy in HIV-infected patients: a prospective randomized controlled trial from eastern India. HIV AIDS Rev. 16, 89–95 (2017).

    Article 

    Google Scholar
     

  • Dow, D. E. et al. A group-based mental health intervention for young people living with HIV in Tanzania: results of a pilot individually randomized group treatment trial. BMC Public Health 20, 1358 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Goggin, K. et al. A randomized controlled trial examining the efficacy of motivational counseling with observed therapy for antiretroviral therapy adherence. AIDS Behav. 17, 1992–2001 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gonzalez-Garcia, M. et al. Effectiveness of mindfulness-based cognitive therapy on the quality of life, emotional status, and CD4 cell count of patients aging with HIV infection. AIDS Behav. 18, 676–685 (2014).

    Article 
    PubMed 

    Google Scholar
     

  • Magidson, J. F. et al. Project Khanya: results from a pilot randomized type 1 hybrid effectiveness-implementation trial of a peer-delivered behavioural intervention for ART adherence and substance use in HIV care in South Africa. J. Int. AIDS Soc. 24, e25720 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Murphy, D. A., Lu, M. C., Martin, D., Hoffman, D. & Marelich, W. D. Results of a pilot intervention trial to improve antiretroviral adherence among HIV-positive patients. J. Assoc. Nurses AIDS Care. 13, 57–69 (2002).

    Article 
    PubMed 

    Google Scholar
     

  • Parsons, J. T., John, S. A., Millar, B. M. & Starks, T. J. Testing the efficacy of combined motivational interviewing and cognitive behavioral skills training to reduce methamphetamine use and improve HIV medication adherence among HIV-positive gay and bisexual men. AIDS Behav. 22, 2674–2686 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Psaros, C. et al. Optimizing PMTCT adherence by treating depression in perinatal women with HIV in South Africa: a pilot randomized controlled trial. Int. J. Behav. Med. 30, 62–76 (2023).

    Article 
    PubMed 

    Google Scholar
     

  • Safren, S. A. et al. Cognitive behavioral therapy for adherence and depression (CBT-AD) in HIV-infected injection drug users: a randomized controlled trial. J. Consult. Clin. Psychol. 80, 404–415 (2012).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Safren, S. A. et al. Cognitive behavioural therapy for adherence and depression in patients with HIV: a three-arm randomised controlled trial. Lancet HIV 3, e529–e538 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Safren, S. A. et al. Treating depression and improving adherence in HIV care with task-shared cognitive behavioural therapy in Khayelitsha, South Africa: a randomized controlled trial. J. Int. AIDS Soc. 24, e25823 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Simoni, J. M. et al. A preliminary RCT of CBT-AD for adherence and depression among HIV-positive Latinos on the US–Mexico border: the Nuevo Día study. AIDS Behav. 17, 2816–2829 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Katz, I. T. et al. Impact of HIV-related stigma on treatment adherence: systematic review and meta-synthesis. J. Int. AIDS Soc. 16, 18640 (2013).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mate, K. K. V., Engler, K., Lessard, D. & Lebouché, B. Barriers to adherence to antiretroviral therapy: identifying priority areas for people with HIV and healthcare professionals. Int. J. STD AIDS 34, 677–686 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Menza, T. W., Hixson, L. K., Lipira, L. & Drach, L. Social determinants of health and care outcomes among people with HIV in the United States. Open Forum Infect. Dis. 8, ofab330 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mukherjee, J. S., Barry, D., Weatherford, R. D., Desai, I. K. & Farmer, P. E. Community-based ART programs: sustaining adherence and follow-up. Curr. HIV/AIDS Rep. 13, 359–366 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Necho, M., Zenebe, Y., Tiruneh, C., Ayano, G. & Yimam, B. The global landscape of the burden of depressive symptoms/major depression in individuals living with HIV/AIDs and its effect on antiretroviral medication adherence: an umbrella review. Front. Psychiatry 13, 814360 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Uthman, O. A., Magidson, J. F., Safren, S. A. & Nachega, J. B. Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: a systematic review and meta-analysis. Curr. HIV/AIDS Rep. 11, 291–307 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Velloza, J. et al. Alcohol use and antiretroviral therapy non-adherence among adults living with HIV/AIDS in sub-Saharan Africa: a systematic review and meta-analysis. AIDS Behav. 24, 1727–1742 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mendez-Lopez, A., White, T. M., Fuster-RuizdeApodaca, M. J. & Lazarus, J. V. Prevalence and sociodemographic determinants of public stigma towards people with HIV and its impact on HIV testing uptake: a cross-sectional study in 64 low- and middle-income countries. HIV Med. 25, 83–94 (2024).

    Article 
    PubMed 

    Google Scholar
     

  • Gesesew, H. A. et al. Significant association between perceived HIV related stigma and late presentation for HIV/AIDS care in low and middle-income countries: A systematic review and meta-analysis. PLoS ONE 12, e0173928 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rueda, S. et al. Examining the associations between HIV-related stigma and health outcomes in people living with HIV/AIDS: a series of meta-analyses. BMJ Open 6, e011453 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Buh, A. et al. Barriers and facilitators for interventions to improve ART adherence in sub-Saharan African countries: a systematic review and meta-analysis. PLoS ONE 18, e0295046 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Karyotaki, E. et al. Association of task-shared psychological interventions with depression outcomes in low- and middle-income countries. JAMA Psychiatry 79, 430–443 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Le, P. D. et al. Barriers and facilitators to implementation of evidence-based task-sharing mental health interventions in low- and middle-income countries: a systematic review using implementation science frameworks. Implement. Sci. 17, 4 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Flückiger, C. & Del Re, A. C. The sleeper effect between psychotherapy orientations: a strategic argument of sustainability of treatment effects at follow-up. Epidemiol. Psychiatr. Sci. 26, 442–444 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Carroll, K. M. et al. One-year follow-up of psychotherapy and pharmacotherapy for cocaine dependence. Delayed emergence of psychotherapy effects. Arch. Gen. Psychiatry 51, 989–997 (1994).

    Article 
    PubMed 

    Google Scholar
     

  • Erjino, E., Abera, E. & Lemma Tirore, L. Time to viral load suppression and its predictors among adult patients on antiretro viral therapy in Nigist Eleni Mohammed Memorial Comprehensive Specialized Hospital, Hossana, southern Ethiopia. HIV AIDS 15, 157–171 (2023).


    Google Scholar
     

  • Kousignian, I. et al. Modeling the time course of CD4 T-lymphocyte counts according to the level of virologic rebound in HIV-1-infected patients on highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 34, 50–57 (2003).

    Article 
    PubMed 

    Google Scholar
     

  • Zhao, A. V. et al. A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection. Retrovirology 19, 22 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Simoni, J. M. et al. Self-report measures of antiretroviral therapy adherence: a review with recommendations for HIV research and clinical management. AIDS Behav. 10, 227–245 (2006).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Naqvi, A. A. et al. Development and validation of a novel general medication adherence scale (GMAS) for chronic illness patients in Pakistan. Front. Pharmacol. 9, 1124 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chesney, M. A. et al. Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient Care Committee & Adherence Working Group of the Outcomes Committee of the Adult AIDS Clinical Trials Group (AACTG). AIDS Care 12, 255–266 (2000).

    Article 
    PubMed 

    Google Scholar
     

  • Bova, C. A. et al. Use of electronic monitoring devices to measure antiretroviral adherence: practical considerations. AIDS Behav. 9, 103–110 (2005).

    Article 
    PubMed 

    Google Scholar
     

  • Pearson, C. R., Simoni, J. M., Hoff, P., Kurth, A. E. & Martin, D. P. Assessing antiretroviral adherence via electronic drug monitoring and self-report: an examination of key methodological issues. AIDS Behav. 11, 161–173 (2007).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Pellowski, J. A. et al. Real-time medication adherence monitoring intervention: test of concept in people living with HIV infection. J. Assoc. Nurses AIDS Care 25, 646–651 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Covidence (Veritas Health Innovation, 2024); www.covidence.org

  • Higgins, J. et al. Cochrane Handbook for Systematic Reviews of Interventions (John Wiley & Sons, 2019); https://doi.org/10.1002/9781119536604

  • Lakens, D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front. Psychol. https://doi.org/10.3389/fpsyg.2013.00863 (2013).

  • Egger, M., Davey Smith, G., Schneider, M. & Minder, C. Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629–634 (1997).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stata Statistical Software: Release 18 (StataCorp, 2023).

  • Page, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372, n71 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Source link

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