Bill Hader and Ali Wong have called it quits after more than 2 years together … TMZ has confirmed.

The 2 comedians have gone their separate ways, a source tells us … citing their busy schedules as a major reason for their breakup.

We’re told they are both focused on their careers and families right now, rather than their love lives. People broke the news of the split.

Hader and Wong sparked split speculation when he did not attend the Globes to support Wong in January last year, and she did not mention him in her speech after she won.