Competing interests

The authors report the following conflicts of interest: Dr. Hamilton reports (ad hoc) advisory boards for Sanofi, Incyte, Maat; research funding from Incyte; adjudication committee with CSL Behring. The remaining authors have no relevant disclosures to report.

Ethics approval and consent to participate

This study was approved by the Cleveland Clinic Institutional Review Board, which deemed this study minimal risk research not requiring informed consent. All methods were performed in compliance with the relevant regulations, including the Declaration of Helsinki. No identifiable patient details are presented in this manuscript.