Stock Ticker

405 nm light microbicidal efficacy on Treponema pallidum spiked in ex vivo human platelets

  • Arora, N. et al. Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. Nat. Microbiol. 2, 16245 (2016).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Giacani, L. & Lukehart, S. A. The endemic treponematoses. Clin. Microbiol. Rev. 27, 89–115 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peeling, R. W. et al. Syphilis. Nat. Rev. Dis. Primers 3, 17073 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lafond, R. E. & Lukehart, S. A. Biological basis for syphilis. Clin. Microbiol. Rev. 19, 29–49 (2006).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Center for Disease Control and Prevention. Sexually Transmitted Disease Surveillance, 2022. Available from: https://www.cdc.gov/std/statistics/2022/overview.htm#Syphilis.

  • Chambers, R. W., Foley, H. T. & Schmidt, P. J. Transmission of syphilis by fresh blood components. Transfusion 9, 32–34 (1969).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Conti, G. et al. US Transfusion-Transmissible Infections Monitoring System (TTIMS). Syphilis seroprevalence and incidence in US blood donors from 2020 to 2022. Transfusion 64, 325–333 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O’Brien, S. F. et al. Monitoring syphilis serology in blood donors: Is there utility as a surrogate marker of early transfusion transmissible infection behavioral risk?. Transfusion 63, 1195–1203 (2023).

    Article 
    PubMed 

    Google Scholar
     

  • UK Health Security Agency and NHS Blood and Transplant. Safe supplies 2021: FAIRer donor selection. Accessed April 15, 2024. Available from: https://nhsbtdbe.blob.core.windows.net/umbraco-assets-corp/27793/annual-review-with-a4-infographics-final-accessible-features-v3.pdf

  • Guidance for Industry: Recommendations for Screening, Testing and Management of Blood Donors and Blood and Blood Components Based on Screening Tests for Syphilis. December 2020. Available from: https://www.fda.gov/media/85283/download

  • Tamrakar, P. et al. Effect of storage on survival of infectious Treponema pallidum spiked in whole blood and platelets. Transfusion 61, 3181–3189 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • D’aes, T. et al. Does cold storage of blood before transfusion prevent the transmission of syphilis? A systematic review and meta-analysis. Vox Sang. 119, 219–231 (2024).

    Article 
    PubMed 

    Google Scholar
     

  • Klein, H. G., Hrouda, J. C. & Epstein, J. S. Crisis in the sustainability of the U.S. blood system. N. Engl. J. Med. 377, 1485–1488 (2017).

    Article 
    PubMed 

    Google Scholar
     

  • Schiffer, C. A. et al. Platelet transfusion for patients with cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J. Clin. Oncol. 36, 283–299 (2018).

    Article 
    PubMed 

    Google Scholar
     

  • Lee, R. H., Kasthuri, R. S. & Bergmeier, W. Platelet transfusion for patients with platelets dysfunction: Effectiveness, mechanisms, and unanswered questions. Curr. Opin. Hematol. 27, 378–385 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • White, S. K., Schmidt, R. L., Walker, B. S. & Metcalf, R. A. Bacterial contamination rate of platelet components by primary culture: A systematic review and meta-analysis. Transfusion 60, 986–996 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kracalik, I. et al. Posttransfusion sepsis attributable to bacterial contamination in platelet collection set manufacturing facility, United States. Emerg. Infect Dis. 29, 1979–1989 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schmidt, M., Ramirez-Arcos, S., Stiller, L. & McDonald, C. ISBT Transfusion-Transmitted Infectious Diseases Working Party, Subgroup on Bacteria. Current status of rapid bacterial detection methods for platelet components: A 20-year review by the ISBT Transfusion-Transmitted Infectious Diseases Working Party Subgroup on Bacteria. Vox Sang. 117, 983–988 (2022).

  • Kamel, H., Ramirez-Arcos, S. & McDonald, C. ISBT Transfusion-Transmitted Infectious Disease Bacterial Working Party Bacterial Subgroup. The international experience of bacterial screen testing of platelet components with automated microbial detection systems: An update. Vox Sang. 117, 647–655 (2022).

  • Störmer, M. & Vollmer, T. Diagnostic methods for platelet bacteria screening: current status and developments. Transfus. Med. Hemother. 41, 19–27 (2014).

    Article 
    PubMed 

    Google Scholar
     

  • Levy, J. H., Neal, M. D. & Herman, J. H. Bacterial contamination of platelets for transfusion: Strategies for prevention. Crit. Care 22, 271 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cloutier, M. & De Korte, D. ISBT Transfusion-Transmitted Infectious Diseases Working Party, Subgroup on Bacteria. Residual risks of bacterial contamination for pathogen-reduced platelet components. Vox Sang. 117, 879–886 (2022).

    Article 
    PubMed 

    Google Scholar
     

  • Lanteri, M. C. et al. Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light. Transfusion 60, 1319–1331 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin, L. et al. Photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria. Transfusion 44, 1496–1504 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Singh, Y. et al. Photochemical treatment of plasma with amotosalen and long-wavelength ultraviolet light inactivates pathogens while retaining coagulation function. Transfusion 46, 1168–1177 (2006).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Goodrich, R. P., Gilmour, D., Hovenga, N. & Keil, S. D. A laboratory comparison of pathogen reduction technology treatment and culture of platelet products for addressing bacterial contamination concerns. Transfusion 49, 1205–1216 (2009).

    Article 
    PubMed 

    Google Scholar
     

  • Kwon, S. Y. et al. Pathogen inactivation efficacy of Mirasol PRT System and Intercept Blood System for non-leucoreduced platelet-rich plasma-derived platelets suspended in plasma. Vox Sang. 107, 254–260 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gravemann, U., Handke, W., Müller, T. H. & Seltsam, A. Bacterial inactivation of platelet concentrates with the THERAFLEX UV-Platelets pathogen inactivation. Transfusion 59, 1324–1332 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Marks, P. & Verdun, N. Toward universal pathogen reduction of the blood supply (Conference Report, p. 3002). Transfusion 59, 3026–3028 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Brixner, V. et al. Red blood cells treated with the amustaline (S-303) pathogen reduction system: A transfusion study in cardiac surgery. Transfusion 58, 905–916 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Atreya, C., Maclean, M., Anderson, J. G. & MacGregor, S. J. (2024). Inactivation of pathogens in ex vivo blood products in storage bags using visible light. (Patent No. US Patent 11,951,217).

  • Maclean, M. et al. Non-ionizing 405 nm light as a potential bactericidal technology for platelet safety: Evaluation of in vitro bacterial inactivation and in vivo platelet recovery in severe combined immunodeficient mice. Front Med. (Lausanne). 6, 331 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sun, J. et al. Metabolomics evaluation of the photochemical impact of violet blue light (405 nm) on ex vivo platelet concentrates. Metabolomics 19, 88 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stewart, C. F. et al. Violet-blue 405-nm Light-based photoinactivation for pathogen reduction of human plasma provides broad antibacterial efficacy without visible degradation of plasma proteins. Photochem. Photobiol. 98, 504–512 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kaldhone, P. R. et al. The preclinical validation of 405 nm light parasiticidal efficacy on Leishmania donovani in ex vivo platelets in a Rag2(-/-) mouse model. Microorganisms 12, 280 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Haridas, D. & Atreya, C. D. The microbicidal potential of visible blue light in clinical medicine and public health. Front. Med. Lausanne 9, 905606 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Maclean, M., MacGregor, S. J., Anderson, J. G. & Woolsey, G. Inactivation of bacterial pathogens following exposure to light from a 405-nanometer light-emitting diode array. Appl. Environ. Microbiol. 75, 1932–1937 (2009).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jankowska, K. I. et al. Complete inactivation of blood borne pathogen Trypanosoma cruzi in stored human platelet concentrates and plasma treated with 405 nm violet-blue light. Front Med. (Lausanne) 7, 617373 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Ragupathy, V. et al. Visible 405 nm violet-blue light successfully inactivates HIV-1 in human plasma. Pathogens 11, 778 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jackson, J. W. et al. 405 nm violet-blue light inactivates hepatitis C cell culture virus (HCVcc) in ex vivo human platelet concentrates and plasma. Sci. Rep. 14, 31540 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wicher, K. et al. Identification of persistent infection in experimental syphilis by PCR. Infect. Immun. 66, 2509–2513 (1998).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Turner, T. B. & Hollander, D. H. Biology of the treponematoses. Monogr. Ser. World Health Organ. 35, 3–266 (1957).


    Google Scholar
     

  • Gao, K. et al. Origin of nontreponemal antibodies during Treponema pallidum infection: Evidence from a rabbit model. J. Infect. Dis. 218, 835–843 (2018).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Jackson, J. W. et al. Human platelet concentrates treated with microbicidal 405 nm light retain hemostasis activity. J. Photochem. Photobiol. B 255, 112922 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stewart, C. F. et al. Microbial reduction of prebagged human plasma using 405 nm light and its effects on coagulation factors. AMB Express 14, 66 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Edmondson, D. G., Hu, B. & Norris, S. J. Long-term in vitro culture of the Syphilis Spirochete Treponema pallidum subsp. pallidum. MBio 9, e01153-e1218 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fieldsteel, A. H., Cox, D. L. & Moeckli, R. A. Cultivation of virulent Treponema pallidum in tissue culture. Infect Immun. 32, 908–915 (1981).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • McDonald, C. P., Bearne, J., Aplin, K. & Sawicka, D. Assessing the inactivation capabilities of two commercially available platelet component pathogen inactivation systems: effectiveness at end of shelf life. Vox Sang. 116, 416–424 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Maclean, M., Anderson, J. G., MacGregor, S. J., White, T. & Atreya, C. D. A New proof of concept in bacterial reduction: Antimicrobial action of violet-blue light (405 nm) in ex vivo stored plasma. J. Blood Transfus. 2016, 2920514 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lukehart, S. A. & Marra, C. M. Isolation and laboratory maintenance of Treponema pallidum. Curr. Protoc. Microbiol. Chapter 12: Unit 12A.1 (2007).

  • Wang, C. et al. Sensitive detection of Treponema pallidum DNA from the whole blood of patients with syphilis by the nested PCR assay. Emerg. Microbes Infect. 7, 83 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Reed, L. J. & Muench, H. A simple method of estimating fifty per cent endpoints. Am. J. Epidemiol. 27, 493–497 (1938).

    Article 

    Google Scholar
     

  • Source link

    Get RawNews Daily

    Stay informed with our RawNews daily newsletter email

    Liverpool defender left out of World Cup squad

    Madonna Covering Rent For Musicians Working At Her Old NYC Rehearsal Space

    Up 16.5%! Here’s why Hollywood Bowl stock smashed the FTSE 250 today

    Trump says Iran would not get sanctions relief in exchange for giving up enriched uranium