Travassos da Rosa, J. F. et al. Oropouche virus: clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus. Am. J. Trop. Med. Hyg. 96, 1019–1030 (2017).
de Souza, W. M. et al. ICTV virus taxonomy profile: Peribunyaviridae 2024. J. Gen. Virol. 105, 002034 (2024).
das Neves Martins, F. E. et al. Newborns with microcephaly in Brazil and potential vertical transmission of Oropouche virus: a case series. Lancet Infect. Dis. 25, 155–165 (2024).
Bandeira, A. C. et al. Fatal Oropouche virus infections in nonendemic region, Brazil, 2024. Emerg. Infect. Dis. 30, 2370–2374 (2024).
de Lima, S. T. S. et al. Molecular epidemiology of Oropouche virus, Ceará State, Brazil, 2024. Emerg. Infect. Dis. 31, 838–842 (2025).
Scachetti, G. C. et al. Re-emergence of Oropouche virus between 2023 and 2024 in Brazil: an observational epidemiological study. Lancet Infect. Dis. 25, 166–175 (2024).
Naveca, F. G. et al. Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region. Nat. Med. 30, 3509–3521 (2024).
Srivastava, S. et al. The emergence of Oropouche fever: a potential new threat? New Microbes New Infect. 65, 101596 (2025).
Capobianchi, M. R., Castilletti, C. & Gobbi, F. G. Potential risks of Oropouche virus importation into Europe. J. Travel Med. 31, taae109 (2024).
Morrison, A. et al. Oropouche virus disease among U.S. travelers – United States, 2024. MMWR Morb. Mortal Wkly Rep. 73, 769–773 (2024).
Gräf, T. et al. Expansion of Oropouche virus in non-endemic Brazilian regions: analysis of genomic characterisation and ecological drivers. Lancet Infect. Dis. 25, 379–389 (2024).
Lim, A. et al. The overlapping global distribution of dengue, chikungunya, Zika and yellow fever. Nat. Commun. 16, 3418 (2025).
Feitoza, L. H. M. et al. Influence of meteorological and seasonal parameters on the activity of Culicoides paraensis (Diptera: Ceratopogonidae), an annoying anthropophilic biting midge and putative vector of Oropouche virus in Rondônia, Brazilian Amazon. Acta Trop. 243, 106928 (2023).
McGregor, B. L., Connelly, C. R. & Kenney, J. L. Infection, dissemination, and transmission potential of North American Culex quinquefasciatus, Culex tarsalis, and Culicoides sonorensis for Oropouche virus. Viruses 13, 226 (2021).
Mellor, P. S., Boorman, J. & Baylis, M. Culicoides biting midges: their role as arbovirus vectors. Annu. Rev. Entomol. 45, 307–340 (2000).
Payne, A. F. et al. Lack of competence of US mosquito species for circulating Oropouche virus. Emerg. Infect. Dis. 31, 619–621 (2024).
de Mendonça, S. F. et al. Evaluation of Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus mosquitoes Competence to Oropouche virus infection. Viruses 13, 755 (2021).
Erram, D., Blosser, E. M. & Burkett-Cadena, N. Habitat associations of Culicoides species (Diptera: Ceratopogonidae) abundant on a commercial cervid farm in Florida, USA. Parasit. Vectors 12, 367 (2019).
Delatorre, E. et al. Emergence of Oropouche virus in Espírito Santo state, Brazil, 2024. Emerg. Infect. Dis. 31, 1178–1188 (2025).
Tegally, H. et al. Dynamics and ecology of a multi-stage expansion of Oropouche virus in Brazil. Preprint at medRxiv https://doi.org/10.1101/2024.10.29.24316328 (2024).
2022 Census: 87% of the Brazilian population lives in urban areas (Instituto Brasileiro de Geografia e Estatística, 2024). https://agenciadenoticias.ibge.gov.br/en/agencia-news/2184-news-agency/news/41910-2022-census-87-of-the-brazilian-population-lives-in-urban-areas
de Souza, W. M. & Weaver, S. C. Effects of climate change and human activities on vector-borne diseases. Nat. Rev. Microbiol. 22, 476–491 (2024).
Instituto Brasileiro de Geografia e Estatística. Population Census 2010 https://www.ibge.gov.br/en/statistics/multi-domain/culture-recreation-and-sports/18391-2010-population-census.html (2010).
Cori, A., Ferguson, N. M., Fraser, C. & Cauchemez, S. A new framework and software to estimate time-varying reproduction numbers during epidemics. Am. J. Epidemiol. 178, 1505–1512 (2013).
Delatorre, E. et al. Emergence of Oropouche virus in Espirito Santo state, Brazil, 2024. Emerg. Infect. Dis. 31, 1178–1188 (2025).
Shao, Y., Magee, A. F., Vasylyeva, T. I. & Suchard, M. A. Scalable gradients enable Hamiltonian Monte Carlo sampling for phylodynamic inference under episodic birth-death-sampling models. PLoS Comput. Biol. 20, e1011640 (2024).
Stadler, T., Kuhnert, D., Bonhoeffer, S. & Drummond, A. J. Birth-death skyline plot reveals temporal changes of epidemic spread in HIV and hepatitis C virus (HCV). Proc. Natl Acad. Sci. USA 110, 228–233 (2013).
Ferreira, M. A. R. & Suchard, M. A. Bayesian analysis of elapsed times in continuous-time Markov chains. Can. J. Stat. 36, 355–368 (2008).
Suchard, M. A. et al. Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10. Virus. Evol. 4, vey016 (2018).
Breiman, L. Random forests. Mach. Learn. 45, 5–32 (2001).
McCullagh, P. & Nelder, J. A. Generalized Linear Model (Routledge, 2018).
Cushman, S. A. & Wasserman, T. N. in Machine Learning for Ecology and Sustainable Natural Resource Management (eds Humphries, G. et al.) 185–203 (Springer International, 2018).
Kamvar, Z. N., Cai, J., Pulliam, J. R. C., Schumacher, J. & Jombart, T. Epidemic curves made easy using the R package incidence. F1000Res 8, 139 (2019).
Instituto Brasileiro de Geografia e Estatística (IBGE, 2025). https://www.ibge.gov.br/estatisticas/sociais/trabalho/22827-censo-demografico-2022.html
Population Census 2022 (Instituto Brasileiro de Geografia e Estatística, 2022).
Baston, D. Exactextractr: Fast Extraction from Raster Datasets Using Polygons. R package version 0.10.1 (2025).
Pereira, R. H. M. & Goncalves, C. N. geobr: Download Official Spatial Data Sets of Brazil https://cran.r-project.org/web/packages/geobr/index.html (2025).
Poppiel, R. R. et al. Soil health in Latin America and the Caribbean. Commun. Earth Environ. 6, 141 (2025).
Ishwaran, H. & Kogalur, U. B. Fast Unified Random Forests with randomForestSRrandomForestSRC: Fast Unified Random Forests for Survival, Regression, and Classification (RF-SRC). R package version 3.5.0 (2025).
R Core Team and contributors worldwide The R Stats Package version 4.4.2. Vol. 2025 (2019).
Fick, S. E. & Hijmans, R. J. WorldClim 2: new 1-km spatial resolution climate surfaces for global land areas. Int. J. Climatol. 37, 4302–4315 (2017).
Agrometeorological Indicators from 1979 up to 2019 Derived from Reanalysis. Copernicus Climate Change Service https://cds.climate.copernicus.eu/datasets/sis-agrometeorological-indicators?tab=overview (2025).
