Mostowy S, Shenoy AR. The cytoskeleton in cell-autonomous immunity: structural determinants of host defence. Nat Rev Immunol. 2015;15:559–73.
Joo E, Olson MF. Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1. Small GTPases. 2021;12:358–71.
Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, et al. GEF-H1 signaling upon microtubule destabilization is required for dendritic cell activation and specific anti-tumor responses. Cell Rep. 2019;28:3367–80 e8.
Chiang HS, Zhao Y, Song JH, Liu S, Wang N, Terhorst C, et al. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol. 2014;15:63–71.
Zhang X, Wu J, Liu Q, Li X, Li S, Chen J, et al. mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion. Cell Death Dis. 2020;11:1050.
Rucker AJ, Park CS, Li QJ, Moseman EA, Chan FK. Necroptosis stimulates interferon-mediated protective anti-tumor immunity. Cell Death Dis. 2024;15:403.
Zhang X, Wu J, Liu Q, Li X, Yang Y, Wu L, et al. RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis. Clin Transl Med. 2023;13:e1334.
Basavaraju S, Mishra S, Jindal R, Kesavardhana S. Emerging role of ZBP1 in Z-RNA sensing, influenza virus-induced cell death, and pulmonary inflammation. mBio. 2022;13:e0040122.
Galluzzi L, Kepp O, Chan FK, Kroemer G. Necroptosis: mechanisms and relevance to disease. Annu Rev Pathol. 2017;12:103–30.
Xie F, Wu D, Huang J, Liu X, Shen Y, Huang J, et al. ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction. Cell Death Dis. 2024;15:487.
Malhotra J, Chiappori A, Fujioka N, Hanna NH, Feldman LE, Patel M, et al. Phase I/II trial of plinabulin in combination with nivolumab and ipilimumab in patients with recurrent small cell lung cancer (SCLC): Big ten cancer research consortium (BTCRC-LUN17-127) study. Lung Cancer. 2024;195:107932.
Birkenfeld J, Nalbant P, Yoon SH, Bokoch GM. Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis? Trends Cell Biol. 2008;18:210–9.
Kuriakose T, Kanneganti TD. ZBP1: innate sensor regulating cell death and inflammation. Trends Immunol. 2018;39:123–34.
Imai T, Lin J, Kaya GG, Ju E, Kondylis V, Kelepouras K, et al. The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity. 2024;57:1497–513.e6.
Lai K, Wang J, Lin S, Chen Z, Lin G, Ye K, et al. Sensing of mitochondrial DNA by ZBP1 promotes RIPK3-mediated necroptosis and ferroptosis in response to diquat poisoning. Cell Death Differ. 2024;31:635–50.
Koerner L, Wachsmuth L, Kumari S, Schwarzer R, Wagner T, Jiao H, et al. ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell Death Differ. 2024;31:938–53.
Ren X, Wang D, Zhang G, Zhou T, Wei Z, Yang Y, et al. Nucleic DHX9 cooperates with STAT1 to transcribe interferon-stimulated genes. Sci Adv. 2023;9:eadd5005.
Nakajima T, Uchida C, Anderson SF, Lee CG, Hurwitz J, Parvin JD, et al. RNA helicase A mediates association of CBP with RNA polymerase II. Cell. 1997;90:1107–12.
Lu J, Wu T, Zhang B, Liu S, Song W, Qiao J, et al. Types of nuclear localization signals and mechanisms of protein import into the nucleus. Cell Commun Signal. 2021;19:60.
Zhao Y, Zagani R, Park SM, Yoshida N, Shah P, Reinecker HC. Microbial recognition by GEF-H1 controls IKKepsilon mediated activation of IRF5. Nat Commun. 2019;10:1349.
Ren X, Liu Q, Zhou P, Zhou T, Wang D, Mei Q, et al. DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells. Nat Commun. 2024;15:3080.
Delgado M, Rainwater RR, Heflin B, Urbaniak A, Butler K, Davidson M, et al. Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways. J Biol Chem. 2022;298:101939.
Hugle M, Belz K, Fulda S. Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs. Cell Death Differ. 2015;22:1946–56.
Sebastian J, Rathinasamy K. Microtubules and cell division: potential pharmacological targets in cancer therapy. Curr Drug Targets. 2023;24:889–918.
Jiao A, Sun C, Wang X, Lei L, Liu H, Li W, et al. DExD/H-box helicase 9 intrinsically controls CD8(+) T cell-mediated antiviral response through noncanonical mechanisms. Sci Adv. 2022;8:eabk2691.
Fuller-Pace FV. DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation. Nucleic Acids Res. 2006;34:4206–15.
Yang BZ, Liu MY, Chiu KL, Chien YL, Cheng CA, Chen YL, et al. DHX9 SUMOylation is required for the suppression of R-loop-associated genome instability. Nat Commun. 2024;15:6009.
Castro J, Daniels MH, Brennan D, Johnston B, Gotur D, Lee YT, et al. A potent, selective, small-molecule inhibitor of DHX9 abrogates proliferation of microsatellite instable cancers with deficient mismatch repair. Cancer Res. 2024;85:758–76.
Ng YC, Chung WC, Kang HR, Cho HJ, Park EB, Kang SJ, et al. A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-kappaB-mediated innate immunity against DNA virus infection. Nucleic Acids Res. 2018;46:9011–26.
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, et al. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017;546:667–70.
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315:801–10.
Wu J, Liu Q, Zhang X, Tan M, Li X, Liu P, et al. The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages. Cell Death Dis. 2022;13:653.
Wu J, Liu Q, Zhang X, Wu X, Zhao Y, Ren J. STING-dependent induction of lipid peroxidation mediates intestinal ischemia-reperfusion injury. Free Radical Biol Med. 2021;163:135–40.