Jennifer Newsom is going full scorched earth on President Donald Trump after he came for her husband, the governor of California … declaring she’s not letting a dig about dyslexia slide.

In a fiery IG video Monday, Jennifer shut it down fast, saying learning differences don’t define someone’s potential, but mocking them sure says a lot about you … calling Trump’s comments offensive and ignorant.

Jennifer doubled down, pointing out people with learning challenges work twice as hard to prove themselves — then flipped it, saying the one who’s actually unfit is Trump … and rattles off a list of facts about him she says prove it.

This all comes after Trump took a swipe at California Governor Gavin Newsom in the Oval Office Monday — calling him “low IQ” and saying he’s “all for people with learning disabilities, but not for my president.”