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Bacterial and fungal infections in infants born before 24 weeks’ gestation: a review

  • Field DJ, Dorling JS, Manktelow BN, Draper ES. Survival of extremely premature babies in a geographically defined population: prospective cohort study of 1994-9 compared with 2000–5. BMJ. 2008;336:1221–3. https://doi.org/10.1136/bmj.39555.670718.BE.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Allen MC, Donohue PK, Dusman AE. The limit of viability-neonatal outcome of infants born at 22 to 25 weeks’ gestation. N Engl J Med. 1993;329:1597–601. https://doi.org/10.1056/NEJM199311253292201.

    Article 
    PubMed 

    Google Scholar
     

  • Hack M, Fanaroff AA. Outcomes of extremely-low-birth-weight infants between 1982 and 1988. N Engl J Med. 1989;321:1642–7. https://doi.org/10.1056/NEJM198912143212405.

    Article 
    PubMed 

    Google Scholar
     

  • Higgins BV, Baer RJ, Steurer MA, Karvonen KL, Oltman SP, Jelliffe-Pawlowski LL, et al. Resuscitation, survival and morbidity of extremely preterm infants in California, 2011–2019. J Perinatol. 2024;44:209–16. https://doi.org/10.1038/s41372-023-01774-6.

    Article 
    PubMed 

    Google Scholar
     

  • Venkatesh KK, Lynch CD, Costantine MM, Backes CH, Slaughter JL, Frey HA, et al. Trends in active treatment of live-born neonates between 22 weeks 0 days and 25 weeks 6 days by gestational age and maternal race and ethnicity in the US, 2014 to 2020. JAMA. 2022;328:652–62. https://doi.org/10.1001/jama.2022.12841.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Doshi H, Shukla S, Patel S, Cudjoe GA, Boakye W, Parmar N, et al. National trends in survival and short-term outcomes of periviable births =24 weeks gestation in the United States, 2009 to 2018. Am J Perinatol. 2024;41:e94–e102. https://doi.org/10.1055/a-1845-2526.

    Article 
    PubMed 

    Google Scholar
     

  • Nadeau HC, Subramaniam A, Andrews WW. Infection and preterm birth. Semin Fetal Neonatal Med. 2016;21:100–5. https://doi.org/10.1016/j.siny.2015.12.008.

    Article 
    PubMed 

    Google Scholar
     

  • Humberg A, Hartel C, Rausch TK, Stichtenoth G, Jung P, Wieg C, et al. Active perinatal care of preterm infants in the German neonatal network. Arch Dis Child Fetal Neonatal Ed. 2020;105:190–5. https://doi.org/10.1136/archdischild-2018-316770.

    Article 
    PubMed 

    Google Scholar
     

  • Porta R, García-Muñoz Rodrigo F, Ávila-Álvarez A, Ventura PS, Izquierdo Renau M, Ginovart G, et al. Active approach in delivery room and survival of infants born between 22 and 26 gestational weeks are increasing in Spain. Acta Paediatr. 2023;112:417–23. https://doi.org/10.1111/apa.16625.

    Article 
    PubMed 

    Google Scholar
     

  • Perez K, Puia-Dumitrescu M, Comstock BA, Wood TR, Mayock DE, Heagerty PJ, et al. Patterns of infections among extremely preterm infants. J Clin Med. 2023;12 https://doi.org/10.3390/jcm12072703.

  • Patel RM, Kandefer S, Walsh MC, Bell EF, Carlo WA, Laptook AR, et al. Causes and timing of death in extremely premature infants from 2000 through 2011. N Engl J Med. 2015;372:331–40. https://doi.org/10.1056/NEJMoa1403489.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Flannery DD, Puopolo KM, Hansen NI, Sanchez PJ, Stoll BJ, Eunice Kennedy Shriver National Institute of Child H, et al. Neonatal infections: insights from a multicenter longitudinal research collaborative. Semin Perinatol. 2022;46:151637 https://doi.org/10.1016/j.semperi.2022.151637.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Flannery DD, Edwards EM, Puopolo KM, Horbar JD. Early-onset sepsis among very preterm infants. Pediatrics. 2021;148 https://doi.org/10.1542/peds.2021-052456.

  • Flannery DD, Edwards EM, Coggins SA, Horbar JD, Puopolo KM. Late-onset sepsis among very preterm infants. Pediatrics. 2022;150 https://doi.org/10.1542/peds.2022-058813

  • Stoll BJ, Puopolo KM, Hansen NI, Sanchez PJ, Bell EF, Carlo WA, et al. Early-onset neonatal sepsis, 2015 to 2017, the rise of Escherichia Coli, and the need for novel prevention strategies. JAMA Pediatr. 2020;174:e200593 https://doi.org/10.1001/jamapediatrics.2020.0593.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Schrag SJ, Farley MM, Petit S, Reingold A, Weston EJ, Pondo T, et al. Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014. Pediatrics. 2016;138 https://doi.org/10.1542/peds.2016-2013.

  • Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993–2012. JAMA. 2015;314:1039–51. https://doi.org/10.1001/jama.2015.10244.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mukhopadhyay S, Puopolo KM. Risk assessment in neonatal early-onset sepsis. Semin Perinatol. 2012;36:408–15. https://doi.org/10.1053/j.semperi.2012.06.002.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Puopolo KM, Benitz WE, Zaoutis TE, Committee On F, Newborn, Committee On Infectious D. Management of Neonates Born at =34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018;142 https://doi.org/10.1542/peds.2018-2896.

  • Guo L, Han W, Su Y, Wang N, Chen X, Ma J, et al. Perinatal risk factors for neonatal early-onset sepsis: a meta-analysis of observational studies. J Matern Fetal Neonatal Med. 2023;36:2259049 https://doi.org/10.1080/14767058.2023.2259049.

    Article 
    PubMed 

    Google Scholar
     

  • Klinger G, Levy I, Sirota L, Boyko V, Reichman B, Lerner-Geva L, et al. Epidemiology and risk factors for early-onset sepsis among very-low-birthweight infants. Am J Obstet Gynecol. 2009;201:38 e1–6. https://doi.org/10.1016/j.ajog.2009.03.006.

    Article 
    PubMed 

    Google Scholar
     

  • Puopolo KM, Mukhopadhyay S, Hansen NI, Cotten CM, Stoll BJ, Sanchez PJ, et al. Identification of extremely premature infants at low risk for early-onset sepsis. pediatrics. 2017;140 https://doi.org/10.1542/peds.2017-0925.

  • Flannery DD, Mukhopadhyay S, Morales KH, Dhudasia MB, Passarella M, Gerber JS, et al. Delivery characteristics and the risk of early-onset neonatal sepsis. Pediatrics. 2022;149 https://doi.org/10.1542/peds.2021-052900.

  • Klinger G, Bromiker R, Zaslavsky-Paltiel I, Klinger S, Sokolover N, Lerner-Geva L, et al. Late-onset sepsis in very low birth weight infants. Pediatrics. 2023;152 https://doi.org/10.1542/peds.2023-062223.

  • Greenberg RG, Kandefer S, Do BT, Smith PB, Stoll BJ, Bell EF, et al. Late-onset sepsis in extremely premature infants: 2000–2011. Pediatr Infect Dis J. 2017;36:774–9. https://doi.org/10.1097/INF.0000000000001570.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely preterm infants from the NICHD neonatal research network. Pediatrics. 2010;126:443–56. https://doi.org/10.1542/peds.2009-2959.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • El Manouni El Hassani S, Berkhout DJC, Niemarkt HJ, Mann S, de Boode WP, Cossey V, et al. Risk factors for late-onset sepsis in preterm infants: a multicenter case-control study. Neonatology. 2019;116:42–51. https://doi.org/10.1159/000497781.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shuai X, Li X, Wu Y. Prediction for late-onset sepsis in preterm infants based on data from East China. Front Pediatr. 2022;10:924014 https://doi.org/10.3389/fped.2022.924014.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Visscher MO, Adam R, Brink S, Odio M. Newborn infant skin: physiology, development, and care. Clin Dermatol. 2015;33:271–80. https://doi.org/10.1016/j.clindermatol.2014.12.003.

    Article 
    PubMed 

    Google Scholar
     

  • Melville JM, Moss TJ. The immune consequences of preterm birth. Front Neurosci. 2013;7:79 https://doi.org/10.3389/fnins.2013.00079.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim JK, Chang YS, Sung S, Ahn SY, Park WS. Trends in the incidence and associated factors of late-onset sepsis associated with improved survival in extremely preterm infants born at 23-26 weeks’ gestation: a retrospective study. BMC Pediatr. 2018;18:172 https://doi.org/10.1186/s12887-018-1130-y.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Testoni D, Hornik CP, Guinsburg R, Clark RH, Greenberg RG, Benjamin DK Jr., et al. Early lumbar puncture and risk of intraventricular hemorrhage in very low birth weight infants. Early Hum Dev. 2018;117:1–6. https://doi.org/10.1016/j.earlhumdev.2017.11.013.

    Article 
    PubMed 

    Google Scholar
     

  • Benitz WE, Han MY, Madan A, Ramachandra P. Serial serum C-reactive protein levels in the diagnosis of neonatal infection. Pediatrics. 1998;102:E41 https://doi.org/10.1542/peds.102.4.e41.

    Article 
    PubMed 

    Google Scholar
     

  • Kosmeri C, Giapros V, Serbis A, Baltogianni M Application of advanced molecular methods to study early-onset neonatal sepsis. Int J Mol Sci. 2024;25 https://doi.org/10.3390/ijms25042258.

  • Flannery DD, Zevallos Barboza A, Mukhopadhyay S, Gerber JS, McDonough M, Shu D, et al. Antibiotic use among extremely low birth-weight infants from 2009 to 2021: a retrospective observational study. Arch Dis Child Fetal Neonatal Ed. 2024. https://doi.org/10.1136/archdischild-2023-326734.

  • Schrag SJ, Hadler JL, Arnold KE, Martell-Cleary P, Reingold A, Schuchat A. Risk factors for invasive, early-onset Escherichia coli infections in the era of widespread intrapartum antibiotic use. Pediatrics. 2006;118:570–6. https://doi.org/10.1542/peds.2005-3083.

    Article 
    PubMed 

    Google Scholar
     

  • Prevention of Group B streptococcal early-onset disease in newborns: ACOG committee opinion, number 797. Obstet Gynecol. 2020;135:e51-e72. https://doi.org/10.1097/AOG.0000000000003668.

  • Chen VL, Avci FY, Kasper DL. A maternal vaccine against group B streptococcus: past, present, and future. Vaccine. 2013;31:D13–9. https://doi.org/10.1016/j.vaccine.2012.12.080.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Polin RA, Denson S, Brady MT Committee on F, Newborn, Committee on Infectious D. Strategies for prevention of health care-associated infections in the NICU. Pediatrics. 2012;129:e1085–93. https://doi.org/10.1542/peds.2012-0145.

    Article 
    PubMed 

    Google Scholar
     

  • Benjamin DK Jr, Stoll BJ, Gantz MG, Walsh MC, Sanchez PJ, Das A, et al. Neonatal candidiasis: epidemiology, risk factors, and clinical judgment. Pediatrics. 2010;126:e865–73. https://doi.org/10.1542/peds.2009-3412.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aliaga S, Clark RH, Laughon M, Walsh TJ, Hope WW, Benjamin DK, et al. Changes in the incidence of candidiasis in neonatal intensive care units. Pediatrics. 2014;133:236–42. https://doi.org/10.1542/peds.2013-0671.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lausch KR, Dungu KHS, Callesen MT, Schroder H, Rosthoj S, Poulsen A, et al. Pediatric candidemia epidemiology and morbidities: a nationwide cohort. Pediatr Infect Dis J. 2019;38:464–9. https://doi.org/10.1097/Inf.0000000000002207.

    Article 
    PubMed 

    Google Scholar
     

  • Kelly MS, Benjamin DK Jr, Smith PB. The epidemiology and diagnosis of invasive candidiasis among premature infants. Clin Perinatol. 2015;42:105–17. https://doi.org/10.1016/j.clp.2014.10.008.

    Article 
    PubMed 

    Google Scholar
     

  • Ali GY, Algohary EH, Rashed KA, Almoghanum M, Khalifa AA. Prevalence of Candida colonization in preterm newborns and VLBW in the neonatal intensive care unit: role of maternal colonization as a risk factor in transmission of disease. J Matern Fetal Neonatal Med. 2012;25:789–95. https://doi.org/10.3109/14767058.2011.622005.

    Article 
    PubMed 

    Google Scholar
     

  • Magobo RE, Naicker SD, Wadula J, Nchabeleng M, Coovadia Y, Hoosen A, et al. Detection of neonatal unit clusters of Candida parapsilosis fungaemia by microsatellite genotyping: results from laboratory-based sentinel surveillance, South Africa, 2009–2010. Mycoses. 2017;60:320–7. https://doi.org/10.1111/myc.12596.

    Article 
    PubMed 

    Google Scholar
     

  • Cook A, Ferreras-Antolin L, Adhisivam B, Ballot D, Berkley JA, Bernaschi P, et al. Neonatal invasive candidiasis in low- and middle-income countries: data from the NeoOBS study. Med Mycol. 2023;61 https://doi.org/10.1093/mmy/myad010.

  • Ramya GM, Balakrishnan U, Chandrasekaran A, Abiramalatha T, Amboiram P, Sekar U, et al. Candida auris, an emerging pathogen—Challenge in the survival of microprimies. Indian J Med Microbiol. 2021;39:367–9. https://doi.org/10.1016/j.ijmmb.2021.03.025.

    Article 
    PubMed 

    Google Scholar
     

  • Sokou R, Palioura AE, Kopanou Taliaka P, Konstantinidi A, Tsantes AG, Piovani D, et al. Candida auris infection, a rapidly emerging threat in the neonatal intensive care units: a systematic review. J Clin Med. 2024;13 https://doi.org/10.3390/jcm13061586.

  • Chowdhary A, Stielow JB, Upadhyaya G, Singh PK, Singh A, Meis JF. Candida blankii: an emerging yeast in an outbreak of fungaemia in neonates in Delhi, India. Clin Microbiol Infect. 2020;26 https://doi.org/10.1016/j.cmi.2020.01.001.

  • Autmizguine J, Smith PB, Prather K, Bendel C, Natarajan G, Bidegain M, et al. Effect of fluconazole prophylaxis on fluconazole susceptibility in premature infants. J Antimicrob Chemother. 2018;73:3482–7. https://doi.org/10.1093/jac/dky353.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Parikh TB, Nanavati RN, Patankar CV, Rao S, Bisure K, Udani RH, et al. Fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants. Indian Pediatr. 2007;44:830–7.

    PubMed 

    Google Scholar
     

  • Kilpatrick R, Scarrow E, Hornik C, Greenberg RG. Neonatal invasive candidiasis: updates on clinical management and prevention. Lancet Child Adolesc Health. 2022;6:60–70. https://doi.org/10.1016/S2352-4642(21)00272-8.

    Article 
    PubMed 

    Google Scholar
     

  • Lawrence SM, Corriden R, Nizet V. Age-appropriate functions and dysfunctions of the neonatal neutrophil. Front Pediatr. 2017;5:23 https://doi.org/10.3389/fped.2017.00023.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang X, Zhivaki D, Lo-Man R. Unique aspects of the perinatal immune system. Nat Rev Immunol. 2017;17:495–507. https://doi.org/10.1038/nri.2017.54.

    Article 
    PubMed 

    Google Scholar
     

  • Medoro AK, Puopolo KM. Transplacental antibodies: role of maternal vaccines and immunity. Clin Perinatol. 2024 https://doi.org/10.1016/j.clp.2024.10.007.

  • Michalski C, Kan B, Lavoie PM. Antifungal immunological defenses in newborns. Front Immunol. 2017;8:281 https://doi.org/10.3389/fimmu.2017.00281.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mehler K, Cornely O, Seifert H, Zweigner J, Janssen S, Oberthuer A, et al. Molds and more: rare fungal infections in preterm infants https://doi.org/10.1097/INF.0000000000003407.

    Article 
    PubMed 

    Google Scholar
     

  • Weimer KED, Smith PB, Puia-Dumitrescu M, Aleem S. Invasive fungal infections in neonates: a review. Pediatr Res. 2022;91:404–12. https://doi.org/10.1038/s41390-021-01842-7.

    Article 
    PubMed 

    Google Scholar
     

  • Groll AH, Jaeger G, Allendorf A, Herrmann G, Schloesser R, von Loewenich V. Invasive pulmonary aspergillosis in a critically ill neonate: case report and review of invasive aspergillosis during the first 3 months of life. Clin Infect Dis. 1998;27:437–52. https://doi.org/10.1086/514717.

    Article 
    PubMed 

    Google Scholar
     

  • Walsh TJ. Primary cutaneous aspergillosis—an emerging infection among immunocompromised patients. Clin Infect Dis. 1998;27:453–7. https://doi.org/10.1086/514718.

    Article 
    PubMed 

    Google Scholar
     

  • Amod FC, Coovadia YM, Pillay T, Ducasse G. Primary cutaneous aspergillosis in ventilated neonates. Pediatr Infect Dis J. 2000;19:482–3. https://doi.org/10.1097/00006454-200005000-00022.

    Article 
    PubMed 

    Google Scholar
     

  • Stock C, Veyrier M, Magnin-Verschelde S, Duband S, Lavocat MP, Teyssier G, et al. [Primary cutaneous aspergillosis complicated with invasive aspergillosis in an extremely preterm infant: case report and literature review]. Arch Pediatr. 2010;17:1455–9. https://doi.org/10.1016/j.arcped.2010.04.012.

    Article 
    PubMed 

    Google Scholar
     

  • Etienne KA, Subudhi CP, Chadwick PR, Settle P, Moise J, Magill SS, et al. Investigation of a cluster of cutaneous aspergillosis in a neonatal intensive care unit. J Hosp Infect. 2011;79:344–8. https://doi.org/10.1016/j.jhin.2011.06.012.

    Article 
    PubMed 

    Google Scholar
     

  • James MJ, Lasker BA, McNeil MM, Shelton M, Warnock DW, Reiss E. Use of a repetitive DNA probe to type clinical and environmental isolates of Aspergillus flavus from a cluster of cutaneous infections in a neonatal intensive care unit. J Clin Microbiol. 2000;38:3612–8. https://doi.org/10.1128/JCM.38.10.3612-3618.2000.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Valdez-Martínez A, Santoyo-Alejandre MI, Arenas R, Fuentes-Venado CE, Ramírez-Lozada T, Bastida-González F, et al. Neonatal Mucormycosis: a rare but highly lethal fungal infection in term and preterm newborns—a 20-year systematic review. Trop Med Infect Dis. 2025;10:86.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Murphy CR, Teoh Z, Whitehurst D, Brammer C, Perkins K, Paulsen G, et al. Disseminated disease after candidemia in children and young adults: epidemiology, diagnostic evaluation and risk factors. Pediatr Infect Dis J. 2024;43:328–32. https://doi.org/10.1097/INF.0000000000004212.

    Article 
    PubMed 

    Google Scholar
     

  • Wynn JL, Tan S, Gantz MG, Das A, Goldberg RN, Adams-Chapman I, et al. Outcomes following candiduria in extremely low birth weight infants. Clin Infect Dis. 2012;54:331–9. https://doi.org/10.1093/cid/cir800.

    Article 
    PubMed 

    Google Scholar
     

  • Clancy CJ, Nguyen MH. Finding the “missing 50%“ of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. Clin Infect Dis. 2013;56:1284–92. https://doi.org/10.1093/cid/cit006.

    Article 
    PubMed 

    Google Scholar
     

  • Telenti A, Steckelberg JM, Stockman L, Edson RS, Roberts GD. Quantitative blood cultures in candidemia. Mayo Clin Proc. 1991;66:1120–3. https://doi.org/10.1016/s0025-6196(12)65791-7.

    Article 
    PubMed 

    Google Scholar
     

  • Pfeiffer CD, Samsa GP, Schell WA, Reller LB, Perfect JR, Alexander BD. Quantitation of Candida CFU in initial positive blood cultures. J Clin Microbiol. 2011;49:2879–83. https://doi.org/10.1128/JCM.00609-11.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Benjamin DK Jr., Stoll BJ, Fanaroff AA, McDonald SA, Oh W, Higgins RD, et al. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006;117:84–92. https://doi.org/10.1542/peds.2004-2292.

    Article 
    PubMed 

    Google Scholar
     

  • Lancaster DP, Friedman DF, Chiotos K, Sullivan KV. Blood volume required for detection of low levels and ultralow levels of organisms responsible for neonatal bacteremia by use of BACTEC Peds Plus/F, Plus Aerobic/F Medium, and the BD BACTEC FX system: an in vitro study. J Clin Microbiol. 2015;53:3609–13. https://doi.org/10.1128/JCM.01706-15.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cohen-Wolkowiez M, Smith PB, Mangum B, Steinbach WJ, Alexander BD, Cotten CM, et al. Neonatal Candida meningitis: significance of cerebrospinal fluid parameters and blood cultures. J Perinatol. 2007;27:97–100. https://doi.org/10.1038/sj.jp.7211628.

    Article 
    PubMed 

    Google Scholar
     

  • Huppler AR, Fisher BT, Lehrnbecher T, Walsh TJ, Steinbach WJ. Role of molecular biomarkers in the diagnosis of invasive fungal diseases in children. J Pediatr Infect Dis Soc. 2017;6:S32–S44. https://doi.org/10.1093/jpids/pix054.

    Article 

    Google Scholar
     

  • Cliquennois P, Scherdel P, Lavergne RA, Flamant C, Morio F, Cohen JF, et al. Serum (1 -> 3)-beta-D-glucan could be useful to rule out invasive candidiasis in neonates with an adapted cut-off. Acta Paediatr. 2021;110:79–84. https://doi.org/10.1111/apa.15321.

    Article 
    PubMed 

    Google Scholar
     

  • Ferreras-Antolin L, Aziz N, Warris A. Serial (1-3)-beta-D-Glucan (BDG) monitoring shows high variability among premature neonates. Med Mycol. 2022;60 https://doi.org/10.1093/mmy/myac032.

  • Manzoni P, Castagnola E, Mostert M, Sala U, Galletto P, Gomirato G. Hyperglycaemia as a possible marker of invasive fungal infection in preterm neonates. Acta Paediatr. 2006;95:486–93. https://doi.org/10.1080/08035250500444867.

    Article 
    PubMed 

    Google Scholar
     

  • Sola MC, Del Vecchio A, Rimsza LM. Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. Clin Perinatol. 2000;27:655–79. https://doi.org/10.1016/s0095-5108(05)70044-0.

    Article 
    PubMed 

    Google Scholar
     

  • Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62:e1–50. https://doi.org/10.1093/cid/civ933.

    Article 
    PubMed 

    Google Scholar
     

  • Arrieta AC, Shea K, Dhar V, Cleary JP, Kukreja S, Morris M, et al. Once-weekly liposomal amphotericin B as Candida prophylaxis in very low birth weight premature infants: a prospective, randomized, open-label, placebo-controlled pilot study. Clin Ther. 2010;32:265–71. https://doi.org/10.1016/j.clinthera.2010.02.016.

    Article 
    PubMed 

    Google Scholar
     

  • Caudle KE, Inger AG, Butler DR, Rogers PD. Echinocandin use in the neonatal intensive care unit. Ann Pharmacother. 2012;46:108–16. https://doi.org/10.1345/aph.1Q346.

    Article 
    PubMed 

    Google Scholar
     

  • Mohamed WA, Ismail M. A randomized, double-blind, prospective study of caspofungin vs. amphotericin B for the treatment of invasive candidiasis in newborn infants. J Trop Pediatr. 2012;58:25–30. https://doi.org/10.1093/tropej/fmr025.

    Article 
    PubMed 

    Google Scholar
     

  • Jeon GW, Koo SH, Lee JH, Hwang JH, Kim SS, Lee EK, et al. A comparison of AmBisome to amphotericin B for treatment of systemic candidiasis in very low birth weight infants. Yonsei Med J. 2007;48:619–26. https://doi.org/10.3349/ymj.2007.48.4.619.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ascher SB, Smith PB, Watt K, Benjamin DK, Cohen-Wolkowiez M, Clark RH, et al. Antifungal therapy and outcomes in infants with invasive Candida infections. Pediatr Infect Dis J. 2012;31:439–43. https://doi.org/10.1097/INF.0b013e3182467a72.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Warris A, Lehrnbecher T, Roilides E, Castagnola E, Bruggemann RJM, Groll AH. ESCMID-ECMM guideline: diagnosis and management of invasive aspergillosis in neonates and children. Clin Microbiol Infect. 2019;25:1096–113. https://doi.org/10.1016/j.cmi.2019.05.019.

    Article 
    PubMed 

    Google Scholar
     

  • Santos RP, Sanchez PJ, Mejias A, Benjamin DK Jr, Walsh TJ, Patel S, et al. Successful medical treatment of cutaneous aspergillosis in a premature infant using liposomal amphotericin B, voriconazole and micafungin. Pediatr Infect Dis J. 2007;26:364–6. https://doi.org/10.1097/01.inf.0000258698.98370.89.

    Article 
    PubMed 

    Google Scholar
     

  • Chitnis AS, Magill SS, Edwards JR, Chiller TM, Fridkin SK, Lessa FC. Trends in central line-associated bloodstream infections among NICUs, 1999-2009. Pediatrics. 2012;130:E46–E52. https://doi.org/10.1542/peds.2011-3620.

    Article 
    PubMed 

    Google Scholar
     

  • Manzoni P, Farina D, Leonessa M, d’Oulx EA, Galletto P, Mostert M, et al. Risk factors for progression to invasive fungal infection in preterm neonates with fungal colonization. Pediatrics. 2006;118:2359–64. https://doi.org/10.1542/peds.2006-1311.

    Article 
    PubMed 

    Google Scholar
     

  • Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK, et al. The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006;118:717–22. https://doi.org/10.1542/peds.2005-2677.

    Article 
    PubMed 

    Google Scholar
     

  • Kaufman DA, Manzoni P. Strategies to prevent invasive candidal infection in extremely preterm infants. Clin Perinatol. 2010;37:611 https://doi.org/10.1016/j.clp.2010.06.003.

    Article 
    PubMed 

    Google Scholar
     

  • Kaufman DA. “Getting to Zero”: Preventing invasive infections and eliminating infection-related mortality and morbidity in extremely preterm infants. Early Hum Dev. 2012;88:S45–S49. https://doi.org/10.1016/S0378-3782(12)70014-2.

    Article 
    PubMed 

    Google Scholar
     

  • Healy CM, Campbell JR, Zaccaria E, Baker CJ. Fluconazole prophylaxis in extremely low birth weight neonates reduces invasive candidiasis mortality rates without the emergence of fluconazole-resistant species. Pediatrics. 2008;121:703–10. https://doi.org/10.1542/peds.2007-1130.

    Article 
    PubMed 

    Google Scholar
     

  • Visscher MO, McKeown K, Nurre M, Strange R, Mahan T, Kinnett M, et al. Skin care for the extremely low-birthweight infant. Neoreviews. 2023;24:e229–e242. https://doi.org/10.1542/neo.24-4-e229.

    Article 
    PubMed 

    Google Scholar
     

  • Agren J, Sjors G, Sedin G. Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants. J Pediatr. 2006;148:613–7. https://doi.org/10.1016/j.jpeds.2005.11.027.

    Article 
    PubMed 

    Google Scholar
     

  • Sandberg K, Fasth A, Berger A, Eibl M, Isacson K, Lischka A, et al. Preterm infants with low immunoglobulin G levels have increased risk of neonatal sepsis but do not benefit from prophylactic immunoglobulin G. J Pediatr. 2000;137:623–8. https://doi.org/10.1067/mpd.2000.109791.

    Article 
    PubMed 

    Google Scholar
     

  • Weisman LE, Stoll BJ, Kueser TJ, Rubio TT, Frank CG, Heiman HS, et al. Intravenous immune globulin therapy for early-onset sepsis in premature neonates. J Pediatr. 1992;121:434–43. https://doi.org/10.1016/s0022-3476(05)81802-5.

    Article 
    PubMed 

    Google Scholar
     

  • Alshaikh BN, Ting J, Lee S, Lemyre B, Wong J, Afifi J, et al. Effectiveness and risks of probiotics in preterm infants. Pediatrics. 2025;155 https://doi.org/10.1542/peds.2024-069102.

  • Zhang GQ, Hu HJ, Liu CY, Shakya S, Li ZY. Probiotics for preventing late-onset sepsis in preterm neonates: a PRISMA-compliant systematic review and meta-analysis of randomized controlled trials. Medicine. 2016;95:e2581 https://doi.org/10.1097/MD.0000000000002581.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dermyshi E, Wang Y, Yan C, Hong W, Qiu G, Gong X, et al. The “Golden Age” of probiotics: a systematic review and meta-analysis of randomized and observational studies in preterm infants. Neonatology. 2017;112:9–23. https://doi.org/10.1159/000454668.

    Article 
    PubMed 

    Google Scholar
     

  • Rao SC, Athalye-Jape GK, Deshpande GC, Simmer KN, Patole SK. Probiotic supplementation and late-onset sepsis in preterm infants: a meta-analysis. Pediatrics. 2016;137:e20153684 https://doi.org/10.1542/peds.2015-3684.

    Article 
    PubMed 

    Google Scholar
     

  • Chi C, Buys N, Li C, Sun J, Yin C. Effects of prebiotics on sepsis, necrotizing enterocolitis, mortality, feeding intolerance, time to full enteral feeding, length of hospital stay, and stool frequency in preterm infants: a meta-analysis. Eur J Clin Nutr. 2019;73:657–70. https://doi.org/10.1038/s41430-018-0377-6.

    Article 
    PubMed 

    Google Scholar
     

  • Baker M, Bhattarai B, Johnson PJ, Wade C, Micetic B, Mody K. The effect of a single dose of prophylactic vancomycin prior to peripherally inserted central catheter removal on sepsis. J Pediatr Pharmacol Ther. 2022;27:715–9. https://doi.org/10.5863/1551-6776-27.8.715.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kusari A, Han AM, Virgen CA, Matiz C, Rasmussen M, Friedlander SF, et al. Evidence-based skin care in preterm infants. Pediatr Dermatol. 2019;36:16–23. https://doi.org/10.1111/pde.13725.

    Article 
    PubMed 

    Google Scholar
     

  • Ciccia M, Chakrokh R, Molinazzi D, Zanni A, Farruggia P, Sandri F. Skin antisepsis with 0.05% sodium hypochlorite before central venous catheter insertion in neonates: a 2-year single-center experience. Am J Infect Control. 2018;46:169–72. https://doi.org/10.1016/j.ajic.2017.08.012.

    Article 
    PubMed 

    Google Scholar
     

  • Baltogianni M, Giapros V, Dermitzaki N. Recent challenges in diagnosis and treatment of invasive candidiasis in neonates. Children. 2024;11 https://doi.org/10.3390/children11101207.

  • Le J, Greenberg RG, Yoo Y, Clark RH, Benjamin DK Jr, Zimmerman KO, et al. Ampicillin dosing in premature infants for early-onset sepsis: exposure-driven efficacy, safety, and stewardship. J Perinatol. 2022;42:959–64. https://doi.org/10.1038/s41372-022-01344-2.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bhargava V, George L, Malloy M, Fonseca R. The role of a single dose of vancomycin in reducing clinical sepsis in premature infants prior to removal of peripherally inserted central catheter: a retrospective study. Am J Perinatol. 2018;35:990–3. https://doi.org/10.1055/s-0038-1632391.

    Article 
    PubMed 

    Google Scholar
     

  • Yan PR, Chi H, Chiu NC, Huang CY, Huang DT, Chang L, et al. Reducing catheter-related bloodstream infection risk of infant with a prophylactic antibiotic therapy before removing peripherally inserted central catheter: a retrospective study. J Microbiol Immunol Infect. 2022;55:1318–25. https://doi.org/10.1016/j.jmii.2021.09.016.

    Article 
    PubMed 

    Google Scholar
     

  • Lodha A, Furlan AD, Whyte H, Moore AM. Prophylactic antibiotics in the prevention of catheter-associated bloodstream bacterial infection in preterm neonates: a systematic review. J Perinatol. 2008;28:526–33. https://doi.org/10.1038/jp.2008.31.

    Article 
    PubMed 

    Google Scholar
     

  • Jajoo M, Manchanda V, Chaurasia S, Sankar MJ, Gautam H, Agarwal R, et al. Alarming rates of antimicrobial resistance and fungal sepsis in outborn neonates in North India. PLoS ONE. 2018;13:e0180705 https://doi.org/10.1371/journal.pone.0180705.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Folgori L, Bielicki J, Heath PT, Sharland M. Antimicrobial-resistant gram-negative infections in neonates: burden of disease and challenges in treatment. Curr Opin Infect Dis. 2017;30:281–8. https://doi.org/10.1097/QCO.0000000000000371.

    Article 
    PubMed 

    Google Scholar
     

  • Solomon S, Akeju O, Odumade OA, Ambachew R, Gebreyohannes Z, Van Wickle K, et al. Prevalence and risk factors for antimicrobial resistance among newborns with gram-negative sepsis. PLoS ONE. 2021;16:e0255410 https://doi.org/10.1371/journal.pone.0255410.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Flannery DD, Chiotos K, Gerber JS, Puopolo KM. Neonatal multidrug-resistant gram-negative infection: epidemiology, mechanisms of resistance, and management. Pediatr Res. 2022;91:380–91. https://doi.org/10.1038/s41390-021-01745-7.

    Article 
    PubMed 

    Google Scholar
     

  • Hope WW, Castagnola E, Groll AH, Roilides E, Akova M, Arendrup MC, et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: prevention and management of invasive infections in neonates and children caused by Candida spp. Clin Microbiol Infect. 2012;18:38–52. https://doi.org/10.1111/1469-0691.12040.

    Article 
    PubMed 

    Google Scholar
     

  • Mesini A, Saffioti C, Mariani M, Florio A, Medici C, Moscatelli A, et al. First case of Candida auris colonization in a preterm, extremely low-birth-weight newborn after vaginal delivery. J Fungi. 2021;7 https://doi.org/10.3390/jof7080649.

  • Ganeshkumar A, Muthuselvam M, Lima PMN, Rajaram R, Junqueira JC. Current perspectives of antifungal therapy: a special focus on Candida auris. J Fungi. 2024;10 https://doi.org/10.3390/jof10060408.

  • Brassington PJT, Klefisch FR, Graf B, Pfuller R, Kurzai O, Walther G, et al. Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multi-locus sequence typing scheme: a retrospective observational and genomic epidemiology study. Lancet Microbe. 2025;6:100949 https://doi.org/10.1016/j.lanmic.2024.07.012.

    Article 
    PubMed 

    Google Scholar
     

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