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This report presents pooled vaccine effectiveness (VE) estimates for the Pfizer XBB.1.5 monovalent COVID-19 vaccine dose towards hospitalisation and COVID-19-related demise in resident populations in eight European nations. The dose was administered through the 2023 autumn marketing campaign towards COVID-19. The research populations have been these aged ≥65 years dwelling in the neighborhood in Belgium, Denmark, Italy, the Netherlands (solely till December 2023), Norway (solely till February 2024), Portugal, Spain (Navarra) and Sweden (information protection to fifteen April 2024). The research was undertaken throughout the Vaccine Effectiveness Burden and Affect Research (VEBIS) venture.
The research interval coated on this report is October 2023 to April 2024. A retrospective cohort was constructed from linked digital well being information (EHR) in every nation. Nation-specific (stage) VE was estimated month-to-month, utilizing a research interval of eight weeks follow-up interval. Every month, the research interval was shifted forwards to the following month. Nation estimates have been then pooled collectively for every interval. The VE of the 2023 autumnal dose was estimated utilizing the not-yet-vaccinated eligible inhabitants as a reference inhabitants.
Between October 2023 and April 2024, the variety of people aged ≥80 years included within the evaluation throughout every research interval decreased from 5 to 4 million people who have been eligible for the 2023 autumnal dose, however who didn’t obtain it through the research interval. Within the 65-79-year age group, the variety of people eligible for the autumnal dose however who didn’t obtain it decreased from 12.5 to 9.8 million people. A complete of 63 876 hospitalisations attributable to COVID-19 and eight 212 COVID-19-related deaths have been reported.
People who acquired the 2023 autumnal dose had already acquired the next variety of COVID-19 vaccine doses by then in comparison with those that have been eligible however had not acquired the autumnal dose by the top of the research interval. There was additionally the next proportion of people with registered co-morbidities who acquired the vaccination. The effectiveness of the monovalent XBB.1.5 COVID-19 vaccine dose towards hospitalisation attributable to COVID-19 for the primary eight-week remark window (from the beginning of the campaigns in October to 25 November 2024) was 65% (95percentCI: 56 to 71) and 64% (95percentCI: 55 to 72) among the many inhabitants aged ≥80 and 65-79 years, respectively. Vaccine effectiveness towards COVID-19-related demise was 67% (95percentCI: 41 to 81) and 67% (95percentCI: 43 to 81) among the many inhabitants aged ≥80 and 65-79 years, respectively.
Vaccine effectiveness towards hospitalisation attributable to COVID-19 decreased steadily via the research interval, all the way down to 38% (95percentCI: 31 to 45) and 48% (95percentCI: 40 to 55) among the many inhabitants aged ≥80 and 65-79 years, respectively, on 1 January to 25 February 2024. Most of this lower could also be attributable to new SARS-CoV-2 variants changing into dominant, rising time since vaccination within the majority of the vaccinated inhabitants who acquired it in October, and even to biases, akin to a depletion of vulnerable people. Between February 2024 and April 2024, estimates had very low precision or couldn’t be drawn in some websites.
Vaccine effectiveness estimates towards COVID-19 associated deaths decreased equally to VE towards hospitalisation for ≥80-year-olds, however solely marginally among the many 65-79 years previous group. From 1 January to 25 February 2024, VE towards demise was 40% (95percentCI: 25 to 51) for ≥80-year-olds and 54% (95percentCI: 24 to 71) for 65-79-year-olds. Between February and April 2024 estimates had very low precision or couldn’t be drawn in some websites.
Total, the outcomes of this research point out that the 2023 autumnal dose was efficient in restoring safety towards hospitalisation and COVID-19-related demise. Nevertheless, VE declined over time and reached ≤55% for each outcomes and age teams after January 2024.
