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C > U mutations generate immunogenic peptides in SARS-CoV-2

  • Thomson, E. C. et al. Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell 184, 1171–1187.e20 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yao, H. et al. Patient-derived SARS-CoV-2 mutations impact viral replication dynamics and infectivity in vitro and with clinical implications in vivo. Cell Discov. 6, 76 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Plante, J. A. et al. Spike mutation D614G alters SARS-CoV-2 fitness. Nature 592, 116–121 (2021).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Mlcochova, P. et al. SARS-CoV-2 B.1.617.2 delta variant replication and immune evasion. Nature 599, 114–119 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Agerer, B. et al. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses. Sci. Immunol. 6, https://doi.org/10.1126/sciimmunol.abg6461 (2021).

  • Stanevich, O. V. et al. SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19. Nat. Commun. 14, 149 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hamelin, D. J. et al. The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner. Cell Syst. 13, 143–157 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Pretti, M. A. M., Galvani, R. G., Scherer, N. M., Farias, A. S. & Boroni, M. In silico analysis of mutant epitopes in new SARS-CoV-2 lineages suggest global enhanced CD8 + T cell reactivity and also signs of immune response escape. Infect. Genet. Evol. 99, 105236 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Matyášek, R. & Kovařík, A. Mutation patterns of human SARS-CoV-2 and bat RaTG13 coronavirus genomes are strongly biased towards C>U transitions, indicating rapid evolution in theirhosts. Genes 11, 761 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Simmonds, P. Rampant C→U hypermutation in the genomes of SARS-CoV-2 and other coronaviruses: causes and consequences for their short- and long-term evolutionary trajectories. mSphere 5, e00408–e00420 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Di Giorgio, S., Martignano, F., Torcia, M. G., Mattiuz, G. & Conticello, S. G. Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2. Sci. Adv. 6, eabb5813 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hadfield, J. et al. Nextstrain: real-time tracking of pathogen evolution. Bioinformatics 34, 4121–4123 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wu, A. et al. One year of SARS-CoV-2 evolution. Cell Host Microbe 29, 503–507 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rice, A. M. et al. Evidence for strong mutation Bias toward, and selection against, U content in SARS-CoV-2: implications for vaccine design. Mol. Biol. Evol. 38, 67–83 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sadykov, M., Mourier, T., Guan, Q. & Pain, A. Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction. J. Mol. Cell Biol. 13, 225–227 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Graudenzi, A., Maspero, D., Angaroni, F., Piazza, R. & Ramazzotti, D. Mutational signatures and heterogeneous host response revealed via large-scale characterization of SARS-CoV-2 genomic diversity. iScience 24, 102116 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jurtz, V. et al. NetMHCpan-4.0: improved peptide-MHC class I interaction predictions integrating eluted ligand and peptide binding affinity data. J. Immunol. 199, 3360–3368 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Weiskopf, D. et al. Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 + T cells. Proc. Natl. Acad. Sci. USA. 110, E2046–E2053 (2013).

  • Koncz, B. et al. Self-mediated positive selection of T cells sets an obstacle to the recognition of nonself. Proc. Natl. Acad. Sci. USA 118, e2100542118 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bloom, J. D. & Neher, R. A. Fitness effects of mutations to SARS-CoV-2 proteins. Virus Evol. 9, vead055 (2024).

    Article 

    Google Scholar
     

  • Boichard, A. et al. APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. OncoImmunology 8, 1550341 (2019).

    Article 
    PubMed 

    Google Scholar
     

  • Kyte, J. & Doolittle, R. F. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105–132 (1982).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Sidney, J., Peters, B., Frahm, N., Brander, C. & Sette, A. HLA class I supertypes: a revised and updated classification. BMC Immunol. 9, 1 (2008).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Abi-Rached, L. et al. Immune diversity sheds light on missing variation in worldwide genetic diversity panels. PLoS ONE 13, e0206512 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579, 270–273 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li, Y. et al. The divergence between SARS-CoV-2 and RaTG13 might be overestimated due to the extensive RNA modification. Future Virol. 15, 341–347 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Vita, R. et al. The immune epitope database (IEDB): 2018 update. Nucleic Acids Res. 47, D339–D343 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Moss, P. The T cell immune response against SARS-CoV-2. Nat. Immunol. 23, 186–193 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Notarbartolo, S. et al. Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19. Sci. Immunol. 6, eabg5021 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Bergamaschi, L. et al. Longitudinal analysis reveals that delayed bystander CD8 + T cell activation and early immune pathology distinguish severe COVID-19 from mild disease. Immunity 54, 1257–1275 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rydyznski Moderbacher, C. et al. Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Cell 183, 996–1012.e19 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bange, E. M. et al. CD8 + T cells contribute to survival in patients with COVID-19 and hematologic cancer. Nat. Med. 27, 1280–1289 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Westmeier, J. et al. Impaired cytotoxic CD8 + T cell response in elderly COVID-19 patients. mBio 11, e02243–20 (2020).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Szabó, E. et al. Comparison of humoral and cellular immune responses in hematologic diseases following completed vaccination protocol with BBIBP-CorV, or AZD1222, or BNT162b2 vaccines against SARS-CoV-2. Front. Med. 10, 1176168 (2023).

    Article 

    Google Scholar
     

  • Mohammed, I. et al. The efficacy and effectiveness of the COVID-19 vaccines in reducing infection, severity, hospitalization, and mortality: a systematic review. Hum. Vaccin. Immunother. 18, 2027160 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Huang, C., Yang, L., Pan, J., Xu, X. & Peng, R. Correlation between vaccine coverage and the COVID-19 pandemic throughout the world: Based on real-world data. J. Med. Virol. 94, 2181–2187 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Garcia-Beltran, W. F. et al. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell 184, 2372–2383 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou, D. et al. Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera. Cell 184, 2348–2361 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hu, J. et al. Increased immune escape of the new SARS-CoV-2 variant of concern Omicron. Cell Mol. Immunol. 19, 293–295 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang, H. et al. Profiling CD8 + T cell epitopes of COVID-19 convalescents reveals reduced cellular immune responses to SARS-CoV-2 variants. Cell Rep. 36, 109708 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim, K. et al. The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness. Sci. Rep. 12, 14972 (2022).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nakata, Y. et al. Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome. Nucleic Acids Res. 51, 783–795 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, Y. et al. APOBEC3B edits HBV DNA and inhibits HBV replication during reverse transcription. Antivir. Res. 149, 16–25 (2018).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar
     

  • Turelli, P., Mangeat, B., Jost, S., Vianin, S. & Trono, D. Inhibition of hepatitis B virus replication by APOBEC3G. Science 303, 1829–1829 (2004).

    Article 
    PubMed 

    Google Scholar
     

  • Warren, C. J. et al. APOBEC3A Functions as a restriction factor of human papillomavirus. J. Virol. 89, 688–702 (2015).

    Article 
    PubMed 

    Google Scholar
     

  • Zhu, B. et al. Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance. Nat. Commun. 11, 886 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cheng, A. Z. et al. APOBECs and Herpesviruses. Viruses 13, 390 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nakaya, Y., Stavrou, S., Blouch, K., Tattersall, P. & Ross, S. R. In vivo examination of mouse APOBEC3- and human APOBEC3A- and APOBEC3G-mediated restriction of parvovirus and herpesvirus infection in mouse models. J. Virol. 90, 8005–8012 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Borzooee, F., Joris, K. D., Grant, M. D. & Larijani, M. APOBEC3G Regulation of the evolutionary race between adaptive immunity and viral immune escape is deeply imprinted in the HIV genome. Front. Immunol. 9, 3032 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Monajemi, M. et al. Positioning of APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8 + T Cells. PLoS ONE 9, e93428 (2014).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim, E.-Y. et al. Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural Infection. PLoS Pathog. 10, e1004281 (2014).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Squires, K. D., Monajemi, M., Woodworth, C. F., Grant, M. D. & Larijani, M. Impact of APOBEC mutations on CD8 + T cell recognition of HIV epitopes varies depending on the restricting HLA. JAIDS J. Acquir. Immune Defic. Syndr. 70, 172–178 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Norman, J. M. et al. The antiviral factor APOBEC3G enhances the recognition of HIV-infected primary T cells by natural killer cells. Nat. Immunol. 12, 975–983 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bradley, C. C. et al. Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence. Nat. Microbiol. 9, 1382–1392 (2024).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Augusto, D. G. et al. A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection. Nature 620, 128–136 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Le Bert, N. et al. Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection. J. Exp. Med. 218, e20202617 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Oran, D. P. & Topol, E. J. Prevalence of asymptomatic SARS-CoV-2 infection: a narrative review. Ann. Intern. Med. 173, 362–367 (2020).

    Article 
    PubMed 

    Google Scholar
     

  • Johansson, M. A. et al. SARS-CoV-2 Transmission from people without COVID-19 symptoms. JAMA Netw. Open 4, e2035057 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tan, J. et al. Transmission roles of symptomatic and asymptomatic COVID-19 cases: a modelling study. Epidemiol. Infect. 150, e171 (2022).

    Article 
    PubMed 

    Google Scholar
     

  • Emery, J. C. et al. The contribution of asymptomatic SARS-CoV-2 infections to transmission on the Diamond Princess cruise ship. ELife 9, e58699 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • van Dorp, L. et al. Emergence of genomic diversity and recurrent mutations in SARS-CoV-2. Infect. Genet. Evol. 83, 104351 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Directional mutational pressure affects the amino acid composition and hydrophobicity of proteins in bacteria. in Contemporary Issues in Genetics and Evolution 383–391 (Springer Netherlands, Dordrecht, 1998).

  • Simmonds, P. & Ansari, M. A. Extensive C->U transition biases in the genomes of a wide range of mammalian RNA viruses; potential associations with transcriptional mutations, damage- or host-mediated editing of viral RNA. PLoS Pathog. 17, e1009596 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Geoghegan, J. L., Duchêne, S. & Holmes, E. C. Comparative analysis estimates the relative frequencies of co-divergence and cross-species transmission within viral families. PLoS Pathog. 13, e1006215 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Woolhouse, M. E. J. Population biology of emerging and re-emerging pathogens. Trends Microbiol. 10, s3–s7 (2002).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kreuder Johnson, C. et al. Spillover and pandemic properties of zoonotic viruses with high host plasticity. Sci. Rep. 5, 14830 (2015).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Enard, D. & Petrov, D. A. Ancient RNA virus epidemics through the lens of recent adaptation in human genomes. Philos. Trans. R. Soc. B 375, 20190575 (2020).

    Article 
    CAS 

    Google Scholar
     

  • Huang, L., Kuhls, M. C. & Eisenlohr, L. C. Hydrophobicity as a driver of MHC class I antigen processing: Hydrophobicity in MHC class I peptide supply. EMBO J. 30, 1634–1644 (2011).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chen, H. et al. The immune response-related mutational signatures and driver genes in non-small-cell lung cancer. Cancer Sci. 110, 2348–2356 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Driscoll, C. B. et al. APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy. Nat. Commun. 11, 790 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • DiMarco, A. V. et al. APOBEC Mutagenesis inhibits breast cancer growth through induction of T cell–mediated antitumor immune Responses. Cancer Immunol. Res. 10, 70–86 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mullane, S. A. et al. Correlation of Apobec Mrna expression with overall survival and pd-l1 expression in urothelial carcinoma. Sci. Rep. 6, 27702 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Smid, M. et al. Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration. Nat. Commun. 7, 12910 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang, S., Jia, M., He, Z. & Liu, X.-S. APOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer. Oncogene 37, 3924–3936 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Conticello, S. G. The AID/APOBEC family of nucleic acid mutators. Genome Biol. 9, 229 (2008).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • O’Leary, M. A. et al. The placental mammal ancestor and the post–K-Pg radiation of placentals. Science 339, 662–667 (2013).

    Article 
    ADS 
    PubMed 

    Google Scholar
     

  • Gong, S., Xie, H. & Chen, F. Spatiotemporal changes of epidemics and their relationship with human living environments in China over the past 2200 years. Sci. China Earth Sci. 63, 1223–1226 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Morabia, A. Epidemic and population patterns in the Chinese Empire (243 b.c.e. to 1911 c.e.): quantitative analysis of a unique but neglected epidemic catalogue. Epidemiol. Infect. 137, 1361–1368 (2009).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Souilmi, Y. et al. An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia. Curr. Biol. 31, 3504–3514 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Morris, S. C. et al. Natural selection exerted by historical coronavirus epidemic(s): comparative genetic analysis in China Kadoorie Biobank and UK Biobank. Preprint at https://doi.org/10.1101/2024.02.06.579075 (2024).

  • Ihaka, R. & Gentleman, R. R: A language for data analysis and graphics. J. Comput. Graph. Stat. 5, 299–314 (1996).

    Article 

    Google Scholar
     

  • Wickham, H. ggplot2. WIREs Comput. Stats 3, 180–185 (2011).

    Article 

    Google Scholar
     

  • Kassambara, A. Ggpubr: ‘ggplot2’ Based Publication Ready Plots. (2025).

  • Gordon, M. & Lumley, T. Forestplot: Advanced Forest Plot Using ‘grid’ Graphics. (2025).

  • Kolde, R. Pheatmap: Pretty Heatmaps. (2025).

  • Robin, X. et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinform. 12, 77 (2011).

    Article 

    Google Scholar
     

  • Wilke, C. O. Cowplot: Streamlined Plot Theme and Plot Annotations for ‘Ggplot2’. (2025).

  • Ogle, D. H., Doll, J. C., Wheeler, A. P. & Dinno, A. FSA: simple fisheries stock assessment methods. https://doi.org/10.32614/CRAN.package.FSA (2015).

  • Kuznetsova, A., Brockhoff, P. B. & Christensen, R. H. B. lmertest package: tests in linear mixed effects models. J. Stat. Soft. 82, 1–26 (2017).

  • Solt, F. & Hu, Y. Dotwhisker: Dot-and-Whisker Plots of Regression Results. (2024).

  • Bolker, B. & Robinson, D. broom.mixed: Tidying methods for mixed models. https://doi.org/10.32614/CRAN.package.broom.mixed (2018).

  • Kassambara, A. rstatix: Pipe-friendly framework for basic statistical tests. https://doi.org/10.32614/CRAN.package.rstatix (2019).

  • Pohlert, T. PMCMRplus: Calculate pairwise multiple comparisons ofmean rank sums extended. https://doi.org/10.32614/CRAN.package.PMCMRplus (2018).

  • Klimczak, L. J., Randall, T. A., Saini, N., Li, J.-L. & Gordenin, D. A. Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic. PLoS ONE 15, e0237689 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Marty, R. et al. MHC-I Genotype restricts the oncogenic mutational landscape. Cell 171, 1272–1283 (2017).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to Multiple Testing. J. R. Stat. Soc. Ser. B Methodol. 57, 289–300 (1995).

    Article 
    MathSciNet 

    Google Scholar
     

  • Sarkizova, S. et al. A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nat. Biotechnol. 38, 199–209 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tremblay, B. J.-M. universalmotif: An R package for biological motifanalysis. JOSS 9, 7012 (2024).

    Article 
    ADS 

    Google Scholar
     

  • Brown, D. W., Myers, T. A. & Machiela, M. J. PCAmatchR: a flexible R package for optimal case–control matching using weighted principal components. Bioinformatics 37, 1178–1181 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • van Dorp, L. et al. No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2. Nat. Commun. 11, 1–8 (2020).


    Google Scholar
     

  • Honfi, D. et al. Comparison of homologous and heterologous booster SARS-CoV-2 vaccination in autoimmune rheumatic and musculoskeletal patients. IJMS 23, 11411 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Szebeni, G. J. et al. Humoral and cellular immunogenicity and safety of five different SARS-CoV-2 vaccines in patients with autoimmune rheumatic and musculoskeletal diseases in remission or with low disease activity and in healthy controls: a single center study. Front. Immunol. 13, 846248 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sudlow, C. et al. UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med. 12, e1001779 (2015).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Elliott, J. et al. COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors. Eur. J. Epidemiol. 36, 299–309 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rowlands, A. V. et al. Association between accelerometer-assessed physical activity and severity of COVID-19 in UK Biobank. Mayo Clin. Proc. Innov. Qual. Outcomes 5, 997–1007 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mathieu, E. et al. A global database of COVID-19 vaccinations. Nat. Hum. Behav. 5, 947–953 (2021).

    Article 
    PubMed 

    Google Scholar
     

  • Dobrijević, Z. et al. The association of human leucocyte antigen (HLA) alleles with COVID-19 severity: A systematic review and meta-analysis. Rev. Med. Virol. 33, e2378 (2023).

    Article 
    PubMed 

    Google Scholar
     

  • Balogh, G. et al. C > U mutations generate immunogenic peptides in SARS-CoV-2. Zenodo https://doi.org/10.5281/ZENODO.17019282 (2025).

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