2024 Week 1 NFL Picks, Odds & Best Bets from Advanced Model: This 5-way Football Parlay Pays Out 25-1

Caleb Williams and Will Levis will face off when Caleb’s Bears host Will Levis’ Titans as the Bears become 3.5 point favorites (down from an opening line of 4.5). Meanwhile, Russell Wilson and Kirk Cousins face-off while Atlanta remains as 3-point underdog against Pittsburgh for Week 1. However, considering their recent against-the-spread NFL betting trends in this matchup may make you choose Steelers over Falcons when selecting Week 1 NFL parlay picks for parlays. Falcons have gone just 1-11 both straight up and against the spread over their last 12 AFC North games against them since 2016. Pittsburgh is undefeated both straight up and against the spread in its last four matchups with Atlanta; history overwhelmingly favoring one team makes predictions difficult when making Week 1 NFL predictions in this case. Before selecting any Week 1 NFL picks or parlays for Week 1, make sure that you view SportsLine’s computer model’s predictions and betting advice before making your decisions. It has produced over $7,000 profit in profits since inception for $100 players on top-rated picks since running simulations 10,000 times on every NFL game! Starting back during 2017, this model has posted an incredible record of top-rated NFL picks (185-139) across eight seasons of prediction markets, beginning with Week 1 of 2024 NFL Season. Since Week 7 of 2017-18 NFL PickWatch model predictions have posted an overall winning record of 39-21 for top-rated picks that scored highly among readers and beat over 94% of CBS Sports Football Pick’em players four times! In total this makes an overall success record of over 90%! Anyone who has followed SportsLine is well aware that its model excels. Now, its Week 1 NFL odds-scanning algorithm has identified five solid picks. Should they all come true successfully parlayed together could yield payouts as large as 25-1! You can only see these picks over at SportsLine.
Top Week 1 NFL Picks By simulating each NFL game 10,000 times, our model suggests that Detroit Lions (-3.5) may cover in their home matchup against Los Angeles Rams at home this Sunday. Part of Detroit’s successful run to reach last season’s NFC Championship Game lay with its run defense which proved instrumental. The Lions were second in terms of fewest rushing yards allowed and third-lowest average yards per carry against opponents in 2017. As seen during their playoff meeting, when L.A. managed just 68 yards rushing during 2023 and Kyren Williams led with 95.3 average YPG; on Sunday night however, Williams is predicted to fall below that average by at least 30 yards. Detroit should face few issues running against an Aaron Donald-less defense as both David Montgomery and Jahmyr Gibbs are projected to rush for at least 55 yards each. As Jared Goff should outduel Matthew Stafford, Detroit (-3.5) should win by at least a touchdown and cover nearly 60% of times. Check back often as SportsLine will reveal which other NFL parlay picks should be considered here, along with tips to create Week 1 NFL parlays and best bets and parlay bets from SportsLine’s model. In addition, four more matchups in which it finds that lines are significantly off were also highlighted by this model; one home favorite in particular covered the spread in almost 70% of simulations! For all your Week 1 best bets and parlay options check SportsLine only!
What are SportsLine’s model’s top Week 1 NFL picks, and which other matchups should you target to achieve a 25-1 payout? Visit SportsLine now to view 185-129 top picks of last season and learn.

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