A penicillin-binding protein inhibitor series to target drug-resistant Neisseria gonorrhoeae
Compounds and chemical synthesis Boro-PBPi compounds were synthesized at Venatorx Pharmaceuticals, Inc. and BioDuro-Sundia as described in the ‘Chemistry experimental details’ section in the Supplementary Information. Ceftriaxone (USP, 1098184), azithromycin (USP, 1046056), ciprofloxacin (Sigma-Aldrich, 17850), cefoperazone (Alfa Aesar, J65185), zoliflodacin (MedChemExpress, HY-17647) and gepotidacin (MedChemExpress, HY-16742) were used. The Molecular Operating Environment (Chemical Computing Group) […]
Fresnillo share price rebounds as a FTSE 100 top mover after a 30% sell-off — what’s next?
Image source: Getty Images The Fresnillo (LSE: FRES) is back in focus today (8 April), emerging as one of the standout movers in the FTSE 100. After a six-fold surge in 2025 followed by a bruising 30% decline in recent months, the question now is whether sentiment is beginning to turn again for one of […]
EURUSD surges above the 1.17 handle as Trump announces a two-sided ceasefire. What’s next?
FUNDAMENTAL OVERVIEW USD: The US dollar sold off across the board today after Trump announced on Truth Social a two-sided ceasefire agreement for two weeks while the US and Iran negotiate a lasting peace deal. The discussions will begin on Friday in Islamabad and may be extended if both parties agree. Given the de-escalation, the […]
FC Porto v Nottingham Forest: Line-ups, stats and preview
Nottingham Forest head to Porto tomorrow trying to strike a balance between continuing their European adventure and Premier League survival. The international break came at the wrong time for boss Vitor Pereira following their hugely impressive 3-0 win at fellow strugglers Tottenham on March 22. Since then, Pereira has seen most of his squad depart […]
Up 8%: what’s going on with Lloyds shares today?
Image source: Getty Images Lloyds (LSE:LLOY) shares are surging more than 8% on Wednesday 8 April. The index is up too, but this still makes it one of the FTSE 100‘s biggest gainers. Unsurprisingly, it’s the ceasefire agreement between Iran and the US that’s doing the heavy lifting. Let’s take a closer look and explore […]
Eurozone February retail sales -0.2% vs -0.2% m/m expected
Prior -0.1%; revised to 0.0% Euro area retail sales dropped slightly in February but is still seen up 1.7% relative to the same month a year ago. The details show a 0.5% drop in sales for food, drinks, tobacco while retail sales for non-food products were stable on the month. Meanwhile, sales for automotive fuel […]
The BP and Shell share price are being hammered today – what should investors do?
Image source: Getty Images The Shell (LSE: SHEL) share price has plunged 6.5% so far this morning. Fellow oil and gas giant BP (LSE: BP) has fallen 7.5%. They’re easily the worst two performers on the FTSE 100 today (8 April). Yet BP and Shell investors have one consolation. The rest of the index is […]
US vice president Vance says Iran has agreed to open the Strait of Hormuz
There are good developments about Iran They have agreed to open the Strait of Hormuz US and allies have agreed to stop attacking Iran That’s the basis of the “fragile truce” currently Some people within Iran have responded very favourably to the truce US negotiating team to work in good faith to get to an […]
Kanye West’s Legal Issues Grow With Ex-Bodyguard Seeking Nearly $1M
Kanye West Ex-Security Guard Wants Nearly $1M Published April 8, 2026 3:00 AM PDT Kanye West’s issues continue to grow …. a former employee of the rapper is seeking close to $1 million in court for unpaid wages and other damages … TMZ has learned. According to court docs obtained by TMZ, Jonathan Monroe — […]
Barclays shares surge: stick or twist?
Image source: Getty Images Barclays (LSE:BARC) shares jumped almost 8% this morning (8 April). The stock is now up 72% over 12 months, but this doesn’t tell the whole story. Shares had pulled back as the market became increasingly worried about the negative impact of AI, and as the war in the Gulf damaged the […]
