Identification of soluble biomarkers that associate with distinct manifestations of long COVID
Study design The objective of this study was to characterize the immunological and proteomic features of long COVID. SARS-CoV-2 spike-specific antibody titers were measured using an enzyme-linked immunosorbent assay. Antibody neutralization activity and ADNKA were quantified against the England-2 strain of SARS-CoV-2. Immune cell lineages were profiled via multidimensional flow cytometry. Antigen-specific CD4+ and CD8+ […]
Discovery that microglia can be effectively replaced could transform cell therapy for brain diseases
Microglia in a brain tissue sample. Credit: Prof. Kiavash Movahedi An international research team led by Professor Kiavash Movahedi from the Brussels Center for Immunology at the Vrije Universiteit Brussel has published unexpected results in the journal Immunity. Their study sheds new light on the possibility of effectively replacing defective microglia—the brain’s immune cells—marking a […]
Jeff Sperbeck, John Elway’s Agent & Friend, Dead At 62 After Golf Cart Accident
John Elway’s Agent, Friend Jeff Sperbeck Dead At 62 Published April 30, 2025 10:47 AM PDT | Updated April 30, 2025 8:09 PM PDT Jeff Sperbeck, John Elway‘s longtime agent and friend, has died at 62 years old, officials announced on Wednesday. Sperbeck’s time of death was listed as 1:10 AM. As we previously reported, […]
Ruben Amorim Says Not Even Europa League Glory Can Save Manchester United’s Season
Ruben Amorim on Wednesday admitted that even winning the Europa League would not salvage Manchester United’s miserable season. The fallen English giants face Athletic Bilbao in the semi-finals, with the first leg in Spain on Thursday. But whatever the result at the San Mames, also the venue for May’s final, it will not […]
The BP share price is falling… but the dividend yield is rising
Image source: Getty Images Unlike several other parts of the market, oil and energy stocks haven’t recovered since Donald Trump announced his trade policy. And this is reflected in the BP (LSE:BP.) share price, which now sits marginally above three-year lows. Of course, corrections and crashes occasionally offer investors an opportunity. So, is this an […]
Labor Day holiday to keep things quiet in Europe
London markets will be open for trading though but the other major hubs in Europe are all closed in observance of Labor Day. As such, there will be lighter flows in general but that won’t stop an already busy-looking market to start the new month. The dollar is keeping steadier across the board, keeping with […]
Nanobody-mediated targeting of Plasmodium falciparum PfPIMMS43 can block malaria transmission in mosquitoes
Generation and characterization of VHH nanobodies targeting PfPIMMS43 PfPIMMS43 is a 505-amino acid protein with an N-terminal signal peptide and a C-terminal GPI anchor. To generate nanobodies against PfPIMMS43, we produced a recombinant Thioredoxin-His-tagged version of PfPIMMS43, excluding the signal peptide and GPI anchor sequences (amino acids 26-481), in Escherichia coli as previously described (Ukegbu […]
Many Medicaid enrollees have restricted access to SGLT2 inhibitors, GLP-1 receptor agonists
Many Medicaid enrollees with type 2 diabetes have restricted access to cardioprotective medications, including sodium-glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs), according to a study published online April 22 in the Annals of Internal Medicine. Using dipeptidyl peptidase-4 inhibitors (DPP4is) as a benchmark, Anil N. Makam, M.D., from UCSF at San […]
Tigers Sign Nick Margevicius To Minor League Contract
The Tigers reached agreement with left-hander Nick Margevicius on a minor league deal, relays Chris McCosky of The Detroit News. The 6’5″ southpaw had been pitching in the Mexican League with the Tecos de los Dos Laredos. Margevicius, 28, pitched in the majors each season from 2019-21. He suited up with both the Mariners and Padres, […]
Hawks’ Dyson Daniels Wins Most Improved Player Award – Basketball Insiders
Atlanta Hawks guard Dyson Daniels has won the NBA’s 2024-25 Most Improved Player Award. It is also now recognized as the George Mikan trophy. In his third season and first with Atlanta, Daniels averaged career highs of 14.1 points, 5.9 rebounds, 4.4 assists and 3.0 steals. He also shot career-highs of 49.3 percent from the […]
