Day: March 17, 2025

Australian dollar hits a three-week high without any help from the old ‘risk trade’

There was a time (most of the last two decades) when if we saw the S&P 500 fall 10%, the Australian dollar would be straight down with it. However the US tariff war has unleashed something different in markets and we’re seeing AUD holding up in the storm. To be fair, AUD/USD is still near […]

Early Release – Lower Frequency of Multiple Erythema Migrans Skin Lesions in Lyme Reinfections, Europe – Volume 31, Number 4—April 2025 – Emerging Infectious Diseases journal

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released. Author affiliation: University Medical Centre Ljubljana, Ljubljana, Slovenia (F. Strle, V. Maraspin, S. Lotrič-Furlan, K. Ogrinc, T. Rojko, P. Bogovic); University of Ljubljana, Ljubljana (A. Kastrin); Tufts […]

Differential efficacy of first licensed western vaccines protecting without immunopathogenesis Wuhan-1-challenged hamsters from severe COVID-19

Cells Vero clone E6 was purchased from ATCC (ATCC# CRL-1586, Manassas, VA, USA) and cultured in Dulbecco’s modified Eagle’s medium (DMEM, Sigma Aldrich, Steinheim, Germany) containing 10% fetal bovine serum (FBS; Sigma Aldrich, Steinheim, Germany) and 2 mM l-glutamine (l-Gln, Sigma Aldrich). Cell cultures were incubated at 37 °C in a humidified atmosphere containing 5% CO2 up […]

IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia

IL-1 is crucial for the immune defense against C. albicans Once systemic infection is established, C. albicans penetrates and grows in various organs of the host. In murine systemic candidiasis, the primary targets of fungal growth are the kidneys and brain. C. albicans is also found in the liver and spleen, though to a lesser […]

NGS-based Aspergillus detection in plasma and lung lavage of children with invasive pulmonary aspergillosis

Aim of this study The aim of this study is optimization of the microbial NGS workflow tailored to Aspergillus detection in liquid biopsy samples. This involves shotgun sequencing of liquid biopsy samples, such as blood or BAL fluid, with the objective of sequencing intact microbial wcDNA or small DNA molecules from degraded microbes (i.e., cell-free […]

Ubiquitination of gasdermin D N-terminal domain directs its membrane translocation and pore formation during pyroptosis

GD-NT, but not GD-FL, possesses K63-linked polyubiquitination To investigate the ubiquitination of GSDMD, the vectors expressing GD-FL, GD-NT, GD-CT, or caspase-11 were constructed (Fig. 1A, B). We transfected Flag-GD-FL/caspase-11 into HEK293 cells and performed IP & immunoblot assay. Interestingly, the result showed that GSDMD was slightly ubiquitinated when it was introduced into the cells alone. […]

Global burden of malaria before and after the COVID-19 pandemic based on the global burden of disease study 2021

Incidence In 2010, an estimated 0.26 billion (95% UI: 0.22 to 0.31 billion) incident cases of malaria were recorded globally. This number decreased to 0.24 billion (95% UI: 0.19 to 0.30 billion) by 2019; however, it rose again to 0.25 billion (95% UI: 0.20 to 0.32 billion) in 2021. The ASR of malaria incidence declined from 3,789.28 (95% UI: 3242.61 to […]

Just released: March’s higher-risk, high-reward stock recommendation [PREMIUM PICKS]

Image source: Getty Images Premium content from Motley Fool Share Advisor UK Investors following the Fire style are accepting higher risk with the goal of attaining higher returns over time. So this approach requires a higher risk tolerance, and the willingness to accept significant volatility in share prices. In October 2019, we also expanded the […]

Atlanta Fed GDPNow Q1 estimate -2.1% vs -1.6% prior

The Atlanta Fed Q1 GDP tracker was lowered to -2.1% from -1.6% in the latest update. After this morning’s retail sales release, the nowcast for first-quarter real personal consumption expenditures growth declined from 1.1 percent to 0.4 percent. A week ago, the Atlanta Fed noted that huge amounts of US gold imports were largely responsible […]

PepsiCo to buy Poppi for nearly $2B

Steak ‘n Shake COO Daniel Edwards joins ‘Fox & Friends’ to discuss the company making the switch from frying in vegetable oil to beef tallow. PepsiCo announced Monday that it will acquire prebiotic soda brand Poppi for $1.95 billion as the food and beverage giant seeks to tap into the heightened consumer demand for healthy […]