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The most important storylines, matchup keys and stat nuggets for NFL Week 5 -- plus picks: Our 13-game information

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October 4, 2024

The Week 5 NFL schedule for the 2024 season is stacked with nice matchups, and we have got you coated with what you’ll want to know heading into the weekend.

Our NFL Nation reporters carry us the largest keys to each recreation, and analytics author Seth Walder makes a daring prediction for every matchup. The ESPN Analysis group gives an enormous stat to know and a betting nugget for every contest, whereas our Football Power Index (FPI) goes contained in the numbers with a recreation projection. Fantasy analyst Eric Moody finds fantasy football X components, and three analysts — Kalyn Kahler, Moody and Walder — give us last rating picks for each recreation. The whole lot you need to know is right here in a single spot that will help you prepare for a loaded weekend of NFL football.

Let’s get into the complete Week 5 slate, together with the Jets and Vikings going through off in London and an AFC North showdown between the Ravens and the Bengals. All of it culminates with a “Monday Night time Soccer” matchup between the Saints and the Chiefs on ESPN. (Sport occasions are Sunday until in any other case famous.)

Soar to a matchup:
NYJ-MIN | CAR-CHI | BAL-CIN
MIA-NE | CLE-WSH | IND-JAX
BUF-HOU | LV-DEN | ARI-SF
GB-LAR | NYG-SEA | DAL-PIT
NO-KC

Thursday: ATL 36, TB 30
Byes: DET, TEN, PHI, LAC

9:30 a.m. ET | NFL Community | ESPN BET: MIN -2.5 (40.5 O/U)

Jets storyline to observe: This recreation is all about getting proper on offense. The go safety, particularly towards the blitz, must be quite a bit sharper than it was final week against the Broncos — 5 sacks and 14 quarterback hits. Aaron Rodgers has a sore left knee to indicate for it. The Jets have spent the week drilling down on their blitz pickups and route changes, anticipating a barrage from the blitz-heavy Vikings. Perhaps Rodgers’ familiarity with them will assist — he has 17 profession wins towards the Vikings (tied for essentially the most towards Minnesota). — Wealthy Cimini

Vikings storyline to observe: The Vikings are slight favorites to win and go 5-0 to begin the season, largely due to how the Jets’ offense regarded in Week 4. New York, which put up solely 9 factors towards Denver, did not look ready to deal with the type of play-to-play personnel substitutions the Vikings’ protection sometimes makes an attempt. Of the 85 groups which have began 5-0 within the Tremendous Bowl period (since 1966), 71 of them have gone on to make the playoffs. The final group that did not was the 2016 Vikings, who completed that season 8-8. — Kevin Seifert

Stat to know: Vikings large receiver Justin Jefferson has had a landing reception in each recreation this season; with one on Sunday, he can be a part of Randy Moss (2004) as the one gamers in Vikings historical past to have a receiving TD in every of group’s first 5 video games.

Daring prediction: The Jets’ protection will maintain Minnesota beneath 21 factors. I place confidence in the Jets’ corners to carry their very own even towards Jefferson and Jordan Addison. They might even make quarterback Sam Darnold see a ghost or two. Whether or not the Jets can rating sufficient to take benefit is one other query altogether. — Walder

Accidents: Jets | Vikings

Fantasy X issue: Jets large receiver Garrett Wilson. He had a tricky outing final week. Dangerous climate and a heavy dose of Broncos cornerback Pat Surtain II crushed the fantasy hopes of Wilson’s managers. The Vikings’ protection has struggled towards large receivers, permitting the third most fantasy factors per recreation. This units Wilson up for an epic efficiency, as he has the chance to take advantage of a softer matchup and bounce again in an enormous method. See Week 5 rankings. — Moody

Betting nugget: The Vikings are the primary group within the Tremendous Bowl period to begin 4-0 regardless of not being greater than a one-point favourite in any of their first 4 video games. Read more.

Kahler’s decide: Vikings 21, Jets 14
Moody’s decide: Vikings 27, Jets 16
Walder’s decide: Jets 23, Vikings 17
FPI prediction: MIN, 53.7% (by a mean of 1.5 factors)

Matchup must-reads: As Rodgers nears 60K yards, a look at every 10K milestoneDarnold, Vikings’ O earning coach O’Connell’s trustRodgers: Relationship with Robert Saleh ‘great’


1 p.m. ET | Fox | ESPN BET: CHI -4 (40.5 O/U)

Panthers storyline to observe: The Panthers will add two new inside linebackers to the center of a protection already with out Professional Bowl lineman Derrick Brown (knee, out for the season), security Jordan Fuller (hamstring) and probably nostril sort out Shy Tuttle (foot) because of accidents to Shaq Thompson (Achilles, out for the season) and Josey Jewell (hamstring). That places much more pressure on a unit that has given up a league-most 32.3 factors a recreation, one which ranks thirtieth in sacks (5) and the underside of the league in pressures (26). The lucky factor is the Panthers are going through a rookie quarterback in Caleb Williams and an offensive line that’s tied for Twenty ninth in sacks allowed (16) and the Carolina offense has put up 60 factors previously two video games since Andy Dalton took over at QB. — David Newton

Bears storyline to observe: Chicago has a chance to maintain its new-found success on the bottom going towards the Panthers’ Twenty ninth-ranked run protection. D’Andre Swift lastly broke by way of in each the run (93 yards) and go recreation (seven catches, 72 yards) final week and can look to do comparable injury towards a Carolina protection that’s permitting 149 speeding yards per recreation. On the end result of Week 5, the Bears could have confronted three of the 4 worst run defenses within the NFL (together with the Colts and the Rams) as they search for their eighth straight win at Soldier Subject. — Courtney Cronin

Stat to know: After averaging an NFL-worst 176 yards per recreation with Bryce Young at QB, the Panthers are averaging the fifth-most YPG (406) with Dalton.

Daring prediction: Williams has his first recreation with a QBR of greater than 60. Why? Williams has but to get publish a recreation over 40, and Carolina’s go protection ought to make life simpler, rating Twenty ninth in EPA allowed per opponent dropback. — Walder

Accidents: Panthers | Bears

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0:42

Why D’Andre Swift could possibly be in line for an enormous fantasy efficiency vs. Panthers

Subject Yates and Mike Clay talk about why the Bears’ recreation plan vs. the Panthers may imply an enormous fantasy efficiency for D’Andre Swift.

Fantasy X issue: Panthers working again Chuba Hubbard. Hubbard has racked up 22 or extra touches and 22 or extra fantasy factors in two straight video games. He additionally faces a Bears protection that has allowed the Tenth-most fantasy factors per recreation to working backs. Notable performances embrace 18.4 factors from Tony Pollard, 26.5 from Jonathan Taylor and 20.4 from Kyren Williams. With this matchup, Hubbard could possibly be in for an additional large day. See Week 5 rankings. — Moody

Betting nugget: The Bears have coated 4 straight video games when favored (2-0 towards the unfold this season). Read more.

Kahler’s decide: Bears 28, Panthers 17
Moody’s decide: Bears 27, Panthers 14
Walder’s decide: Bears 27, Panthers 20
FPI prediction: CHI, 63.3% (by a mean of 5.0 factors)

Matchup must-reads: Panthers’ loss to Bengals is something ‘we can build on’Bears P Taylor wins NFC special teams award


1 p.m. ET | CBS | ESPN BET: BAL -2.5 (49.5 O/U)

Ravens storyline to observe: When requested about the important thing to beating the Bengals, Ravens cornerback Marlon Humphrey mentioned it comes right down to the matchup between Baltimore’s secondary and Cincinnati’s large receivers. Within the Ravens’ 4 wins over QB Joe Burrow, Baltimore has held Cincinnati’s large receivers to a mean of 119.7 yards. Within the Ravens’ three losses to Burrow, Baltimore allowed the Bengals’ large receivers to common 287.3 yards. — Jamison Hensley

Bengals storyline to observe: This matchup could possibly be dictated by what occurred within the offseason. Cincinnati opted to get an inside defensive lineman who was more proficient at go speeding (Sheldon Rankins) than run stopping (DJ Reader). Baltimore has two gamers, QB Lamar Jackson and new RB Derrick Henry, who’re within the high 4 within the league in speeding yards earlier than first contact, per ESPN Analysis. — Ben Child

Stat to know: The Baltimore secondary has allowed a league-high 20 receptions of 20-plus yards.

Daring prediction: Ravens large receiver Zay Flowers bounces again from a chilly couple of weeks with a 100-plus-yard receiving efficiency. Flowers ranks seventh in open rating thus far, so he ought to have loads of targets coming his method. — Walder

Accidents: Ravens | Bengals

Fantasy X issue: Bengals large receiver Tee Higgins. He won’t get as a lot consideration as Ja’Marr Chase, however he led the group with 10 targets in Week 4. He has a good matchup this week towards a Ravens protection that enables the eighth-most fantasy factors per recreation to large receivers. Additionally, Higgins has averaged 12.0 fantasy factors per recreation in regular-season video games with Burrow when he will get six or extra targets. See Week 5 rankings. — Moody

Betting nugget: The Bengals had been 1-5 ATS in division video games final season. Read more.

Kahler’s decide: Ravens 30, Bengals 28
Moody’s decide: Ravens 30, Bengals 27
Walder’s decide: Ravens 30, Bengals 23
FPI prediction: BAL, 55.8% (by a mean of two.3 factors)

Matchup must-reads: Stiff-arming 30: Why Henry’s age-defying play has Ravens back on trackBengals, Burrow to ‘chase perfection’ in Ravens showdown


1 p.m. ET | Fox | ESPN BET: NE -1 (36.5 O/U)

Dolphins storyline to observe: The Dolphins will begin Tyler Huntley at quarterback for the second consecutive recreation and really feel assured in his ongoing acclimation inside this offense. Coach Mike McDaniel mentioned there have been, contextually, a whole lot of positives to remove from Huntley’s efficiency in Week 4, and that simply as Huntley learns the way to run this offense, Dolphins coaches are additionally studying the way to put him in the very best positions to succeed. Huntley may get a bolstered receiving corps to throw to; large receiver Odell Beckham Jr. returned to follow this week and is eligible to be activated for Sunday’s recreation. — Marcel Louis-Jacques

Patriots storyline to observe: Coach Jerod Mayo mentioned he is strongly considering having Antonio Gibson begin over Rhamondre Stevenson at working again, as Stevenson has fumbled in every of the primary 4 video games of the season (two recovered by opponents). The Dolphins recovered a fumble within the season opener towards the Jaguars however have not had one since. Each groups enter the matchup with a good turnover differential — 4 takeaways and 4 giveaways. — Mike Reiss

Stat to know: This contest might be a matchup between the 2 lowest-scoring groups within the NFL. Miami is averaging 11.3 factors per recreation and New England is averaging 13.0.

Daring prediction: Patriots defensive lineman Keion White will sack Huntley twice. White bought off to a red-hot begin with 4 sacks within the first two video games however hasn’t taken down the quarterback since. However I am nonetheless shopping for as he has a 23% go rush win price by way of 4 video games. We’re witnessing the beginning of a breakout marketing campaign. — Walder

Accidents: Dolphins | Patriots

Fantasy X issue: Stevenson. He began the season off sizzling, with 23-plus touches and 17-plus fantasy factors in every of the primary two video games. However previously two? Simply 23 touches and eight.5 factors mixed. The excellent news? If he begins, he has a way more favorable matchup this week towards the Dolphins, who’ve allowed the fifth-most fantasy factors to RBs. He is again on the RB2 radar. See Week 5 rankings. — Moody

Betting nugget: The Dolphins are 0-4 ATS this season. Read more.

Kahler’s decide: Patriots 14, Dolphins 12
Moody’s decide: Patriots 23, Dolphins 13
Walder’s decide: Dolphins 20, Patriots 13
FPI prediction: NE, 59.7% (by a mean of three.5 factors)

Matchup must-reads: Hill committed to Dolphins amid frustrating seasonPatriots lose C Andrews to surgery, could make RB changeMayo sticking with Brissett as starting QB

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Stephen A.: Tyreek leaving Mahomes could possibly be the best mistake in NFL historical past

Stephen A. Smith argues that Tyreek Hill’s resolution to go away the Chiefs for the Dolphins may find yourself being the largest mistake ever made by an NFL participant.


1 p.m. ET | Fox | ESPN BET: WSH -3 (43.5 O/U)

Browns storyline to observe: The Browns proceed to battle on offense, and now they face the NFL’s hottest offense, so it is crucial for Cleveland’s protection to return to its elite 2023 type for the group to have an opportunity. The Browns have struggled to carry gamers to the bottom, permitting 2.24 yards after contact after rush, the worst mark within the league. The Commanders rank third in speeding yards per recreation (169.3) and sixth in yards after contact per rush (2.11). — Daniel Oyefusi

Commanders storyline to observe: Washington’s protection performed its finest recreation final week against Arizona, holding the Cardinals to 115 whole passing yards because it sacked QB Kyler Murray 4 occasions. The Commanders prevented him from hurting them off schedule, one thing they will need to do towards Cleveland’s Deshaun Watson as effectively. However the Commanders stay dangerous versus the run, permitting 5.3 yards per carry, which ranks thirty first within the NFL. The Browns rank seventeenth speeding the ball at 4.3 yards per carry. — John Keim

Stat to know: Commanders QB Jayden Daniels‘ 4 speeding touchdowns are tied for essentially the most by a quarterback by way of his first 4 video games in NFL historical past. Cam Newton (2011) and Anthony Richardson (2023) are the one quarterbacks with 5 speeding touchdowns by way of 5 video games since 1970.

Daring prediction: Commanders defensive tackles Jonathan Allen and Daron Payne could have large video games, with at the very least 1.5 sacks and 5 mixed tackles between them. With Wyatt Teller (knee) injured, the inside of the Browns’ offensive line is hurting. Christian Wilkins took benefit final week, and Washington’s duo will do the identical. — Walder

Accidents: Browns | Commanders

Fantasy X issue: Watson. He has struggled this season, averaging simply 13.7 fantasy factors per recreation. Even with high receivers Amari Cooper and Jerry Jeudy, he hasn’t thrown for over 200 yards in a single recreation. The Commanders rank sixth in whole yards allowed per recreation and third in factors per recreation. Provided that the Commanders enable the second-most fantasy factors to quarterbacks, this could possibly be a major alternative for Watson to show issues round. See Week 5 rankings. — Moody

Betting nugget: Overs are 8-2 in Cleveland highway video games because the begin of final season. Read more.

Kahler’s decide: Commanders 21, Browns 13
Moody’s decide: Commanders 28, Browns 21
Walder’s decide: Commanders 24, Browns 14
FPI prediction: WSH, 63.2% (by a mean of 5.2 factors)

Matchup must-reads: Chubb returns to practice, says knee feels goodCommanders’ Daniels on success: ‘Still a rookie’Watson downplays sideline spat: ‘Got to execute’Daniels shakes off first INT, keeps Commanders rolling


1 p.m. ET | CBS | ESPN BET: JAX -3 (46.5 O/U)

Colts storyline to observe: In one of many NFL’s extra confounding streaks, the Colts have not gained a highway recreation towards Jacksonville since 2014. In these 9 conferences, together with a 2016 London recreation for which the Jaguars had been designated as the house group, the Colts had been shut out twice and had been outscored by a mean of 16 factors per recreation. How? Turnovers, for one. Jacksonville has a plus-15 margin in these video games. — Stephen Holder

Jaguars storyline to observe: The Jaguars stay the one group that hasn’t pressured a turnover on protection this season (they recovered a muffed punt final week for his or her solely turnover thus far), which makes for an attention-grabbing dilemma towards the Colts. QB Anthony Richardson — who injured his hip final week and was restricted in follow — has thrown a league-high six interceptions, however his working means, arm energy and potential for large performs make him harmful. Backup QB Joe Flacco is not going to run round, however he shredded the Jaguars final season with the Browns (311 yards and three TDs). — Mike DiRocco

Stat to know: The Colts’ previous six video games have been determined by single digits, which is the second-longest lively streak within the NFL (the Chiefs lead with seven).

Daring prediction: Richardson will throw at the very least two interceptions. The Colts is likely to be lacking Jonathan Taylor (ankle), and the Jaguars are good at stopping the run, so Indianapolis may lean on its aerial assault. Richardson could make particular performs, however his accuracy stays a significant concern. He has the bottom completion share over expectation (minus-15%) amongst qualifying quarterbacks this season, per NFL Subsequent Gen Stats. — Walder

Accidents: Colts | Jaguars

Fantasy X issue: Jaguars large receiver Brian Thomas Jr. The rookie had a breakout efficiency in Week 4, with a career-high 9 targets and 21.9 fantasy factors. Thomas has run the third-most routes (108) on the Jaguars, however he has been extremely environment friendly together with his alternatives. This week, he faces a Colts protection that provides up the fourth-most receptions and fifth-most fantasy factors per recreation to large receivers. Thomas is a high-end flex possibility with immense upside. See Week 5 rankings. — Moody

Betting nugget: The Jaguars could possibly be the primary 0-4 or worse group to shut as favorites since 2020. Read more.

Kahler’s decide: Colts 28, Jaguars 24
Moody’s decide: Jaguars 23, Colts 21
Walder’s decide: Jaguars 30, Colts 13
FPI prediction: JAX, 50.7% (by a mean of 0.2 factors)

Matchup must-reads: Should Richardson not run as much?Is the Jaguars’ season salvageable after 0-4 start?


1 p.m. ET | CBS | ESPN BET: BUF -1 (47.5 O/U)

Payments storyline to observe: It might solely be Week 5, however the Payments’ protection is already coping with a wide range of challenges, the newest coming with Von Miller‘s four-game suspension this week. Whereas center linebacker Terrel Bernard (pectoral) has an excellent probability to make it again to the sphere after lacking two video games, Buffalo will seemingly see rookie security Cole Bishop make his first NFL begin — Taylor Rapp is in concussion protocol — whereas rookie Javon Solomon will see extra of a job on the road with Miller out. A tricky job will await within the Texans’ offense with QB C.J. Stroud throwing seven passing touchdowns and 0 interceptions in his previous 5 house video games. — Alaina Getzenberg

Texans storyline to observe: Coach DeMeco Ryans mentioned the Texans are “fired up” for this matchup however mentioned his membership will not lean into the storyline of two AFC contenders. The Payments have the third-highest level differential within the NFL (plus-39), whereas the Texans are twenty fourth (minus-15), displaying the Payments have been extra full by way of 4 weeks. The Texans have three wins, however every victory was secured within the final minute after they performed sloppy all through. — DJ Bien-Aime

Stat to know: If Josh Allen does not throw an interception, it is going to be the longest streak by a Buffalo quarterback to begin a season in franchise historical past.

Daring prediction: Texans large receiver Tank Dell has 85-plus receiving yards and a landing. I am ready for the Dell breakout recreation, and it’s coming. The second-year wideout nonetheless has a powerful 69 open score this season, an indication that his lowered manufacturing is probably going extra a product of elevated goal competitors. — Walder

Accidents: Bills | Texans

play

7:44

Is Stefon Diggs’ matchup with the Payments a revenge recreation?

Dan Orlovsky, Stephen A. Smith and Mina Kimes debate if Stefon Diggs going up towards the Payments is taken into account a revenge recreation.

Fantasy X issue: Texans working again Joe Mixon. Buffalo’s protection is permitting essentially the most fantasy factors per recreation to working backs this season, making it an amazing matchup for Mixon. He has been rehabbing an ankle sprain for a couple of weeks, and there was optimism he may return for Week 4 after training. He was in the end dominated out, however this matchup can be good for Mixon’s return. See Week 5 rankings. — Moody

Betting nugget: Allen is 27-18-2 ATS in his profession on the highway (13-7-1 ATS as highway underdog). Read more.

Kahler’s decide: Texans 27, Payments 21
Moody’s decide: Payments 27, Texans 23
Walder’s decide: Texans 27, Payments 24
FPI prediction: BUF, 56.0% (by a mean of two.2 factors)

Matchup must-reads: How Settlers of Catan has brought the Buffalo Bills nearer … Texans, Stroud treating Bills game as ‘just another week’Diggs blocking out noise, excited to face Bills


4:05 p.m. ET | Fox | ESPN BET: DEN -2.5 (35.5 O/U)

Raiders storyline to observe: With Davante Adams both (A) on his method out via trade and/or (B) out with a hamstring injury, control the continued improvement of younger velocity receivers Tre Tucker and DJ Turner II because the Raiders try and run their successful streak within the collection to 9 straight. Each scored their first respective profession TDs final week with Adams sidelined. And each discovered the tip zone on working performs, a reverse and a jet sweep. “I hope DJ and Tre contact the ball 1,000,000 extra occasions, actually,” mentioned new Raiders WR1 Jakobi Meyers. “That was good to see. I used to be completely happy for them, and so they deserved it.” — Paul Gutierrez

Broncos storyline to observe: The Broncos’ first divisional matchup of the season comes towards a Raiders group they have not overwhelmed since 2019. Denver has to determine its offense in a rush if it needs to keep away from a ninth straight loss to its AFC West foe. It has scored all of 4 touchdowns this season, and rookie quarterback Bo Nix has simply two go completions that gained 30-plus yards. Coach Sean Payton has defended Nix’s progress, however with opponents crowding the quick and intermediate areas — the place Nix has primarily thrown the ball — the Broncos need to push down the sphere with extra consistency. One factor that would affect the Denver go recreation: Raiders edge rusher Maxx Crosby, who has 13.5 sacks over 10 video games towards the Broncos, missed a number of practices this week with a left ankle injury. — Jeff Legwold

Stat to know: The Raiders are looking for back-to-back highway wins for the primary time since Weeks 11-12 in 2022. They gained at Baltimore in Week 2.

Daring prediction: Broncos linebacker Cody Barton will document 12 or extra mixed tackles. Taking over a bigger function following Alex Singleton‘s ACL tear, Barton racked up 10 mixed tackles final week towards the Jets together with a 63% run cease win price — the third highest in Week 4. — Walder

Accidents: Raiders | Broncos

Fantasy X issue: Broncos working again Javonte Williams. The Broncos’ protection has been strong, and with the Raiders lacking Adams, Denver may discover itself taking part in with a lead. The Broncos’ offensive line ranks ninth in run block win price (73.1%), and Williams is coming off a season-high 18 touches in Week 4. The Raiders’ protection additionally provides up the eighth-most fantasy factors to working backs. See Week 5 rankings. — Moody

Betting nugget: The Raiders have coated six straight conferences and 12 of the previous 13 conferences. Read more.

Kahler’s decide: Broncos 20, Raiders 17
Moody’s decide: Broncos 20, Raiders 17
Walder’s decide: Broncos 19, Raiders 16
FPI prediction: DEN, 52.6% (by a mean of 0.6 factors)

Matchup must-reads: Raiders ‘focused on Denver’ amid Adams dramaNewcomers, unsung heroes keying dominant Broncos defenseGround game breathing life into LV offense


4:05 p.m. ET | Fox | ESPN BET: SF -7 (49.5 O/U)

Cardinals storyline to observe: After scoring 88 factors of their first three video games and both successful or coming inside a landing, the Cardinals had been caught within the mud final week. They will strive every thing of their playbook to get again on observe towards the rival 49ers, however that begins with getting rookie large receiver Marvin Harrison Jr. concerned extra within the offense past the primary quarter and ensuring quarterback Kyler Murray runs a couple of time for 3 yards. — Josh Weinfuss

49ers storyline to observe: Many eyes might be on the 2 quarterbacks right here, but when the Niners are to win their fifth straight towards Arizona and keep away from dropping to 0-2 within the division for the primary time since 2021, they will want working again Jordan Mason to once more do some heavy lifting. Mason is second within the NFL in speeding yards (447) and faces a Cardinals run protection that has allowed a league-high eight speeding touchdowns, has the bottom run cease win price within the NFL (26.5%) and is twenty seventh in run protection success price (52.1%). Cardinals again James Conner additionally will get a good matchup because the league’s Twelfth-leading rusher goes towards a Niners protection that is twenty fourth in success price (55.8%) towards the run. — Nick Wagoner

Stat to know: The Cardinals are 3-13 of their previous 16 highway video games, courting again to Week 6 of 2022. They’re tied with the Bears for second-worst highway document over that span.

Daring prediction: The 49ers will rating 40-plus factors. I do know there’s some concern for San Francisco given the 2-2 begin with key accidents, but it surely nonetheless ranks second in EPA per dropback, and Arizona ranks twenty seventh in EPA per dropback allowed. — Walder

Accidents: Cardinals | 49ers

Fantasy X issue: 49ers quarterback Brock Purdy. The 49ers are closely favored over the Cardinals, and the matchup has one of many highest level totals. That is nice information for Purdy. He has accomplished 68.9% of his passes this season, and Arizona permits the fourth-most fantasy factors per recreation to quarterbacks. This places Purdy in a major place to shine. See Week 5 rankings. — Moody

Betting nugget: The Cardinals are 3-12 ATS of their previous 15 video games towards division opponents. Read more.

Kahler’s decide: 49ers 33, Cardinals 24
Moody’s decide: 49ers 34, Cardinals 17
Walder’s decide: 49ers 40, Cardinals 17
FPI prediction: SF, 69.8% (by a mean of seven.9 factors)

Matchup must-reads: Why has WR Harrison’s offensive involvement dropped off after first quarter?Emergence of WR Jennings a good problem for 49ers, Aiyuk49ers’ fears alleviated with Warner (ankle) day-to-day


4:25 p.m. ET | CBS | ESPN BET: GB -3 (48.5 O/U)

Packers storyline to observe: Whereas Packers coach Matt LaFleur has struggled towards his former boss, Kyle Shanahan, going 2-4 towards his 49ers, it has been the alternative for LaFleur towards one other former boss, Rams coach Sean McVay. LaFleur, who was McVay’s offensive coordinator with the Rams in 2017 and labored with McVay in Washington from 2010 to 2013, has by no means misplaced to McVay in 4 head-to-head conferences, together with the playoffs. — Rob Demovsky

Rams storyline to observe: The Rams’ protection is ranked thirty first in DVOA, permitting essentially the most yards per play (6.4), the second-most yards per recreation (385.3) and the second-most factors per recreation (28.8) within the NFL this season, in accordance with ESPN Analysis. It will not get any simpler because the Packers rank third in offensive DVOA and whole yards per recreation (410). — Sarah Barshop

Stat to know: Kyren Williams has had a speeding landing in seven consecutive video games courting again to final season, tied with Johnny Drake in 1939 for the second-longest streak in Rams historical past (Greg Bell, 10 straight from 1988 to 1989).

Daring prediction: Packers quarterback Jordan Love will throw a landing apiece to Jayden Reed, Dontayvion Wicks and Romeo Doubs. I anticipate Like to get again within the groove after a gradual begin in his return in Week 4, and the Rams rank final amongst all groups in defensive EPA per play. — Walder

Accidents: Packers | Rams

Fantasy X issue: Reed. He has constructed robust chemistry with Love. Reed posted 33.1 fantasy factors with Love against the Eagles in Week 1 and had 27.1 factors versus the Vikings. This week, the duo faces a Rams protection that is permitting the ninth-most fantasy factors to large receivers. Given his reference to Love and the favorable matchup, Reed is squarely on the WR1 radar for Week 5. See Week 5 rankings. — Moody

Betting nugget: Rams QB Matthew Stafford is 14-23-1 ATS in his profession as a house underdog (2-2-1 ATS with the Rams). Read more.

Kahler’s decide: Packers 24, Rams 20
Moody’s decide: Packers 34, Rams 27
Walder’s decide: Packers 31, Rams 17
FPI prediction: GB, 56.6% (by a mean of two.5 factors)

Matchup must-reads: Rookie K Narveson knows he’s testing Packers’ patienceCan the 1-3 Rams turn it around before it’s too late?

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0:43

Kyren Williams’ fantasy outlook after Week 4

Try some key fantasy stats from Kyren Williams’ efficiency within the Rams’ highway loss to the Bears.


4:25 p.m. ET | CBS | ESPN BET: SEA -6.5 (43.5 O/U)

Giants storyline to observe: Large receiver Jalin Hyatt has simply three targets and no catches within the first 4 weeks. It is his time to shine with rookie standout wideout Malik Nabers coping with a concussion. Nabers is averaging 13 targets per recreation. That ought to create loads of alternatives for Hyatt, final yr’s third-round decide, even when it will not be simple towards a Seahawks protection that has allowed simply 9 receptions of 20 or extra yards this season. Jordan Raanan

Seahawks storyline to observe: The Seahawks try to bounce again from their worst defensive efficiency of the season. The 42 factors they allowed of their loss to Detroit on Monday night time was greater than double what they’d allowed in any of their first three video games, although it got here with roughly half their protection sidelined with accidents. They’re hoping to get Leonard Williams (ribs), Uchenna Nwosu (knee), Boye Mafe (knee), Julian Love (thigh) and Jerome Baker (hamstring) again this week. — Brady Henderson

Stat to know: The Seahawks are tied for the fourth-most sacks within the NFL with 14. Seattle has recorded at the very least three sacks in every of previous three video games.

Daring prediction: Giants large receiver Darius Slayton could have 5 or extra receptions. If Nabers misses this recreation, these targets are going to need to go someplace, and so they cannot all go to Wan’Dale Robinson. Although Slayton hasn’t gotten a ton of targets, he has been strong with a 62 open rating this yr. — Walder

Accidents: Giants | Seahawks

Fantasy X issue: Seahawks large receiver DK Metcalf. Metcalf has been on fireplace recently, averaging 10.6 targets and 21.5 fantasy factors over his previous three video games. Recognized for working a excessive share of his routes on the surface, Metcalf faces a Giants protection that surrenders the fourth-most fantasy factors to outdoors receivers. Anticipate an enormous recreation for Metcalf towards Giants cornerback Deonte Banks. See Week 5 rankings. — Moody

Betting nugget: All 4 Giants video games have gone beneath the entire this season. Read more.

Kahler’s decide: Seahawks 24, Giants 17
Moody’s decide: Seahawks 27, Giants 14
Walder’s decide: Seahawks 24, Giants 6
FPI prediction: SEA, 65.3% (by a mean of 5.7 factors)

Matchup must-reads: Giants ‘disappointed but not discouraged’ going into Week 5Why Seahawks plan to lean on RB Walker moreSeahawks add veteran lineman Peters to practice squad


8:20 p.m. ET | NBC/Peacock | ESPN BET: PIT -2.5 (44.5 O/U)

Cowboys storyline to observe: The Cowboys might be with out their two finest gamers on protection in Micah Parsons (ankle) and DeMarcus Lawrence (foot), going through the Tenth-best speeding offense. Can they present crucial consistency towards a Steelers offense that averaged 34.5 speeding makes an attempt per recreation regardless of averaging simply 3.7 yards per carry? The Cowboys are twenty seventh in run protection however gave up simply 26 speeding yards final week. With out their two finest edge rushers, the Cowboys must comprise QB Justin Fields as a runner and thrower. — Todd Archer

Steelers storyline to observe: The Steelers’ protection had an uncharacteristic efficiency in Week 4, giving up a season-high 27 factors to the Colts and permitting them to transform 53% of third downs, additionally a season excessive. Whereas the Colts used large performs to place the Steelers on their heels, the Cowboys’ offense hasn’t been practically as explosive. The Cowboys, who might be with out WR2 Brandin Cooks (knee infection), have simply 15 whole passes over 20 yards or carries over 10 yards, marking the second-lowest whole within the league. — Brooke Pryor

Stat to know: The Cowboys are averaging a league-low 75.3 speeding yards per recreation. That is the fourth-worst mark in franchise historical past by way of the primary 4 video games.

Daring prediction: Steelers working again Najee Harris could have 100-plus speeding yards. Even after the Cowboys allowed a league-low 1.2 yards per designed working play to the Giants, they nonetheless are the worst group within the league when it comes to EPA allowed per designed carry. Harris ought to be capable to take benefit. — Walder

Accidents: Cowboys | Steelers

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May Cowboys’ season be over with loss to Steelers?

Dan Orlovsky and Kimberley A. Martin break down why the Cowboys’ season could possibly be over in the event that they lose in Pittsburgh.

Fantasy X issue: Fields. He made historical past towards the Colts, changing into the primary Steelers participant to throw for 300 yards, rush for 50 yards and rating two speeding touchdowns in a single recreation. This week, Fields has an amazing matchup towards a Cowboys protection that provides up the fourth-most fantasy factors to quarterbacks. Dallas additionally ranks fifth in speeding yards allowed to QBs, which bodes effectively for Fields’ dual-threat talents. See Week 5 rankings. — Moody

Betting nugget: The Cowboys are 4-0 ATS on additional relaxation because the begin of final season and 6-0 ATS when together with Week 1 video games. Read more.

Kahler’s decide: Cowboys 21, Steelers 15
Moody’s decide: Steelers 26, Cowboys 19
Walder’s decide: Cowboys 24, Steelers 22
FPI prediction: PIT, 52.6% (by a mean of 0.8 factors)

Matchup must-reads: Cowboys counting on depth with Parsons, Lawrence injuredTomlin leaning toward sticking with hot hand at QB in Fields


8:15 p.m. ET | ESPN | ESPN BET: KC -5 (43.5 O/U)

Saints storyline to observe: Saints tight finish Taysom Hill did not follow on Thursday with separate rib and chest injuries. He has missed seven quarters of play this season, together with a recreation towards the Eagles, because of accidents. The Saints’ run recreation seems to be considerably impacted with Hill out of the lineup. When Hill was on the sphere towards the Falcons, the Saints averaged 6.1 yards per rush in comparison with 2.6 yards per rush with out him within the lineup. — Katherine Terrell

Chiefs storyline to observe: The Saints lead the NFL in scoring at nearly 32 factors per recreation. However the Chiefs have held two different opponents within the high 10 in scoring (Ravens and Bengals) under their season averages. For that matter, the Chiefs held their different two opponents (Falcons and Chargers) under theirs as effectively. — Adam Teicher

Stat to know: Chiefs quarterback Patrick Mahomes‘ 53 QBR is at the moment seventeenth within the NFL. That is the primary season he has posted a QBR beneath 75 in the course of the opening 4 video games.

Daring prediction: The Saints will win. Per week in the past, they narrowly lost to the Falcons regardless of surrendering a muffed punt (returned for a landing) and a pick-six. I consider the New Orleans we noticed the primary couple of weeks is nearer to the actual deal, and the Chiefs are inferior to their document signifies. They rank simply eleventh in EPA per play and are actually with out Rashee Rice (knee). — Walder

Accidents: Saints | Chiefs

Fantasy X issue: Chiefs large receiver Xavier Worthy. He scored 13.7 fantasy factors towards the Chargers, marking his second-best efficiency after 20.8 factors in Week 1. Nonetheless, Worthy had solely 4 targets within the recreation. He ought to see a rise in targets with out Rice, who led the Chiefs with 29 targets. The rookie can be deadly as a runner. Worthy is finest seen as a high-end flex possibility. See Week 5 rankings. — Moody

Betting nugget: The Saints are 7-1 ATS of their previous eight video games as highway underdogs. They’re 16-6 ATS in that function since 2018 and 29-13 ATS since 2014. Read more.

Kahler’s decide: Chiefs 30, Saints 28
Moody’s decide: Chiefs 23, Saints 16
Walder’s decide: Saints 24, Chiefs 20
FPI prediction: KC, 60.6% (by a mean of 4.2 factors)

Matchup must-reads: ‘Sucks to lose a game like that’: Injured Saints look to regroup as Chiefs loomExtent of Rice’s injury still unclear

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